Results 1 to 10 of about 1,218,415 (224)

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

Drug Design, Development and Therapy, 2015
Meng Yan,1 Kaiping Zhang,1 Yanhui Shi,1 Lifang Feng,1 Lin Lv,1 Baoxin Li1,2 1Department of Pharmacology, Harbin Medical University, 2State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin, Heilongjiang, People’s Republic of China ...
Yan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX   +5 more
doaj   +1 more source

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome

Heliyon, 2019
Congenital short QT syndrome (SQTS) is a repolarization disorder characterized by abbreviated QT intervals, atrial and ventricular arrhythmias and a risk of sudden death. This study characterized a missense mutation (I560T) in the S5 domain of the hERG K+
Andrew Butler, Yihong Zhang, A. Graham Stuart, Christopher E. Dempsey, Jules C. Hancox   +4 more
doaj   +1 more source

Phα1β interaction with the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG channel [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: This study examines the impact of Phα1β, a spider peptide derived from the venom of Phoneutria nigriventer, on the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG potassium channel.
João B. Calixto, Adara Aurea dos Santos, Juliano Ferreira, Alessandra Hubner Souza, Célio José de Castro Junior, Marcus Vinicius Gomez   +5 more
doaj   +1 more source

A Heterozygous Missense hERG Mutation Associated with Early Repolarization Syndrome

Cellular Physiology and Biochemistry, 2018
Background/Aims: Early repolarization syndrome (ERS) has been recently recognized as early repolarization pattern with idiopathic ventricular fibrillation. However, the genetic background of ERS has not been fully understood.
Yun-Jiu Cheng, Hao Yao, Cheng-Cheng Ji, Xu-Miao Chen, Jun Fan, Li-Juan Liu, Su-Hua Wu   +6 more
doaj   +1 more source

ERG1A K+ channel increases intracellular calcium concentration through modulation of calsequestrin1 in C2C12 myotubes

Scientific Reports
The ERG1A K+ channel modulates the protein degradation that contributes to skeletal muscle atrophy by increasing intracellular calcium concentration ([Ca2+]i) and enhancing calpain activity, but the mechanism by which the channel regulates the [Ca2+]i is
Gregory H. Hockerman, Evan Pratt, Shalini Guha, Emily LaVigne, Clayton Whitmore, Omar Khader, Natalie McClure, Sandra Zampieri, Jennifer Koran, W.-H. Wang, Amber L. Pond   +10 more
doaj   +1 more source

Procaine, a State-Dependent Blocker, Inhibits HERG Channels by Helix Residue Y652 and F656 in the S6 Transmembrane Domain

Journal of Pharmacological Sciences, 2013
The article evaluated the inhibitory action of procaine on wild-type and mutated HERG potassium channel current (IHERG) to determine whether mutations in the S6 region are important for the inhibition of IHERG by procaine.
Na Wang, Ji Hua Ma, Pei Hua Zhang
doaj   +1 more source

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

PLoS ONE, 2019
The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines.
Damodara Reddy Vaddi, Lin Piao, Shakil A Khan, Ning Wang, Nanduri R Prabhakar, Jayasri Nanduri   +5 more
doaj   +1 more source

Derivation of Highly Predictive 3D-QSAR Models for hERG Channel Blockers Based on the Quantum Artificial Neural Network Algorithm. [PDF]

Pharmaceuticals (Basel), 2023
Kim T, Chung KC, Park H.
europepmc   +1 more source

Hysteretic hERG channel gating current recorded at physiological temperature. [PDF]

Sci Rep, 2022
Jones DK.
europepmc   +1 more source

An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG

BMC Biology
Background Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity.
Zhipei Liu, Feng Wang, Hui Yuan, Fuyun Tian, Chuanyan Yang, Fei Hu, Yiyao Liu, Meiqin Tang, Meixuan Ping, Chunlan Kang, Ting Luo, Guimei Yang, Mei Hu, Zhaobing Gao, Ping Li   +14 more
doaj   +1 more source