Results 21 to 30 of about 12,393 (207)

Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants

Molecular Therapy: Nucleic Acids, 2023
Disease-causing premature termination codons (PTCs) individually disrupt the functional expression of hundreds of genes and represent a pernicious clinical challenge.
Viggo G. Blomquist, Jacqueline Niu, Papiya Choudhury, Ahmad Al Saneh, Henry M. Colecraft, Christopher A. Ahern   +5 more
doaj   +1 more source

Antiarrhythmic drug carvedilol inhibits HERG potassium channels [PDF]

Cardiovascular Research, 2001
The aryloxypropanolamine carvedilol is a multiple action cardiovascular drug with blocking effects on alpha-receptors, beta-receptors, Ca(2+)-channels, Na(+)-channels and various native cardiac K(+) channels, thereby prolonging the cardiac action potential. In a number of clinical trials with patients suffering from congestive heart failure, carvedilol
C A, Karle, V A, Kreye, D, Thomas, K, Röckl, S, Kathöfer, W, Zhang, J, Kiehn   +6 more
openaire   +2 more sources

New synthetic cannabinoids and the potential for cardiac arrhythmia risk

Journal of Molecular and Cellular Cardiology Plus, 2023
Synthetic cannabinoid receptor agonists (SCRAs) have been associated with QT interval prolongation. Limited preclinical information on SCRA effects on cardiac electrogenesis results from the rapid emergence of new compounds and restricted research ...
Jules C. Hancox, Caroline S. Copeland, Stephen C. Harmer, Graeme Henderson   +3 more
doaj   +1 more source

Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging. [PDF]

ACS Med Chem Lett, 2016
Wang B, Liu Z, Ma Z, Li M, Du L.
europepmc   +2 more sources

Na+ Permeation and Block of hERG Potassium Channels [PDF]

The Journal of General Physiology, 2006
The inactivation gating of hERG channels is important for the channel function and drug–channel interaction. Whereas hERG channels are highly selective for K+, we have found that inactivated hERG channels allow Na+ to permeate in the absence of K+. This provides a new way to directly monitor and investigate hERG inactivation.
Gang, Hongying, Zhang, Shetuan
openaire   +2 more sources

Mechanisms of hERG Potassium Channel Enhancers [PDF]

Biophysical Journal, 2011
Mutations in the human Ether-a-go-go related gene (hERG) potassium channel and hERG channel blockers offer tools for studying structural, biophysical and functional properties of the channel. However, the current understanding of how the hERG channel opens and closes is still incomplete. Here, we used alternative chemical tools, hERG channel enhancers,
Lin, Chia-Wei, Cao, Xueying, Penland, Robert, Urban, Laszlo, Erdemli, Gul   +4 more
openaire   +1 more source

Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

BMC Molecular and Cell Biology, 2021
Background Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1.
Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura, Ichio Shimada, Masanori Osawa   +14 more
doaj   +1 more source

Phα1β interaction with the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG channel [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: This study examines the impact of Phα1β, a spider peptide derived from the venom of Phoneutria nigriventer, on the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG potassium channel.
João B. Calixto, Adara Aurea dos Santos, Juliano Ferreira, Alessandra Hubner Souza, Célio José de Castro Junior, Marcus Vinicius Gomez   +5 more
doaj   +1 more source

Chaperone Rer1 involves in transport of hERG potassium channel protein in cell line HEK293T [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the role of Rer1 in hERG potassium channel protein transport,and to study the medicine Baf A1 that may restore abnormal hERG transport.
CHEN Bang-sheng, YU Xiao-ling, MAO Fei-yan, LIAN Jiang-fang, YU Xu-yun
doaj  

Lead optimisation of dehydroemetine for repositioned use in malaria [PDF]

, 2020
Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi ...
Abubaker, M, Bryce, RA, Burusco, KK, Fernández-Álvaro, E, Gutnov, A, Matthews, H, Nirmalan, NJ, Panwar, P, Wilkinson, JA   +8 more
core   +3 more sources