Results 151 to 160 of about 1,529,868 (197)

Quantitative analysis of trafficking defects induced by heterozygous expression of hERG voltage sensor domain variants. [PDF]

Channels (Austin)
Zhang Y, Carr J, Hancox JC, Harmer SC, Dempsey CE.   +4 more
europepmc   +1 more source

A designer pore-blocking peptide reveals an electrostatic complementation mechanism for the inhibition-resistant Kv1.5 channel. [PDF]

Sci Adv
Zhao R, Nayak M, Shen R, Dai H, Hua P, Perozo E, Goldstein SAN.   +6 more
europepmc   +1 more source

Research progress on the relationship between long QT syndrome (LQTS) and epilepsy: A review. [PDF]

Medicine (Baltimore)
Li Q, Meng LB.
europepmc   +1 more source

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hERG potassium channels and cardiac arrhythmia

Nature, 2006
hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes individuals to life-threatening arrhythmias. Arrhythmia can also be induced by a blockage of hERG channels by a surprisingly diverse group of drugs.
Michael C Sanguinetti
exaly   +3 more sources

Current pharmacogenomic studies on hERG potassium channels

Trends in Molecular Medicine, 2013
Genetic polymorphisms in human ether-a-go-go-related gene (hERG) potassium channels are associated with many complex diseases and sensitivity to channel-related drugs. Genotypes may underlie different sensitivities to the same drug, and different drugs selectively repair the functional deficits caused by individual mutations.
Howard L McLeod, Fa-Zhong He
exaly   +3 more sources

The hERG potassium channel as a therapeutic target

Expert Opinion on Therapeutic Targets, 2007
The hERG (human ether-à-go-go-related gene) potassium channel has elicited intense scientific interest due to its counter-intuitive kinetics and its association with arrhythmia and sudden death. hERG blockade is involved in both antiarrhythmic pharmacotherapy and the pathogenesis of familial and acquired long QT syndrome (LQTS). Short QT syndrome (SQTS)
Harry J Witchel
exaly   +3 more sources

Effects of donepezil on hERG potassium channels

Brain Research, 2015
Donepezil is a potent, selective inhibitor of acetylcholinesterase, which is used for the treatment of Alzheimer's disease. Whole-cell patch-clamp technique and Western blot analyses were used to study the effects of donepezil on the human ether-a-go-go-related gene (hERG) channel.
Yun Ju, Chae, Hong Joon, Lee, Ji Hyun, Jeon, In-Beom, Kim, Jin-Sung, Choi, Ki-Wug, Sung, Sang June, Hahn   +6 more
openaire   +2 more sources