Results 21 to 30 of about 1,529,868 (197)

Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. [PDF]

PLoS ONE, 2017
The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (IKr) and contributes to phase III cardiac action potential repolarization.
Dahai Yu, Lin Lv, Li Fang, Bo Zhang, Junnan Wang, Ge Zhan, Lei Zhao, Xin Zhao, Baoxin Li   +8 more
doaj   +1 more source

An Insight into the Potassium Currents of hERG and Their Simulation

Molecules, 2023
By assuming that a stepwise outward movement of the four S4 segments of the hERG potassium channel determines a concomitant progressive increase in the flow of the permeant potassium ions, the inward and outward potassium currents can be simulated by ...
Rolando Guidelli
doaj   +1 more source

Voltage-Dependent Gating of hERG Potassium Channels [PDF]

Frontiers in Pharmacology, 2012
The mechanisms by which voltage-gated channels sense changes in membrane voltage and energetically couple this with opening of the ion conducting pore has been the source of significant interest. In voltage-gated potassium (Kv) channels, much of our knowledge in this area comes from Shaker-type channels, for which voltage-dependent gating is quite ...
Cheng, Yen May, Claydon, Tom W.
openaire   +3 more sources

Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants

Molecular Therapy: Nucleic Acids, 2023
Disease-causing premature termination codons (PTCs) individually disrupt the functional expression of hundreds of genes and represent a pernicious clinical challenge.
Viggo G. Blomquist, Jacqueline Niu, Papiya Choudhury, Ahmad Al Saneh, Henry M. Colecraft, Christopher A. Ahern   +5 more
doaj   +1 more source

Toward a Consensus Model of the hERG Potassium Channel [PDF]

ChemMedChem, 2010
AbstractMalfunction of hERG potassium channels, due to inherited mutations or inhibition by drugs, can cause long QT syndrome, which can lead to life‐threatening arrhythmias. A three‐dimensional structure of hERG is a prerequisite to understand the molecular basis of hERG malfunction.
Stary, A., Wacker, S.J., Boukharta, L., Zachariae, U.G., Karimi-Nejad, Y., Aqvist, J., Vriend, G., Vriend, G., de Groot, B.L.   +8 more
openaire   +6 more sources

New synthetic cannabinoids and the potential for cardiac arrhythmia risk

Journal of Molecular and Cellular Cardiology Plus, 2023
Synthetic cannabinoid receptor agonists (SCRAs) have been associated with QT interval prolongation. Limited preclinical information on SCRA effects on cardiac electrogenesis results from the rapid emergence of new compounds and restricted research ...
Jules C. Hancox, Caroline S. Copeland, Stephen C. Harmer, Graeme Henderson   +3 more
doaj   +1 more source

Na+ Permeation and Block of hERG Potassium Channels [PDF]

The Journal of General Physiology, 2006
The inactivation gating of hERG channels is important for the channel function and drug–channel interaction. Whereas hERG channels are highly selective for K+, we have found that inactivated hERG channels allow Na+ to permeate in the absence of K+. This provides a new way to directly monitor and investigate hERG inactivation.
Gang, Hongying, Zhang, Shetuan
openaire   +2 more sources

hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes

, 2015
hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de ...
D. Melgari (7639616), G. André Ng (7595840), C. E. Dempsey (2535865), John Mitcheson (7684796), J. C. Hancox (7639622), Kieran E. Brack (7605593)   +5 more
core   +5 more sources

Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

BMC Molecular and Cell Biology, 2021
Background Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1.
Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura, Ichio Shimada, Masanori Osawa   +14 more
doaj   +1 more source

Quercetin is a foe in the heart by targeting the hERG potassium channel. [PDF]

Iran J Basic Med Sci
Quercetin is a plant flavonoid known for its pharmacological activities, such as antioxidant, anti-inflammatory, and anti-cancer properties. However, there is limited information available regarding its potential toxicities. A previous study showed that quercetin can inhibit human ether-a-go-related gene (hERG, also named KCNH2) currents, which may ...
Lu Z, Li S, Wei R, Li W, Huang Y, Yang T, Yan M.   +6 more
europepmc   +4 more sources