Results 11 to 20 of about 12,393 (207)
A minK-HERG complex regulates the cardiac potassium current I(Kr). [PDF]
Nature, 1997 MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.
Fishman, GI +7 more
core +2 more sources
Mechanism of C-type inactivation in the hERG potassium channel. [PDF]
Sci Adv, 2021 C-type inactivation in hERG is associated with an asymmetrical constricted-like conformation of the selectivity filter.
Li J, Shen R, Reddy B, Perozo E, Roux B.
europepmc +5 more sources
hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. [PDF]
PLoS ONE, 2013 The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear.The hERG potassium channel blockage by a new 36-residue scorpion ...
Jian Ma +5 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The rapidly activating delayed rectifier K+ current generated by the cardiac hERG potassium channel encoded by KCNH2 is the most important reserve current for cardiac repolarization.
Zheng Zequn, Lian Jiangfang
doaj +1 more source
Structural modeling of hERG channel–drug interactions using Rosetta
Frontiers in Pharmacology, 2023 The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target.
Aiyana M. Emigh Cortez +17 more
doaj +1 more source
Фармакокинетика и Фармакодинамика, 2023 The hERG subtype potassium channel (Kv11.1) is one of the most important and one of the most studied biological targets for the creation of cardioprotective agents.
G. V. Mokrov
doaj +1 more source
Voltage-Dependent Gating of hERG Potassium Channels [PDF]
Frontiers in Pharmacology, 2012 The mechanisms by which voltage-gated channels sense changes in membrane voltage and energetically couple this with opening of the ion conducting pore has been the source of significant interest. In voltage-gated potassium (Kv) channels, much of our knowledge in this area comes from Shaker-type channels, for which voltage-dependent gating is quite ...
Cheng, Yen May, Claydon, Tom W.
openaire +3 more sources
Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. [PDF]
PLoS ONE, 2017 The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (IKr) and contributes to phase III cardiac action potential repolarization.
Dahai Yu +8 more
doaj +1 more source
An Insight into the Potassium Currents of hERG and Their Simulation
Molecules, 2023 By assuming that a stepwise outward movement of the four S4 segments of the hERG potassium channel determines a concomitant progressive increase in the flow of the permeant potassium ions, the inward and outward potassium currents can be simulated by ...
Rolando Guidelli
doaj +1 more source
Alprenolol Inhibits Herg Potassium Channels [PDF]
Biophysical Journal, 2010 The action of alprenolol, a non-selective beta blocker as well as 5-HT receptor antagonist, on the cloned cardiac human ether-a-go-go-related gene (HERG) channels was investigated using the whole-cell patch-clamp technique. Alprenolol reduced HERG whole-cell currents in a reversible concentration-dependent manner, with an IC50 value and a Hill ...
Lee, Seung Ho +2 more
openaire +1 more source