Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue [PDF]
Pharmaceuticals, 2023 hERG (human Ether-à-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (IKr) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-induced form of ...
Matthew V. Helliwell +4 more
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Structural modeling of the hERG potassium channel and associated drug interactions [PDF]
Frontiers in Pharmacology, 2022 The voltage-gated potassium channel, KV11.1, encoded by the human Ether-à-go-go-Related Gene (hERG), is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential.
Jan Maly +12 more
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In silico Exploration of Interactions Between Potential COVID-19 Antiviral Treatments and the Pore of the hERG Potassium Channel—A Drug Antitarget [PDF]
Frontiers in Cardiovascular Medicine, 2021 Background: In the absence of SARS-CoV-2 specific antiviral treatments, various repurposed pharmaceutical approaches are under investigation for the treatment of COVID-19.
Ehab Al-Moubarak +2 more
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Noncanonical electromechanical coupling paths in cardiac hERG potassium channel [PDF]
Nature Communications, 2023 Potassium channels allow vital organ such as brain, heart, and muscles to function. Here, authors reveal the existence of a noncanonical kinematic chain of residues involving the S4/S1 and S1/S5 subunit interfaces that controls the gating of the hERG ...
Carlos A. Z. Bassetto +4 more
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Aggregation-Induced Emission: Lighting Up hERG Potassium Channel [PDF]
Frontiers in Chemistry, 2019 Based on the scaffold of astemizole and E-4031, four AIE light-up probes (L1–L4) for Human Ether-a-go-go-Related Gene (hERG) potassium channel were developed herein using AIE fluorogen(TPE).
Xiaomeng Zhang +4 more
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Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression [PDF]
Data in Brief, 2017 The data presented in this article are related to the research article entitled “The effects of deoxyelephantopin on the cardiac delayed rectifier potassium channel current (IKr) and human ether-a-go-go-related gene (hERG) expression” (Y.F.
Yi Fan Teah +5 more
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Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging [PDF]
ACS Medicinal Chemistry Letters, 2016 Zhao Ma, Lupei Du, Minyong Li
exaly +2 more sources
Results in Chemistry, 2021 A full-length three-dimensional structure of the tetrameric potassium ion channel (hERG Kv11.1) including the N- and C-terminal domains was built, with a diameter of 6 Å and 12 Å between the K + selectivity filter and the pore cavity residue Tyr652 of ...
Nataraj Sekhar Pagadala
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hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. [PDF]
PLoS ONE, 2013 The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear.The hERG potassium channel blockage by a new 36-residue scorpion ...
Jian Ma +5 more
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Frontiers in Pharmacology, 2021 The rapidly activating delayed rectifier K+ current generated by the cardiac hERG potassium channel encoded by KCNH2 is the most important reserve current for cardiac repolarization.
Zheng Zequn, Lian Jiangfang
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