Results 31 to 40 of about 17,722 (214)
Alprenolol Inhibits Herg Potassium Channels [PDF]
Biophysical Journal, 2010 The action of alprenolol, a non-selective beta blocker as well as 5-HT receptor antagonist, on the cloned cardiac human ether-a-go-go-related gene (HERG) channels was investigated using the whole-cell patch-clamp technique. Alprenolol reduced HERG whole-cell currents in a reversible concentration-dependent manner, with an IC50 value and a Hill ...
Lee, Seung Ho +2 more
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Klotho sensitivity of the hERG channel
FEBS Letters, 2013 Klotho, a hormone and enzyme, is a powerful regulator of ageing and life span. Klotho deficiency leads to cardiac arrythmia and sudden cardiac death. We thus explored whether klotho modifies cardiac K+‐channel hERG. Current was determined utilizing dual electrode voltage clamp and hERG protein abundance utilizing immunohistochemistry and ...
Munoz, Carlos +8 more
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Antiarrhythmic drug carvedilol inhibits HERG potassium channels [PDF]
Cardiovascular Research, 2001 The aryloxypropanolamine carvedilol is a multiple action cardiovascular drug with blocking effects on alpha-receptors, beta-receptors, Ca(2+)-channels, Na(+)-channels and various native cardiac K(+) channels, thereby prolonging the cardiac action potential. In a number of clinical trials with patients suffering from congestive heart failure, carvedilol
C A, Karle +6 more
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In vitro chronic effects on hERG channel caused by the marine biotoxin Yessotoxin.
Frontiers in Marine Science, 2014 INTRODUCTION Marine algal blooms caused by the overgrowth of marine phytoplankton have increased in frequency and severity in the last years; supposing a worldwide public health problem.
Sara Fernández Ferreiro
doaj +1 more source
Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell [PDF]
, 1999 The potassium M current was originally identified in sympathetic ganglion cells, and analogous currents have been reported in some central neurons and also in some neural cell lines.
Abogadie, FC +7 more
core +1 more source
Frontiers in Cardiovascular Medicine, 2021 Background: In the absence of SARS-CoV-2 specific antiviral treatments, various repurposed pharmaceutical approaches are under investigation for the treatment of COVID-19.
Ehab Al-Moubarak +2 more
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Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]
, 2000 Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
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Journal of Pharmacological Sciences, 2019 The human ether-a-go-go-related gene (hERG) encodes the K+ channel that carries the rapid component of the delayed rectifier current in the human heart. Reduction of hERG activity induced by gene mutations or pharmacological inhibition is responsible for
Xiuming Dong +6 more
doaj +1 more source
Multiple mechanisms underlie reduced potassium conductance in the p.T1019PfsX38 variant of hERG
Physiological Reports, 2022 Long QT syndrome type II (LQT2) is caused by loss‐of‐function mutations in the hERG K+ channel, leading to increased incidence of cardiac arrest and sudden death.
Majid K. Al Salmani +3 more
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Diabetes mellitus attenuates the repolarization reserve in mammalian heart [PDF]
, 2007 Objective: In diabetes mellitus several cardiac electrophysiological parameters are known to be affected. In rodent experimental diabetes models changes in these parameters were reported, but no such data are available in other mammalian species ...
Biliczki, Péter +12 more
core +1 more source