Results 171 to 180 of about 1,529,868 (197)

Phenytoin and phenobarbital inhibit human HERG potassium channels

Epilepsy Research, 2003
Drugs that inhibit the cardiac rapid delayed rectifier potassium ion current (IKr) channel can be proarrhythmic and their clinical use has been associated with sudden unexpected death (SUD). Since SUD is about 20 times more common among people with epilepsy than in the general population, and some data indicate that drug treatment may contribute, we ...
Bengt R, Danielsson, Kate, Lansdell, Leslie, Patmore, Torbjörn, Tomson   +3 more
openaire   +2 more sources

Modulation of HERG Potassium Channels by Extracellular Magnesium and Quinidine

Journal of Cardiovascular Pharmacology, 1999
Torsades de pointes is a polymorphic ventricular arrhythmia resulting from congenital or drug-induced (acquired) QT prolongation. Pharmacologic suppression of repolarizing potassium currents is one mechanism causing the acquired long QT (LQT) syndrome. Recent studies have linked mutations in a gene encoding a potassium channel subunit (HERG) to the LQT
S S, Po, D W, Wang, I C, Yang, J P, Johnson, L, Nie, P B, Bennett   +5 more
openaire   +2 more sources

The regulation of the cardiac potassium channel (HERG) by caveolin-1

Biochemistry and Cell Biology, 2008
Protein–protein interaction plays a key role in the regulation of biological processes. The human potassium (HERG) channel is encoded by the ether-à-go-go-related gene (herg), and its activity may be regulated by association with other cellular proteins.
Jijin, Lin, Shuguang, Lin, Patrick C, Choy, Xiuzhang, Shen, Chunyu, Deng, Sujuan, Kuang, Jun, Wu, Wencan, Xu   +7 more
openaire   +2 more sources

Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen

Naunyn-Schmiedeberg's Archives of Pharmacology, 2003
Tamoxifen is a nonsteroidal antiestrogen that is commonly used in the treatment of breast cancer. Although antiestrogenic drugs are generally believed not to cause acquired long QT syndrome (LQTS), concerns have been raised by recent reports of QT interval prolongation associated with tamoxifen treatment.
Dierk Thomas, Sven Kathöfer, Johann Kiehn   +2 more
exaly   +3 more sources

Modulation of HERG potassium channel properties by external pH

Pfl�gers Archiv European Journal of Physiology, 1999
We expressed the human eag-related gene (HERG), known to encode for the cardiac potassium channel IKr, in Chinese hamster ovary (CHO) cells. This study investigated effects of external pH (pHo) on HERG current properties using the whole-cell patch-clamp technique.
J, Bérubé, M, Chahine, P, Daleau
openaire   +2 more sources

Inhibition of cloned hERG potassium channels by risperidone and paliperidone

Naunyn-Schmiedeberg's Archives of Pharmacology, 2017
Risperidone and one of its active metabolites, paliperidone, are widely used for the treatment of schizophrenia. We used a patch-clamp study to investigate the effects of paliperidone on hERG potassium channels expressed in HEK cells. Western blot analyses were used to study the effects of risperidone and paliperidone on hERG and hERG 3.1 isoform ...
Hong Joon Lee, Jin-Sung Choi, Bok Hee Choi, Sang June Hahn   +3 more
openaire   +2 more sources

Inhibition of cardiac HERG potassium channels by antidepressant maprotiline

European Journal of Pharmacology, 2006
Many drugs block delayed rectifier K+ channels and prolong the cardiac action potential duration. Here we investigate the molecular mechanisms of voltage-dependent block of human ether-a-go-go-related gene (HERG) K+ channels expressed in cells HEK-293 and Xenopus oocytes by maprotiline.
Tania, Ferrer-Villada, Ricardo A, Navarro-Polanco, Aldo A, Rodríguez-Menchaca, Dora E, Benavides-Haro, José A, Sánchez-Chapula   +4 more
openaire   +2 more sources

The inward rectification mechanism of the HERG cardiac potassium channel

Nature, 1996
A human genetic defect associated with 'long Q-T syndrome', an abnormality of cardiac rhythm involving the repolarization of the action potential, was recently found to lie in the HERG gene, which codes for a potassium channel. The HERG K+ channel is unusual in that it seems to have the architectural plan of the depolarization-activated K+ channel ...
P L, Smith, T, Baukrowitz, G, Yellen
openaire   +2 more sources

Altered gating of HERG potassium channels by cobalt and lanthanum

Pflügers Archiv, 2000
Activation of the rapid, delayed rectifier K current (IKr) is important for normal repolarization of cardiac action potentials, especially in mammalian ventricular muscle. The study of this current has been greatly aided by the discovery that the human ether-a-go-go-related gene (HERG) encodes the pore-forming alpha subunits of these channels.
J A, Sanchez-Chapula, M C, Sanguinetti
openaire   +2 more sources

Role of intracellular domains in the function of the herg potassium channel

European Biophysics Journal, 2009
The functional role of the large intracellular regions (which include the cyclic nucleotide binding domain, cNBD, and the Per-Arnt-Sim domain, PAS) in the herg channel is not well understood. We have studied possible interactions of the cNBD with other parts of the channel protein using lysine mutations to disrupt such interactions.
Moza, Al-Owais, Kate, Bracey, Dennis, Wray   +2 more
openaire   +2 more sources