Ion conduction through the hERG potassium channel. [PDF]
PLoS ONE, 2012 The inward rectifier voltage-gated potassium channel hERG is of primary importance for the regulation of the membrane potential of cardiomyocytes. Unlike most voltage-gated K(+)-channels, hERG shows a low elementary conductance at physiological voltage ...
Luisa Ceccarini +3 more
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hERG potassium channel inhibition by ivabradine requires channel gating [PDF]
Journal of Molecular and Cellular Cardiology, 2015 hERG potassium channel inhibition by ivabradine requires channel ...
D. Melgari (7639616) +23 more
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Mechanism of C-type inactivation in the hERG potassium channel. [PDF]
Sci Adv, 2021 The fast C-type inactivation displayed by the voltage-activated potassium channel hERG plays a critical role in the repolarization of cardiac cells, and malfunction caused by nonspecific binding of drugs or naturally occurring missense mutations ...
Li J, Shen R, Reddy B, Perozo E, Roux B.
europepmc +6 more sources
Structural modeling of hERG channel–drug interactions using Rosetta [PDF]
Frontiers in Pharmacology, 2023 The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target.
Aiyana M. Emigh Cortez +17 more
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Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulators [PDF]
Фармакокинетика и Фармакодинамика, 2023 The hERG subtype potassium channel (Kv11.1) is one of the most important and one of the most studied biological targets for the creation of cardioprotective agents.
G. V. Mokrov
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Chaperone Rer1 involves in transport of hERG potassium channel protein in cell line HEK293T [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate the role of Rer1 in hERG potassium channel protein transport,and to study the medicine Baf A1 that may restore abnormal hERG transport.
CHEN Bang-sheng, YU Xiao-ling, MAO Fei-yan, LIAN Jiang-fang, YU Xu-yun
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Early Steps in C-Type Inactivation of the hERG Potassium Channel. [PDF]
J Chem Inf Model, 2023 [Image: see text] Fast C-type inactivation confers distinctive functional properties to the hERG potassium channel, and its association to inherited and acquired cardiac arrythmias makes the study of the inactivation mechanism of hERG at the atomic ...
Pettini F, Domene C, Furini S.
europepmc +3 more sources
Mechanisms underlying probucol-induced hERG-channel deficiency
Drug Design, Development and Therapy, 2015 Yuan-Qi Shi,1,* Cai-Chuan Yan,1,* Xiao Zhang,1 Meng Yan,1 Li-Rong Liu,1 Huai-Ze Geng,1 Lin Lv,1 Bao-Xin Li1,21Department of Pharmacology, Harbin Medical University, 2State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin, Heilongjiang ...
Shi YQ +7 more
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Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency
Drug Design, Development and Therapy, 2015 Meng Yan,1 Kaiping Zhang,1 Yanhui Shi,1 Lifang Feng,1 Lin Lv,1 Baoxin Li1,2 1Department of Pharmacology, Harbin Medical University, 2State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin, Heilongjiang, People’s Republic of China ...
Yan M +5 more
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The Eag potassium channel as a new prognostic marker in ovarian cancer [PDF]
Diagnostic Pathology, 2010 Background Ovarian cancer is the second most common cancer of the female genital tract in the United Kingdom (UK), accounting for 6% of female deaths due to cancer.
Schalkwyk Gerhard V +6 more
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