Results 11 to 20 of about 17,722 (214)
PIKfyve Sensitivity of hERG Channels [PDF]
Cellular Physiology and Biochemistry, 2013 Background/Aims: Human ether-a-go-go (hERG) channels contribute to cardiac repolarization and participate in the regulation of tumor cell proliferation.
Tatsiana Pakladok +4 more
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State dependent dissociation of HERG channel inhibitors [PDF]
British Journal of Pharmacology, 2007 Background and purpose:Inhibition of HERG channels prolongs the ventricular action potential and the QT interval with the risk of torsade de pointes arrhythmias and sudden cardiac death. Many drugs induce greater inhibition of HERG channels when the cell membrane is depolarized frequently.
Stork, D. +6 more
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Stimulation of HERG channel activity by β-catenin. [PDF]
PLoS ONE, 2012 The multifunctional protein ß-catenin governs as transcription factor the expression of a wide variety of genes relevant for cell proliferation and cell survival.
Carlos Munoz +7 more
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Mechanisms underlying probucol-induced hERG-channel deficiency
Drug Design, Development and Therapy, 2015 Yuan-Qi Shi,1,* Cai-Chuan Yan,1,* Xiao Zhang,1 Meng Yan,1 Li-Rong Liu,1 Huai-Ze Geng,1 Lin Lv,1 Bao-Xin Li1,21Department of Pharmacology, Harbin Medical University, 2State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin, Heilongjiang ...
Shi YQ +7 more
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HERG-like K+ Channels in Microglia [PDF]
The Journal of General Physiology, 1998 A voltage-gated K+ conductance resembling that of the human ether-à-go-go-related gene product (HERG) was studied using whole-cell voltage-clamp recording, and found to be the predominant conductance at hyperpolarized potentials in a cell line (MLS-9) derived from primary cultures of rat microglia.
W, Zhou +4 more
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hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. [PDF]
PLoS ONE, 2013 The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear.The hERG potassium channel blockage by a new 36-residue scorpion ...
Jian Ma +5 more
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Assessing hERG Channel Inhibition Using PatchXpress [PDF]
Clinics in Laboratory Medicine, 2005 PatchXpress, an automated 16-channel parallel patch clamp system, was used to determine inhibition of human ether-a-go-go related gene (hERG) potassium channels by known blockers. A monoclonal cell line stably expressing hERG potassium channels was generated in CHO-KI cells.
Justin Q, Ly +2 more
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Membranes, 2023 Artificial lipid bilayer systems, such as vesicles, black membranes, and supported lipid bilayers (SLBs), are valuable platforms for studying ion channels at the molecular level.
Melvin Wei Shern Goh +2 more
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Results in Chemistry, 2021 A full-length three-dimensional structure of the tetrameric potassium ion channel (hERG Kv11.1) including the N- and C-terminal domains was built, with a diameter of 6 Å and 12 Å between the K + selectivity filter and the pore cavity residue Tyr652 of ...
Nataraj Sekhar Pagadala
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hERG channel function: beyond long QT [PDF]
Acta Pharmacologica Sinica, 2013 To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes.
Babcock, Joseph J, Li, Min
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