Frontiers in Pharmacology, 2022 Background: Old drugs for new indications in the novel coronavirus disease of 2019 (COVID-19) pandemic have raised concerns regarding cardiotoxicity, especially the development of drug-induced QT prolongation.
Zequn Zheng +11 more
doaj +1 more source
The Human Ether-a-go-go-related Gene (hERG) Potassium Channel Represents an Unusual Target for Protease-mediated Damage. [PDF]
J Biol Chem, 2016 Lamothe SM +4 more
europepmc +2 more sources
Сardioprotective agents with biaromatic structure. Part 5. Potassium Kv1.5-channels blockers
Фармакокинетика и Фармакодинамика, 2023 The Kv1.5 potassium channel provides an ultra-rapid delayed rectifier potassium current, IKur, that acts selectively in human atrial cells. This makes selective Kv1.5 blockade a promising approach to control atrial arrhythmias without the adverse ...
G. V. Mokrov
doaj +1 more source
The antipsychotic drug chlorpromazine inhibits HERG potassium channels [PDF]
British Journal of Pharmacology, 2003 Acquired long QT syndrome (aLQTS) is caused by prolongation of the cardiac action potential because of blockade of cardiac ion channels and delayed repolarization of the heart. Patients with aLQTS carry an increased risk for torsade de pointes arrhythmias and sudden cardiac death. Several antipsychotic drugs may cause aLQTS.
Dierk, Thomas +6 more
openaire +2 more sources
Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]
, 2016 Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia +17 more
core +1 more source
Toward a Consensus Model of the hERG Potassium Channel [PDF]
ChemMedChem, 2010 AbstractMalfunction of hERG potassium channels, due to inherited mutations or inhibition by drugs, can cause long QT syndrome, which can lead to life‐threatening arrhythmias. A three‐dimensional structure of hERG is a prerequisite to understand the molecular basis of hERG malfunction.
Stary, A. +8 more
openaire +6 more sources
Chemistry, 2022 The human ether-a-go-go-related gene (hERG) potassium channel is a well-known contributor to drug-induced cardiotoxicity and therefore is an extremely important target when performing safety assessments of drug candidates.
Himanshu Goel +2 more
doaj +1 more source
Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell [PDF]
, 1999 The potassium M current was originally identified in sympathetic ganglion cells, and analogous currents have been reported in some central neurons and also in some neural cell lines.
Abogadie, FC +7 more
core +1 more source
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block. [PDF]
PLoS ONE, 2016 Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (ECG) by blocking the hERG potassium channel and also block inward currents (late sodium or L-type calcium) are not associated with torsade de pointes (e.g. ranolazine
Jose Vicente +6 more
doaj +1 more source
Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp [PDF]
, 2015 BACKGROUND: An in vitro electrophysiological assay system, which can assess compound effects and thus show cardiotoxicity including arrhythmia risks of test drugs, is an essential method in the field of drug development and toxicology.
Atsushi Ohtsuki +3 more
core +7 more sources