Results 61 to 70 of about 17,722 (214)
, 2017 Blockage of some ion channels and in particular, the hERG cardiac potassium channel delays cardiac repolarization and can induce arrhythmia. In some cases it leads to a potentially life-threatening arrhythmia known as Torsade de Pointes (TdP).
Buzatu, Dan +3 more
core +1 more source
, 2008 The slides are from a presentation given by Professor Ravi Iyengar from Mount Sinai School of Medicine at the Drug Forum Meeting #9 that took place in Washington, DC on February 20-21, 2008.
Ravi Iyengar
core +2 more sources
Addiction, EarlyView.Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley +1 more source
High-Throughput Chemical Screening and Structure-Based Models to Predict hERG Inhibition
Biology, 2022 Chemical inhibition of the human ether-a -go-go-related gene (hERG) potassium channel leads to a prolonged QT interval that can contribute to severe cardiotoxicity.
Shagun Krishna +5 more
doaj +1 more source
Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs). [PDF]
, 2001 Voltage-gated potassium channels provide tightly Controlled, ion-specific pathways across membranes and are key to the normal function of nerves muscles. They arise from the assembly of four pore-forming proteins called alpha-subunits.
Abbott, GW, Goldstein, SA
core
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi +29 more
wiley +1 more source
Na+ Permeation and Block of hERG Potassium Channels [PDF]
The Journal of General Physiology, 2006 The inactivation gating of hERG channels is important for the channel function and drug–channel interaction. Whereas hERG channels are highly selective for K+, we have found that inactivated hERG channels allow Na+ to permeate in the absence of K+. This provides a new way to directly monitor and investigate hERG inactivation.
Gang, Hongying, Zhang, Shetuan
openaire +2 more sources
Stereoselective Block of hERG Channel by Bupivacaine Scrutinized at Molecular Level
CHIMIA, 2010 In the heart, the hERG voltage-gated potassium channel mediates the IKr current, which is crucial for the duration of cardiac action potential.
Liliana Sintra Grilo +2 more
doaj +1 more source
An Update on the Structure of hERG
Frontiers in Pharmacology, 2020 The human voltage-sensitive K+ channel hERG plays a fundamental role in cardiac action potential repolarization, effectively controlling the QT interval of the electrocardiogram.
Andrew Butler +4 more
doaj +1 more source
A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). [PDF]
, 1998 MinK and MinK-related peptide I (MiRPI) are integral membrane peptides with a single transmembrane span. These peptides are active only when co-assembled with pore-forming K+ channel subunits and yet their role in normal ion channel behaviour is ...
Abbott, GW, Goldstein, SA
core