Results 91 to 100 of about 4,841 (226)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Older Adults' Self‐Care and Family Caregiver Contribution in Multiple Chronic Conditions: A Dyadic Qualitative Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To explore how older adult‐family caregiver dyads jointly manage multiple chronic conditions. Specifically, it investigates how dyads (i) prioritise chronic diseases, (ii) make and negotiate decisions related to self‐care and (iii) define and distribute self‐care tasks and caregiver contributions.
Giulia Andrea Baldan, Irene Dello Iacono, Valentina Giurissevich, Davide Ausili, Ercole Vellone, Maddalena De Maria, Maria Matarese   +6 more
wiley   +1 more source

Immune cell infiltration correlates with intestinal permeability, inflammation, and gastrointestinal symptoms in type 1 diabetes

Journal of Diabetes Investigation, EarlyView.
In individuals with type 1 diabetes, immune cell infiltration in the colon mucosa tended to correlate with fecal and systemic markers of intestinal permeability and inflammation, as well as gastrointestinal symptoms. These findings suggest that low‐grade gut immune activation might link the intestinal barrier dysfunction with systemic endotoxin ...
Polina Zalizko, Reinis Isaks, Leonora Pahirko, Aleksejs Fedulovs, Eduards Krustins, Jurijs Nazarovs, Sergejs Dubencovs, Hanne Salmenkari, Markku Lehto, Kaspars Jēkabsons, Una Riekstiņa, Per‐Henrik Groop, Niina Sandholm, Jeļizaveta Sokolovska   +13 more
wiley   +1 more source

Insensibilité congénitale à la douleur

The Pan African Medical Journal, 2014
L'insensibilité congénitale à la douleur (ICD), est une affection rare de transmission autosomique récessive, caractérisée par une absence congénitale de la perception de la douleur.
Kawtar Inani, Fatimazahra Mernissi
doaj   +1 more source

Hereditary sensory and autonomic neuropathy type 2 [PDF]

, 2020
INSERM
openalex   +1 more source

NTRK1-related Hereditary Sensory and Autonomic Neuropathy Type 4: The Role of the Histamine Challenge Test [PDF]

, 2022
Amytice Mirchi, Julie Richer, Maryam Oskoui, Hugh J. McMillan   +3 more
openalex   +1 more source

The Veterans Affairs Neuropathy Scale: A Reliable, Remote Polyneuropathy Exam. [PDF]

, 2019
Introduction: Polyneuropathy (PN) complaints are common, prompting many referrals for neurologic evaluation. To improve access of PN care in distant community clinics, we developed a telemedicine service (patient-clinician interactions using real-time ...
Jamal, Nasheed I, Ong, Michael K, Saliba, Debra, Wilson, Andrew M   +3 more
core  

Myocardial ischemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: therapeutic options [PDF]

, 2020
During the last decades, mortality of acute myocardial infarction has been dramatically improved, however, the incidence of post-infarction heart failure is still increasing.
Bencsik Péter, Ferdinandy Péter, Gömöri Kamilla, Görbe Anikó, Helyes Zsuzsanna, Jancsó Gábor, Szabados Tamara, Sántha Péter   +7 more
core   +1 more source

Persistence of fatigue in the absence of pathophysiological mechanisms in some patients more than 2 years after the original SARS‐CoV‐2 infection

Experimental Physiology, EarlyView.
Abstract Following an acute infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a substantial percentage of patients report the persistence of debilitating symptoms, often grouped in a syndrome termed ‘long COVID’. We sought to identify potential pathophysiological mechanisms responsible for the persistence, in some long COVID ...
Giovanni Baldassarre, Lucrezia Zuccarelli, Thomas Favaretto, Caterina Ursella, Andrea Palomba, Paulo Cesar do Nascimento Salvador, Emanuela Sozio, Ernesto Crisafulli, Massimo Imazio, Carlo Tascini, Bruno Grassi   +10 more
wiley   +1 more source

Uncoupling neurotrophic function from nociception of nerve growth factor: what can be learned from a rare human disease?

Neural Regeneration Research, 2019
Nerve growth factor (NGF) is a powerful trophic factor that provides essential support for the survival and differentiation of sympathetic and sensory neurons during development.
Kijung Sung, Wanlin Yang, Chengbiao Wu
doaj   +1 more source