Results 151 to 160 of about 12,393 (207)

Personalized in vitro models reveal functional impact of a <i>KCNH2</i> mutation and enable drug screening in LQTS2. [PDF]

Heart Rhythm O2
Zheng B, Zhu Y, Sun M, Cheng H, Zhang S, Cai C, Gu K, An Y, Ding X, Zhang F, Cui C, Chen M.   +11 more
europepmc   +1 more source

Ether-a-go-go related gene-1a potassium channel abundance varies within specific skeletal muscle fiber type [PDF]

, 2019
Anderson, Luke B., Cobb, Brittan, Khader, Omar, Latour, Chase D., Massey, Bryce H., Pond, Amber L.   +5 more
core   +1 more source

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide. [PDF]

J Mol Cell Cardiol, 2015
Melgari D, Zhang Y, El Harchi A, Dempsey CE, Hancox JC.   +4 more
europepmc   +1 more source

KCNH2-L693P Causes Long QT Syndrome Type 2 Through hERG Channel Dysfunction: Functional Validation of a Variant of Uncertain Significance. [PDF]

Mol Genet Genomic Med
Zheng XF, Chen Q, Lu XT, Dai HL, Guang XF.   +4 more
europepmc   +1 more source

SPARC: a structural pathogenicity algorithm for risk classification of hERG variants. [PDF]

Europace
Chatelain FC, de Oliveira BR, Grataloup G, Robert N, Alameh M, Thollet A, Montnach J, Feliciangeli S, Rio A, Bibault F, Bichet D, Bignucolo O, Extramiana F, Majumder R, Schott JJ, Probst V, Denjoy I, Lesage F, Loussouarn G, De Waard M.   +19 more
europepmc   +1 more source

Amiodarone irrecoverably impairs the function of human ether-a-go-go-related gene potassium channels. [PDF]

Mol Pharmacol
Gelman I, Li W, Guo J, Bogart-Cherry R, Tomei N, Sharma N, Pan A, Yang T, Baranchuk A, El-Diasty M, Zhang S.   +10 more
europepmc   +1 more source

Sudden death-associated KCNH2 variants exert opposing effects on a nuclear subdomain of the cardiac potassium channel hERG1. [PDF]

J Biol Chem
Sanchez-Conde FG, Goodrich MR, Stack OM, Goldberg LNR, Ruzycki PK, Jain A, Jimenez-Vazquez EN, Jones DK.   +7 more
europepmc   +1 more source

Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine. [PDF]

Pharmacol Res Perspect, 2015
Gualdani R, Tadini-Buoninsegni F, Roselli M, Defrenza I, Contino M, Colabufo NA, Lentini G.   +6 more
europepmc   +1 more source

The molecular basis of KCNH1-related epileptic encephalopathy and the challenge of developing targeted therapeutics. [PDF]

Brain
Sundman AK, Jin S, Vadlamudi L, King GF.
europepmc   +1 more source

hERG Channel Blockade and Antagonistic Interactions of Three Steroidal Alkaloids from <i>Fritillaria</i> Species. [PDF]

Molecules
Lu H, Hao T, Zhang Z, Jiang C, Xu J, Stalin A, Zhao W.   +6 more
europepmc   +1 more source