Results 71 to 80 of about 1,529,868 (197)
The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity
Epilepsia Open, Volume 11, Issue 5, Page 1395-1412, October 2026.Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia +4 more
wiley +1 more source
DataSheet1_Structural modeling of hERG channel–drug interactions using Rosetta.pdf
, 2023 The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target.
Igor Vorobyov (1900024) +8 more
core +1 more source
Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Lubeluzole is a benzothiazole derivative that has shown neuroprotective properties in preclinical models of ischemic stroke. However, clinical research on lubeluzole is now at a standstill, since lubeluzole seems to be associated with the acquired long QT syndrome and ventricular arrhythmias.
Gualdani, Roberta +6 more
openaire +7 more sources
Journal of Arrhythmia, Volume 42, Issue 5, October 2026.At clinically relevant plasma concentrations, stimulant medications produced minimal effects on conduction velocity but modulated automaticity and repolarization in a hiPSC‐derived cardiomyocyte (hiPSC‐CM) model. These findings provide a foundation for future investigations of stimulant‐associated cardiac safety and support the utility of hiPSC‐CM ...
Alia Arslanova +5 more
wiley +1 more source
DataSheet1_Structural modeling of the hERG potassium channel and associated drug interactions.PDF
, 2022 The voltage-gated potassium channel, KV11.1, encoded by the human Ether-à-go-go-Related Gene (hERG), is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential.
Igor Vorobyov (1900024) +7 more
core +1 more source
Inhibition of hERG Potassium Channels by Celecoxib and Its Mechanism
PLoS ONE, 2011 Celecoxib (Celebrex), a widely prescribed selective inhibitor of cyclooxygenase-2, can modulate ion channels independently of cyclooxygenase inhibition. Clinically relevant concentrations of celecoxib can affect ionic currents and alter functioning of neurons and myocytes.
Roman V Frolov +2 more
openaire +3 more sources
Eag and HERG potassium channels as novel therapeutic targets in cancer
World Journal of Surgical Oncology, 2010 Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential ...
Bali Anish +4 more
doaj +1 more source
MedComm, Volume 7, Issue 10, October 2026.Tripterine liposome (TP‐lipo) exerts anti‐pancreatic ductal adenocarcinoma (PDAC) effects through direct suppression of tumor cells and modulation of the tumor microenvironment (TME). TP‐lipo induces apoptosis and inhibits the clonogenicity, migration, and invasion of KPC cells in vitro.
Lirui Tang +8 more
wiley +1 more source
Global analysis reveals families of chemical motifs enriched for HERG inhibitors.
PLoS ONE, 2015 Promiscuous inhibition of the human ether-à-go-go-related gene (hERG) potassium channel by drugs poses a major risk for life threatening arrhythmia and costly drug withdrawals.
Fang Du +4 more
doaj +1 more source