Results 41 to 50 of about 17,722 (214)

New synthetic cannabinoids and the potential for cardiac arrhythmia risk

Journal of Molecular and Cellular Cardiology Plus, 2023
Synthetic cannabinoid receptor agonists (SCRAs) have been associated with QT interval prolongation. Limited preclinical information on SCRA effects on cardiac electrogenesis results from the rapid emergence of new compounds and restricted research ...
Jules C. Hancox, Caroline S. Copeland, Stephen C. Harmer, Graeme Henderson   +3 more
doaj   +1 more source

Early LQT2 Nonsense Mutation Generates N-Terminally Truncated hERG Channels with Altered Gating Properties by the Reinitiation of Translation

, 2012
Mutations in the human ether-a-go-go-related gene (hERG) result in long QT syndrome type 2 (LQT2). The hERG gene encodes a K+ channel that contributes to the repolarization of the cardiac action potential.
Gong, Qiuming, Packer, Jonathan D., Stump, Matthew R., Zhou, Zhengfeng   +3 more
core   +1 more source

hERG potassium channel inhibition by ivabradine requires channel gating

Journal of Molecular and Cellular Cardiology, 2015
The file associated with this record is under a 12-month embargo from publication in accordance with the publisher's self-archiving policy, available at http://www.elsevier.com/about/company-information/policies/sharing. The full text may be available in the publisher links provided above.
Melgari, Dario, Brack, Kieran E, Zhang, Yihong, El Harchi, Aziza, Mitcheson, John S, Dempsey, Christopher E, Ng, G André, Hancox, Jules C   +7 more
openaire   +3 more sources

Molecular medicine of microRNAs: structure, function and implications for diabetes [PDF]

, 2008
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences.
Duncan, Erica Hennessy, Lorraine O'Driscoll, Offield, Schleicher, Zhou   +5 more
core   +1 more source

Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp [PDF]

, 2015
BACKGROUND: An in vitro electrophysiological assay system, which can assess compound effects and thus show cardiotoxicity including arrhythmia risks of test drugs, is an essential method in the field of drug development and toxicology.
Atsushi, Ohtsuki, Haraguchi, Yuji, Shimizu, Tatsuya, Takayuki, Oka   +3 more
core   +6 more sources

Early identification of hERG liability in drug discovery programs by automated patch clamp

Frontiers in Pharmacology, 2014
Blockade of the cardiac ion channel coded by hERG can lead to cardiac arrhythmia, which has become a major concern in drug discovery and development.
Timm eDanker, Clemens eMöller
doaj   +1 more source

Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1

Frontiers in Pharmacology, 2021
Aims: The short QT syndrome type 1 (SQT1) is linked to hERG channel mutations (e.g., N588K). Drug effects on hERG channel gating kinetics in SQT1-cells have not been investigated.Methods: This study used hiPSC-CMs of a healthy donor and a SQT1-patient ...
Mengying Huang, Zhenxing Liao, Zhenxing Liao, Xin Li, Xin Li, Zhen Yang, Zhen Yang, Xuehui Fan, Xuehui Fan, Yingrui Li, Zhihan Zhao, Siegfried Lang, Siegfried Lang, Lukas Cyganek, Lukas Cyganek, Xiaobo Zhou, Xiaobo Zhou, Xiaobo Zhou, Ibrahim Akin, Ibrahim Akin, Martin Borggrefe, Martin Borggrefe, Ibrahim El-Battrawy, Ibrahim El-Battrawy   +23 more
doaj   +1 more source

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations. [PDF]

, 2019
Drug-induced block of the cardiac rapid delayed rectifying potassium current (I Kr), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome.
Chen, I-Shan, Furutani, Kazuharu, Handa, Kenichiro, Kurachi, Yoshihisa, Sack, Jon T, Tsumoto, Kunichika, Yamakawa, Yuko   +6 more
core   +1 more source

Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator [PDF]

, 2018
We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we identified a hydroxycoumarin-related compound, ostruthin, as an activator of this channel ...
Joseph, Ancy, Okada, Masayoshi, Thanh, Le Tat, Thuy, Tran Thi Thu   +3 more
core   +2 more sources

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source