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AMP-activated protein kinase regulates hERG potassium channel

Pflügers Archiv - European Journal of Physiology, 2013
Besides their role in cardiac repolarization, human ether-a-go-go-related gene potassium (hERG) channels are expressed in several tumor cells including rhabdomyosarcoma cells. The channels foster cell proliferation. Ubiquitously expressed AMP-dependent protein kinase (AMPK) is a serine-/threonine kinase, stimulating energy-generating and inhibiting ...
Almilaji, Ahmad +8 more
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S641 contributes HERG K+ channel inactivation.

Cell biochemistry and biophysics, 2009
The kinetics of voltage-dependent inactivation of the rapidly activating delayed rectifier, IKr, are unique among K+ channels. The human ether-a-gogo-related gene (HERG) encodes the pore-forming subunit of IKr and shares a high degree of homology with ether-a-gogo (EAG) channels that do not inactivate. Within those segments thought to contribute to the
Jin-Song, Bian +3 more
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Insights into hERG channel activators

The human Ether-a-go-go-Related Gene (hERG) potassium channel plays a crucial role in cardiac repolarization. Dysfunction of this channel can lead to severe cardiac arrhythmias, particularly Long QT Syndrome (LQTS), which is associated with an increased risk of torsades de pointes and sudden cardiac death.
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Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole

Structure, 2021
Naruhiko Adachi, Toshio Moriya, Takamitsu Maru +2 more
exaly

HERG-channels

2006
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Facilitation of hERG Current Occurs in Various hERG Channel Blockers