Results 191 to 200 of about 12,393 (207)

Altered gating of HERG potassium channels by cobalt and lanthanum

Pflügers Archiv, 2000
Activation of the rapid, delayed rectifier K current (IKr) is important for normal repolarization of cardiac action potentials, especially in mammalian ventricular muscle. The study of this current has been greatly aided by the discovery that the human ether-a-go-go-related gene (HERG) encodes the pore-forming alpha subunits of these channels.
J A, Sanchez-Chapula, M C, Sanguinetti
openaire   +2 more sources

Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen

Naunyn-Schmiedeberg's Archives of Pharmacology, 2003
Tamoxifen is a nonsteroidal antiestrogen that is commonly used in the treatment of breast cancer. Although antiestrogenic drugs are generally believed not to cause acquired long QT syndrome (LQTS), concerns have been raised by recent reports of QT interval prolongation associated with tamoxifen treatment.
Dierk, Thomas, Bernd, Gut, Syrus, Karsai, Anna-Britt, Wimmer, Kezhong, Wu, Gunnar, Wendt-Nordahl, Wei, Zhang, Sven, Kathöfer, Wolfgang, Schoels, Hugo A, Katus, Johann, Kiehn, Christoph A, Karle   +11 more
openaire   +2 more sources

Automated Patch-Clamp Methods for the hERG Cardiac Potassium Channel

2017
The human Ether-a-go-go Related Gene (hERG) product has been identified as a central ion channel underlying both familial forms of elongated QT interval on the electrocardiogram and drug-induced elongation of the same QT segment. Indeed, reduced function of this potassium channel involved in the repolarization of the cardiac action potential can ...
Sylvie, Houtmann, Brigitte, Schombert, Camille, Sanson, Michel, Partiseti, G Andrees, Bohme   +4 more
openaire   +2 more sources

hERG Potassium Channels in Drug Discovery and Development

2011
Potassium (K+) channels play a central role in the electrical activity of excitable cells. Although there are variety of potassium channels, scientists have developed immense interest in human ether-a-go-go-related gene (hERG) potassium channels due to their involvement in life-threatening cardiac arrhythmia.
Jitendra N. Singh, Shyam S. Sharma
openaire   +1 more source

In silico screening on the herg potassium channel

2011
Während des Arzneistoffentwicklungsprozesses scheitern fast 35% der Arzneistoffe wegen schlechter Absorption, Verteilung, Metabolismus, Ausscheidung und Toxizität (ADMET). Ein wichtiger Bestandteil dieses Scheiterns ist die Interaktion mit Anti-Target Proteinen wie Cytochrom P450, P-glycoprotein und dem hERG Kaliumkanal.
openaire   +1 more source

Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment

Medicinal Research Reviews, 2022
Žan Toplak, Steve Peigneur, Tihomir Tomasic   +2 more
exaly  

The inward rectification mechanism of the HERG cardiac potassium channel

Nature, 1996
Gary Yellen
exaly  

Cryo-EM Structure of the Open Human Ether-à-go-go -Related K + Channel hERG

Cell, 2017
Weiwei Wang, Roderick MacKinnon
exaly  

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia

Cell, 1999
Geoffrey W Abbott, Federico Sesti
exaly  

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Cell, 1995
Michael C Sanguinetti
exaly