Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression [PDF]
Data in Brief, 2017 The data presented in this article are related to the research article entitled “The effects of deoxyelephantopin on the cardiac delayed rectifier potassium channel current (IKr) and human ether-a-go-go-related gene (hERG) expression” (Y.F.
Yi Fan Teah +5 more
doaj +6 more sources
Structural modeling of the hERG potassium channel and associated drug interactions [PDF]
Frontiers in Pharmacology, 2022 The voltage-gated potassium channel, KV11.1, encoded by the human Ether-à-go-go-Related Gene (hERG), is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential.
Jan Maly +12 more
doaj +4 more sources
Aggregation-Induced Emission: Lighting Up hERG Potassium Channel [PDF]
Frontiers in Chemistry, 2019 Based on the scaffold of astemizole and E-4031, four AIE light-up probes (L1–L4) for Human Ether-a-go-go-Related Gene (hERG) potassium channel were developed herein using AIE fluorogen(TPE).
Xiaomeng Zhang +4 more
doaj +5 more sources
Noncanonical electromechanical coupling paths in cardiac hERG potassium channel [PDF]
Nature Communications, 2023 Potassium channels allow vital organ such as brain, heart, and muscles to function. Here, authors reveal the existence of a noncanonical kinematic chain of residues involving the S4/S1 and S1/S5 subunit interfaces that controls the gating of the hERG ...
Carlos A. Z. Bassetto +4 more
doaj +6 more sources
Ion conduction through the hERG potassium channel. [PDF]
PLoS ONE, 2012 The inward rectifier voltage-gated potassium channel hERG is of primary importance for the regulation of the membrane potential of cardiomyocytes. Unlike most voltage-gated K(+)-channels, hERG shows a low elementary conductance at physiological voltage ...
Luisa Ceccarini +3 more
doaj +6 more sources
In silico Exploration of Interactions Between Potential COVID-19 Antiviral Treatments and the Pore of the hERG Potassium Channel—A Drug Antitarget [PDF]
Frontiers in Cardiovascular Medicine, 2021 Background: In the absence of SARS-CoV-2 specific antiviral treatments, various repurposed pharmaceutical approaches are under investigation for the treatment of COVID-19.
Ehab Al-Moubarak +2 more
doaj +2 more sources
Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue [PDF]
Pharmaceuticals, 2023 hERG (human Ether-à-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (IKr) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-induced form of ...
Matthew V. Helliwell +4 more
doaj +2 more sources
Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7-Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues. [PDF]
Drug Dev ResABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Chenu E +7 more
europepmc +2 more sources
Second-generation antipsychotics – Cardiac ion channel modulation and QT interval disturbances: A review [PDF]
Biomolecules & BiomedicineSecond-generation antipsychotics (SGAs) are frequently prescribed in psychiatry due to their efficacy and improved tolerability compared to first-generation agents.
Orhan Erkan +3 more
doaj +2 more sources
Results in Chemistry, 2021 A full-length three-dimensional structure of the tetrameric potassium ion channel (hERG Kv11.1) including the N- and C-terminal domains was built, with a diameter of 6 Å and 12 Å between the K + selectivity filter and the pore cavity residue Tyr652 of ...
Nataraj Sekhar Pagadala
doaj +1 more source