Results 81 to 90 of about 12,393 (207)

Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. [PDF]

, 1998
A new superfamily of K+ channels has emerged in the past 2 years. Notable for possessing two pore-forming P domains in each subunit, members of the superfamily have been recognized through phylogeny from micro-organisms to humans. Four subfamilies of two
Goldstein, SA, Ilan, N, Pausch, MH, Wang, KW   +3 more
core  

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Modulation of HERG potassium channel function by drug action

Annals of Medicine, 2004
Repolarization of cardiomyocytes is mainly performed by the rapid component of the delayed rectifier potassium current, I(Kr), which is encoded by the human ether-a-go-go-related gene (HERG). Inhibition of HERG potassium currents by class III antiarrhythmic drugs causes lengthening of the cardiac action potential, which produces a beneficial ...
Dierk, Thomas, Christoph A, Karle, Johann, Kiehn   +2 more
openaire   +2 more sources

Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1

Journal of Arrhythmia, 2016
Background: The human ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly activating delayed-rectifier potassium channels. Mutations in this gene cause long QT syndrome type 2 (LQT2).
Takehito Kondo, Ichiro Hisatome, Shouichi Yoshimura, Endang Mahati, Tomomi Notsu, Peili Li, Kazuhiko Iitsuka, Masaru Kato, Kazuyoshi Ogura, Junichiro Miake, Takeshi Aiba, Wataru Shimizu, Yasutaka Kurata, Shinji Sakata, Naoe Nakasone, Haruaki Ninomiya, Akira Nakai, Katsumi Higaki, Yasushi Kawata, Yasuaki Shirayoshi, Akio Yoshida, Kazuhiro Yamamoto   +21 more
doaj   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Fast and Slow Voltage Sensor Movements in HERG Potassium Channels [PDF]

The Journal of General Physiology, 2002
HERG encodes an inwardly-rectifying potassium channel that plays an important role in repolarization of the cardiac action potential. Inward rectification of HERG channels results from rapid and voltage-dependent inactivation gating, combined with very slow activation gating.
Smith, Paula L., Yellen, Gary
openaire   +3 more sources

TXCA‐Mediated Synthesis of Halogenated 4‐Aminocoumarins Derivatives Under Mild Conditions and In Silico Evaluation Against Alzheimer's Disease‐Related Protein Targets

ChemistrySelect, Volume 11, Issue 16, 27 April 2026.
A green and sustainable protocol for the halogenation of 4‐aminocoumarins using trihaloisocyanuric acids was developed, affording compounds with the predicted potential to inhibit protein targets associated with Alzheimer's disease. ABSTRACT A highly efficient and selective protocol for the halogenation of the C─H bond of 4‐aminocoumarin derivatives is
Maryelle A. G. de Carvalho, Vinicius C. Alves, Lara M. Flores, Carlos V. Doerner, Tácia K. Hall, Cristiani F. Bortolatto, Louis P. Sandjo, José S. S. Neto, Antonio L. Braga, Francisco F. de Assis   +9 more
wiley   +1 more source

Mechanisms underlying probucol-induced hERG-channel deficiency

Drug Design, Development and Therapy, 2015
Yuan-Qi Shi,1,* Cai-Chuan Yan,1,* Xiao Zhang,1 Meng Yan,1 Li-Rong Liu,1 Huai-Ze Geng,1 Lin Lv,1 Bao-Xin Li1,21Department of Pharmacology, Harbin Medical University, 2State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin, Heilongjiang ...
Shi YQ, Yan CC, Zhang X, Yan M, Liu LR, Geng HZ, Lv L, Li BX   +7 more
doaj  

Eag and HERG potassium channels as novel therapeutic targets in cancer

World Journal of Surgical Oncology, 2010
Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential ...
Bali Anish, Shaw Robert, Sowter Heidi, Asher Viren, Khan Raheela   +4 more
doaj   +1 more source

QTc Interval Prolongation and Associated Drug Therapy in Hospitalized Older Adults

Journal of the American Geriatrics Society, EarlyView.
Francesco Fantin, Sara Fiorini, Anna Giani, Luana Giacobbe, Elena Zoico, Gianluca Trifirò, Rocco Micciolo, Mauro Zamboni   +7 more
wiley   +1 more source