Results 31 to 40 of about 1,218,415 (224)

Assembly of Cell-Free Synthesized Ion Channel Molecules in Artificial Lipid Bilayer Observed by Atomic Force Microscopy

Membranes, 2023
Artificial lipid bilayer systems, such as vesicles, black membranes, and supported lipid bilayers (SLBs), are valuable platforms for studying ion channels at the molecular level.
Melvin Wei Shern Goh, Yuzuru Tozawa, Ryugo Tero   +2 more
doaj   +1 more source

Investigation of the Influence of hERG 1b on hERG Channel Pharmacology [PDF]

Biophysical Journal, 2013
hERG channels mediating the rapid delayed rectifier K+ current (IKr) are important for normal ventricular repolarization. In native cardiac tissues, hERG 1a subunit co-assembles with a subunit encoded by an alternate transcript, “ERG1b” which has a shorter N-terminus (1) and influences current kinetics (2).
El Harchi, Aziza, Melgari, Dario, Hancox, Jules C.   +2 more
openaire   +1 more source

HERG-like K+ Channels in Microglia [PDF]

The Journal of General Physiology, 1998
A voltage-gated K+ conductance resembling that of the human ether-à-go-go-related gene product (HERG) was studied using whole-cell voltage-clamp recording, and found to be the predominant conductance at hyperpolarized potentials in a cell line (MLS-9) derived from primary cultures of rat microglia.
W, Zhou, F S, Cayabyab, P S, Pennefather, L C, Schlichter, T E, DeCoursey   +4 more
openaire   +2 more sources

Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulators

Фармакокинетика и Фармакодинамика, 2023
The hERG subtype potassium channel (Kv11.1) is one of the most important and one of the most studied biological targets for the creation of cardioprotective agents.
G. V. Mokrov
doaj   +1 more source

Towards a complete structure of the hERG channel [PDF]

Journal of Cheminformatics, 2013
A lot of attention has been drawn to the voltage gated potassium channel Kv11.1 during the last decades. In the past, both, ligand and structure based methods intended to predict if a small molecule could cause fatal heart arrhythmias, “torsades de pointe” and sudden death. However, despite the wide interest for hERG, still no experimental 3D structure
Peter Schmidtke, Ciantar Marine, Isabelle Theret, Pierre Ducrot   +3 more
openaire   +2 more sources

Computational prediction of hERG blockers using homology modelling, molecular docking and QuaSAR studies

Results in Chemistry, 2021
A full-length three-dimensional structure of the tetrameric potassium ion channel (hERG Kv11.1) including the N- and C-terminal domains was built, with a diameter of 6 Å and 12 Å between the K + selectivity filter and the pore cavity residue Tyr652 of ...
Nataraj Sekhar Pagadala
doaj   +1 more source

Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome [PDF]

, 2011
The short QT syndrome (SQTS) is a genetically heterogeneous condition characterized by abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death.
Hancox Jules C., McPate, Mark J., Mark J McPate, Hancox, Jules C., Witchel, HJ, Witchel Harry J., Witchel, Harry J., Ismail Adeniran, Zhang, H., Hancox, JC, McPate, MJW, Henggui Zhang (74233), Ismail Adeniran (192479), Adeniran, I., Adeniran, Ismail, Zhang Henggui, Adeniran Ismail, Zhang, Henggui, Henggui Zhang, Jules C Hancox, Harry Witchel (4462174), Jules C Hancox (16149998), McPate Mark J., Mark J McPate (16150001), Harry J Witchel   +24 more
core   +2 more sources

Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether‐à‐go‐go–Related Gene and Cav1.2

Frontiers in Pharmacology, 2022
Background: Old drugs for new indications in the novel coronavirus disease of 2019 (COVID-19) pandemic have raised concerns regarding cardiotoxicity, especially the development of drug-induced QT prolongation.
Zequn Zheng, Zequn Zheng, Zequn Zheng, Dihui Cai, Dihui Cai, Yin Fu, Yin Fu, Ying Wang, Yongfei Song, Yongfei Song, Jiangfang Lian, Jiangfang Lian   +11 more
doaj   +1 more source

Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells

Journal of Arrhythmia, 2017
Background: Pilsicainide, classified as a relatively selective Na+ channel blocker, also has an inhibitory action on the rapidly-activating delayed-rectifier K+ current (IKr) through human ether-a-go-go-related gene (hERG) channels.
Takeshi Onohara, MD, Ichiro Hisatome, MD, Yasutaka Kurata, MD, Peili Li, MD, Tomomi Notsu, PhD, Kumi Morikawa, PhD, Naoyuki Otani, MD, Akio Yoshida, MD, Kazuhiko Iitsuka, MD, Masaru Kato, MD, Junichiro Miake, MD, Haruaki Ninomiya, MD, Katsumi Higaki, PhD, Yasuaki Shirayoshi, PhD, Takashi Nishihara, BE, Toshiyuki Itoh, PhD, Yoshinobu Nakamura, MD, Motonobu Nishimura, MD   +17 more
doaj   +1 more source

Voltage-Dependent Gating of hERG Potassium Channels [PDF]

Frontiers in Pharmacology, 2012
The mechanisms by which voltage-gated channels sense changes in membrane voltage and energetically couple this with opening of the ion conducting pore has been the source of significant interest. In voltage-gated potassium (Kv) channels, much of our knowledge in this area comes from Shaker-type channels, for which voltage-dependent gating is quite ...
Cheng, Yen May, Claydon, Tom W.
openaire   +3 more sources