Results 111 to 120 of about 1,529,868 (197)

Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules

, 2011
Human ether-a-go-go related gene (hERG) potassium (K(+)) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG conductance or surface expression may cause congenital long QT syndrome (LQTS).
Gao ZB(高召兵), Li M(李密), Liu LQ(刘连庆), Zhou, Ping-zheng, Babcock, Joseph   +4 more
core  

Activation Gating of hERG Potassium Channels [PDF]

Journal of Biological Chemistry, 2007
Rachael M. Hardman, Phillip J. Stansfeld, Sarah Dalibalta, Michael J. Sutcliffe, John S. Mitcheson   +4 more
openaire   +1 more source

The mutation L69P in the PAS domain of the hERG potassium channel results in LQTS by trafficking deficiency. [PDF]

Channels (Austin), 2020
Jenewein T, Kanner SA, Bauer D, Hertel B, Colecraft HM, Moroni A, Thiel G, Kauferstein S.   +7 more
europepmc   +1 more source

Stereoselective Blockage of Quinidine and Quinine in the hERG Channel and the Effect of Their Rescue Potency on Drug-Induced hERG Trafficking Defect

, 2016
Diastereoisomers of quinidine and quinine are used to treat arrhythmia and malaria, respectively. It has been reported that both drugs block the hERG (human ether-a-go-go-related gene) potassium channel which is essential for myocardium repolarization ...
Yanhui Shi, Pan Fan, Meng Yan, Lifang Feng, Junnan Wang, Baoxin Li, Ge Zhan   +6 more
core   +1 more source

Modeling the hERG potassium channel and its interactions with drugs

, 2007
The human ether-à-go-go-related gene (HERG) was isolated in 1994, and shown to encode a six trans-membrane protein that assembles in a tetrameric complex to form the hERG potassium channel.
RECANATINI, MAURIZIO
core   +1 more source

Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide. [PDF]

Cell Mol Life Sci
Zhang Y, El Harchi A, James AF, Oiki S, Dempsey CE, Hancox JC.   +5 more
europepmc   +2 more sources

Susceptibility of the hERG Potassium Channel to Proteases and its Clinical Implications [PDF]

, 2018
Cardiovascular diseases are the leading cause of death worldwide. Cardiac ischemia accounts for approximately 50% of all cardiovascular-related deaths.
Lamothe, Shawn
core  

Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations

Journal of Biomedical Science
Background Mutations in the HERG potassium channel are a major cause of long QT syndrome type 2 (LQT2), which can lead to sudden cardiac death. The HERG channel plays a critical role in the repolarization of the myocardial action potential, and loss-of ...
Amit Kumawat, Elisa Tavazzani, Giovanni Lentini, Alessandro Trancuccio, Deni Kukavica, Amanda Oldani, Marco Denegri, Silvia G. Priori, Carlo Camilloni   +8 more
doaj   +1 more source

Understanding the regulation of hERG potassium channel in the myometrium at the time of labour

We have shown that a potassium channel known as hERG falls precipitously at the time of term labour and that blocking this channel causes powerful uterine contractions.

core  

LncRNA MALAT1/Calpain-1 Axis in ATO Induced hERG Channel Deficiency [PDF]

Caichuan Yan,* Yuexin Li,* Xiaoxu Li, Yang Li, Yuhao Zhang, Jinyang Sun, Qirui Ding, Xin Zhao, Baoxin Li Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, People’s Republic of China*These authors contributed ...
Li X, Li Y, Zhang Y, Yan C, Ding Q, Li B, Sun J, Zhao X   +7 more
core