Results 131 to 140 of about 12,393 (207)

Caracterização de um domínio do C-terminal de um canal de potássio [PDF]

, 2010
Mestrado em Métodos BiomolecularesDomínios que ligam nucleotideos cíclicos (CNBD) regulam muitas vias de sinalização em células procarióticas e eucarióticas.
Carvalho, Maria João Marques de
core   +1 more source

ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling [PDF]

, 2019
Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In the heart, KCNQ1 associates with KCNE1 subunits to form
Cui, Jianmin, Gao, Yuan, Hou, Panpan, Shi, Jingyi, White, Kelli McFarland   +4 more
core   +1 more source

The mutation L69P in the PAS domain of the hERG potassium channel results in LQTS by trafficking deficiency. [PDF]

Channels (Austin), 2020
Jenewein T, Kanner SA, Bauer D, Hertel B, Colecraft HM, Moroni A, Thiel G, Kauferstein S.   +7 more
europepmc   +1 more source

Gene Therapy in Cardiac Arrhythmias [PDF]

, 2006
Gene therapy has progressed from a dream to a bedside reality in quite a few human diseases. From its first application in adenosine deaminase deficiency, through the years, its application has evolved to vascular angiogenesis and cardiac arrhythmias.
Francis, Johnson, Praveen, S.V, Venugopal, K   +2 more
core  

Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide. [PDF]

Cell Mol Life Sci
Zhang Y, El Harchi A, James AF, Oiki S, Dempsey CE, Hancox JC.   +5 more
europepmc   +2 more sources

Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations

Journal of Biomedical Science
Background Mutations in the HERG potassium channel are a major cause of long QT syndrome type 2 (LQT2), which can lead to sudden cardiac death. The HERG channel plays a critical role in the repolarization of the myocardial action potential, and loss-of ...
Amit Kumawat, Elisa Tavazzani, Giovanni Lentini, Alessandro Trancuccio, Deni Kukavica, Amanda Oldani, Marco Denegri, Silvia G. Priori, Carlo Camilloni   +8 more
doaj   +1 more source

A novel near-infrared fluorescent hERG potassium channel probe for glioblastoma therapy and imaging. [PDF]

Chem Sci
Liu Z, Liu L, Ban T, Wang X, Li R, Zhang X, Wang Y, Li X, Zhang W, Li P, Tang B.   +10 more
europepmc   +1 more source

Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel. [PDF]

Medchemcomm, 2019
Zhang X, Liu T, Wang B, Gao Y, Liu P, Li M, Du L.   +6 more
europepmc   +1 more source

Classification of drug-induced hERG potassium-channel block from electrocardiographic T-wave features using artificial neural networks. [PDF]

Ann Noninvasive Electrocardiol, 2019
Morettini M, Peroni C, Sbrollini A, Marcantoni I, Burattini L.   +4 more
europepmc   +1 more source

Do all voltage-gated potassium channels use MiRPs? [PDF]

, 2001
Abbott, GW, Goldstein, SA, Sesti, F
core