Results 251 to 258 of about 33,807 (258)

ADMET Evaluation in Drug Discovery. 16. Predicting hERG Blockers by Combining Multiple Pharmacophores and Machine Learning Approaches.

Molecular Pharmaceutics, 2016
Blockade of human ether-à-go-go related gene (hERG) channel by compounds may lead to drug-induced QT prolongation, arrhythmia, and Torsades de Pointes (TdP), and therefore reliable prediction of hERG liability in the early stages of drug design is quite ...
Shuangquan Wang, Huiyong Sun, Hui Liu, Dan Li, Youyong Li, Tingjun Hou   +5 more
semanticscholar   +1 more source

Characterization of a hERG Screen Using the IonWorks HT: Comparison to a hERG Rubidium Efflux Screen

ASSAY and Drug Development Technologies, 2005
The introduction of parallel patch clamp instruments offers the promise of moderate-throughput, high-fidelity voltage clamp for drug screening assays. One such device, the IonWorks HT (Molecular Devices, Sunnyvale, CA), was evaluated and compared to conventional human ethera- go-go-related gene (hERG) patch clamp data and an alternative functional ...
Tony Priestley, Kristal R. Tucker, Steve Sorota, Michael Margulis, Xue Song Zhang   +4 more
openaire   +3 more sources

GraphDeep-hERG: Graph Neural Network PharmacoAnalytics for Assessing hERG-Related Cardiotoxicity

Pharmaceutical Research
The human Ether-a-go-go Related-Gene (hERG) encodes rectifying potassium channels that play a significant role during action potential repolarization of cardiomyocytes. Blockade of the hERG channel by off-target drugs can lead to long QT syndrome, significantly increasing the risk of proarrhythmic cardiotoxicity.
Yankang Jing, Yiyang Zhang, Guangyi Zhao, Terence McGuire, Jack Zhao, Ben Gibbs, Ganqian Hou, Zhiwei Feng, Ying Xue, Xiang-Qun Xie   +9 more
openaire   +2 more sources

Development of Safe Drugs: The hERG Challenge

Medicinal research reviews (Print), 2018
S. Kalyaanamoorthy, K. Barakat
semanticscholar   +1 more source

Facilitation of hERG Current Occurs in Various hERG Channel Blockers

Journal of Molecular and Cellular Cardiology, 2008
Yoshihisa Kurachi, Atsushi Inanobe, Kazuharu Furutani   +2 more
openaire   +2 more sources

hERG potassium channels and cardiac arrhythmia

Nature, 2006
M. Sanguinetti, M. Tristani-Firouzi
semanticscholar   +1 more source

EXPANDING THE SCOPE OF THE hERG BINDING ASSAY: hERG TRAFFICKING AND METABOLITE TESTING

Journal of Pharmacological and Toxicological Methods, 2007
Peter A. Smith, Colleen Doherty, Hong Zang, Suresh K. Balani, Arek Raczynski, Vivek J. Kadambi, Scott Coleman, Carl L. Alden   +7 more
openaire   +2 more sources

hERG: The long and short of it

Heart Rhythm, 2008
openaire   +2 more sources