Results 101 to 110 of about 1,529,868 (197)

Nitazene opioids and the heart: Identification of a cardiac ion channel target for illicit nitazene opioids

Journal of Molecular and Cellular Cardiology Plus
The growing use of nitazene synthetic opioids heralds a new phase of the opioid crisis. However, limited information exists on the toxic effects of these drugs, aside from a propensity for respiratory depression.
Jules C. Hancox, Yibo Wang, Caroline S. Copeland, Henggui Zhang, Stephen C. Harmer, Graeme Henderson   +5 more
doaj   +1 more source

Fluorescent analogues of BeKm-1 with high and specific activity against the hERG channel

Toxicon: X, 2019
Peptidic toxins that target specifically mammalian channels and receptors can be found in the venom of animals. These toxins are rarely used directly as tools for biochemical experiments, and need to be modified via the attachment of chemical groups (e.g.
Lucie Vasseur, Alain Chavanieu, Stéphanie Combemale, Cécile Caumes, Rémy Béroud, Michel De Waard, Pierre Ducrot, Jean A. Boutin, Gilles Ferry, Thierry Cens   +9 more
doaj   +1 more source

Non-cardiovascular drugs that inhibit hERG-encoded potassium channels and risk of sudden cardiac death

, 2010
Background Virtually all QTc-prolonging drugs act by blocking the human ether a go-go-related gene (hERG)-encoded potassium channels (hERG channels), whereas not all QTc-prolonging drugs are associated with an increased risk of serious cardiac ...
Straus, SMJM (Sabine), Witteman, JCM, Stricker, Bruno, Sturkenboom, MCJM, Noord, Charlotte, B. H. C. Stricker, J. C. M. Witteman, C. van Noord, M. C. J. M. Sturkenboom, S. M. J. M. Straus   +9 more
core   +1 more source

Psilocybin Therapy of Psychiatric Disorders Is Not Hampered by hERG Potassium Channel-Mediated Cardiotoxicity. [PDF]

Int J Neuropsychopharmacol, 2022
Hackl B, Todt H, Kubista H, Kubista H, Hilber K, Koenig X.   +5 more
europepmc   +1 more source

Quantification of hERG Potassium Channel Block from the ECG

, 2017
Blood potassium concentration ([K+]blood) influences the ECG T-wave morphology. T-wave slope-to-amplitude ratio (TS/A) has been shown to be correlated with [K+]blood, suggesting that it is a metric for the repolarizing IKr current, which flows through ...
J. de Bie, D. W. Mortara, W. B. Chiu, C. Corsi, S. Severi, Stefano Severi, Brian Chiu, Cristiana Corsi, Johan De Bie, David Mortara   +9 more
core   +1 more source

Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant. [PDF]

Cell Mol Life Sci, 2021
Al-Moubarak E, Shiels HA, Zhang Y, Du C, Hanington O, Harmer SC, Dempsey CE, Hancox JC.   +7 more
europepmc   +1 more source

Second-generation antipsychotics – Cardiac ion channel modulation and QT interval disturbances: A review

Biomolecules & Biomedicine
Second-generation antipsychotics (SGAs) are frequently prescribed in psychiatry due to their efficacy and improved tolerability compared to first-generation agents.
Orhan Erkan, Ayse Suna Dai, Nihal Ozturk, Semir Ozdemir   +3 more
doaj   +1 more source

Association between the serum concentrations and mutational status of IL-8, IL-27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer. [PDF]

Oncol Lett, 2021
Abid MN, Qadir FA, Salihi A.
europepmc   +1 more source

In Situ Visualization of hERG Potassium Channel via Dual Signal Amplification

, 2018
Dysfunction of the human ether-a-go-go related gene (hERG)-encoded potassium channel is identified as a major cause of the long QT syndrome, a marker for lethal cardiac arrhythmia.
Jing-Juan Xu (1400707), Xue-Jiao Yang (3859969), Kai Zhang (102844), Hong-Yuan Chen (1400701)   +3 more
core   +1 more source

In silico modelling--pharmacophores and hERG channel models

, 2005
In computational drug design, modelling studies are undertaken following two main strategies that depend on which information is available. If experimental data exist only for the molecules displaying the biological property of interest, a so-called ...
RECANATINI, MAURIZIO, CAVALLI, ANDREA, MASETTI, MATTEO   +2 more
core