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Nutritional Factors and Arrhythmic Risk in Long QT Syndrome: A Narrative Review of Mechanistic and Clinical Evidence. [PDF]

Adv Nutr
Mazzanti A, Floriano M, Kukavica D, Trancuccio A, Priori SG.   +4 more
europepmc   +1 more source

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hERG potassium channels and cardiac arrhythmia

Nature, 2006
hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes individuals to life-threatening arrhythmias. Arrhythmia can also be induced by a blockage of hERG channels by a surprisingly diverse group of drugs.
Michael C, Sanguinetti, Martin, Tristani-Firouzi   +1 more
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The hERG potassium channel as a therapeutic target

Expert Opinion on Therapeutic Targets, 2007
The hERG (human ether-à-go-go-related gene) potassium channel has elicited intense scientific interest due to its counter-intuitive kinetics and its association with arrhythmia and sudden death. hERG blockade is involved in both antiarrhythmic pharmacotherapy and the pathogenesis of familial and acquired long QT syndrome (LQTS). Short QT syndrome (SQTS)
Harry J Witchel
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Escitalopram block of hERG potassium channels

Naunyn-Schmiedeberg's Archives of Pharmacology, 2013
Escitalopram, a selective serotonin reuptake inhibitor, is the pharmacologically active S-enantiomer of the racemic mixture of RS-citalopram and is widely used in the treatment of depression. The effects of escitalopram and citalopram on the human ether-a-go-go-related gene (hERG) channels expressed in human embryonic kidney cells were investigated ...
Yun Ju, Chae, Ji Hyun, Jeon, Hong Joon, Lee, In-Beom, Kim, Jin-Sung, Choi, Ki-Wug, Sung, Sang June, Hahn   +6 more
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Curcumin inhibits hERG potassium channels in vitro

Toxicology Letters, 2012
Curcumin is reported to exert antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anti-tumor activities. The human ether-a-go-go related gene (hERG) encodes the rapid component of the delayed rectifier K⁺ currents. Inhibition of hERG K⁺ channels leads to cardiac repolarization prolongation, which contributes to either the anti ...
Chao-Wei, Hu, Yue, Sheng, Qin, Zhang, Hui-Bin, Liu, Xin, Xie, Wen-Chao, Ma, Rong, Huo, De-Li, Dong   +7 more
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The Phenothiazine Drugs Inhibit hERG Potassium Channels

Drug and Chemical Toxicology, 2005
Cardiovascular adverse effects from phenothiazine drugs are common. The most serious consequences of treatment, arrhythmias and sudden death, are probably rare and most likely to be caused primarily by blockade of cardiac potassium channels such as the human ether-a-go-go-related gene (hERG) channel, which plays a central role in arrhythmogenesis. This
Ki-Suk, Kim, Eun-Joo, Kim
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Effects of donepezil on hERG potassium channels

Brain Research, 2015
Donepezil is a potent, selective inhibitor of acetylcholinesterase, which is used for the treatment of Alzheimer's disease. Whole-cell patch-clamp technique and Western blot analyses were used to study the effects of donepezil on the human ether-a-go-go-related gene (hERG) channel.
Yun Ju, Chae, Hong Joon, Lee, Ji Hyun, Jeon, In-Beom, Kim, Jin-Sung, Choi, Ki-Wug, Sung, Sang June, Hahn   +6 more
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Aconitine blocks HERG and Kv1.5 potassium channels

Journal of Ethnopharmacology, 2010
Aconitum has been widely used to treat various diseases in China for a long time. However, improper use of this drug results in severe intoxication. Aconitine (ACO), a diterpenoid alkaloid from aconitum, mainly contributes to cardio-toxic effects of aconitum and has also been commonly known to induce arrhythmias in animal models.
Yifu, Li, Danna, Tu, Hua, Xiao, Yimei, Du, Anruo, Zou, Yuhua, Liao, Shaohong, Dong   +6 more
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Predictive models for hERG potassium channel blockers

Bioorganic & Medicinal Chemistry Letters, 2005
We report here a general method for the prediction of hERG potassium channel blockers using computational models generated from correlation analyses of a large dataset and pharmacophore-based GRIND descriptors. These 3D-QSAR models are compared favorably with other traditional and chemometric based HQSAR methods.
CIANCHETTA, GIOVANNI, Li Y., Kang J., Rampe D., FRAVOLINI, Arnaldo, CRUCIANI, Gabriele, Vaz R. J.   +6 more
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Current pharmacogenomic studies on hERG potassium channels

Trends in Molecular Medicine, 2013
Genetic polymorphisms in human ether-a-go-go-related gene (hERG) potassium channels are associated with many complex diseases and sensitivity to channel-related drugs. Genotypes may underlie different sensitivities to the same drug, and different drugs selectively repair the functional deficits caused by individual mutations.
Fa-Zhong, He, Howard L, McLeod, Wei, Zhang   +2 more
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