Cardiac Potassium Channels: Physiological Insights for Targeted Therapy. [PDF]
, 2017 The development of novel drugs specifically directed at the ion channels underlying particular features of cardiac action potential (AP) initiation, recovery, and refractoriness would contribute to an optimized approach to antiarrhythmic therapy that ...
A. John Camm +14 more
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Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action
Drug Design, Development and Therapy, 2015 Nadine Vonderlin,1 Fathima Fischer,1 Edgar Zitron,1,2 Claudia Seyler,1 Daniel Scherer,1 Dierk Thomas,1,2 Hugo A Katus,1,2 Eberhard P Scholz1 1Department of Internal Medicine III, University Hospital Heidelberg, 2German Centre for Cardiovascular ...
Vonderlin N +7 more
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Endocytic Regulation of Voltage-Dependent Potassium Channels in the Heart
Journal of Pharmacological Sciences, 2012 Understanding the regulation of cardiac ion channels is critical for the prevention of arrhythmia caused by abnormal excitability. Ion channels can be regulated by a change in function (qualitative) and a change in number (quantitative).
Kuniaki Ishii, Ikuo Norota, Yutaro Obara
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Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency
Drug Design, Development and Therapy, 2015 Meng Yan,1 Kaiping Zhang,1 Yanhui Shi,1 Lifang Feng,1 Lin Lv,1 Baoxin Li1,2 1Department of Pharmacology, Harbin Medical University, 2State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin, Heilongjiang, People’s Republic of China ...
Yan M +5 more
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The molecular determinants of R-roscovitine block of hERG channels.
PLoS ONE, 2019 Human ether-à-go-go-related gene (Kv11.1, or hERG) is a potassium channel that conducts the delayed rectifier potassium current (IKr) during the repolarization phase of cardiac action potentials. hERG channels have a larger pore than other K+channels and
Bryan Cernuda +7 more
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Ginkgo biloba Extract and Ginkgolide Antiarrhythmic Potential by Targeting hERG and ICa-L Channel
Journal of Pharmacological Sciences, 2013 We investigated the effects of Ginkgo biloba extract (GBE) and ginkgolide (GLD) on human ether-a-go-go-related gene (hERG)-encoded K+ channels and its underlying mechanisms in the hERG-HEK293 cell line by determining GBE- and GLD-induced changes in ...
Xin Zhao +8 more
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Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. [PDF]
, 2002 KCNE genes encode single transmembrane-domain subunits, the MinK-related peptides (MiRPs), which assemble with pore-forming alpha subunits to establish the attributes of potassium channels in vivo.
Abbott, Geoffrey W, Goldstein, Steve AN
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ω-3 and ω-6 polyunsaturated fatty acids block HERG channels [PDF]
, 2005 11 pages, 7 figures.Dietary polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, which have been attributed to their availability to modulate Na(+), Ca(2+), and several K(+) channels.
Arias, Cristina +4 more
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The Eag potassium channel as a new prognostic marker in ovarian cancer
Diagnostic Pathology, 2010 Background Ovarian cancer is the second most common cancer of the female genital tract in the United Kingdom (UK), accounting for 6% of female deaths due to cancer.
Schalkwyk Gerhard V +6 more
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Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits. [PDF]
, 2014 KCNE1 (E1) β-subunits assemble with KCNQ1 (Q1) voltage-gated K(+) channel α-subunits to form IKslow (IKs) channels in the heart and ear. The number of E1 subunits in IKs channels has been an issue of ongoing debate.
Dai, Hui +3 more
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