Results 91 to 100 of about 1,529,868 (197)
hERG channel agonist NS1643 strongly inhibits invasive astrocytoma cell line SMA-560.
PLoS ONEGliomas are highly malignant brain tumours that remain refractory to treatment. Treatment is typically surgical intervention followed by concomitant temozolomide and radiotherapy; however patient prognosis remains poor.
Kieran W Benn +6 more
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Frontiers in Pharmacology, 2018 The hERG (human ether-a-go-go-related gene) encoded potassium ion (K+) channel plays a major role in cardiac repolarization. Drug-induced blockade of hERG has been a major cause of potentially lethal ventricular tachycardia termed Torsades de Pointes ...
Saba Munawar +7 more
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Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action
Drug Design, Development and Therapy, 2015 Nadine Vonderlin,1 Fathima Fischer,1 Edgar Zitron,1,2 Claudia Seyler,1 Daniel Scherer,1 Dierk Thomas,1,2 Hugo A Katus,1,2 Eberhard P Scholz1 1Department of Internal Medicine III, University Hospital Heidelberg, 2German Centre for Cardiovascular ...
Vonderlin N +7 more
doaj
Ginkgo biloba Extract and Ginkgolide Antiarrhythmic Potential by Targeting hERG and ICa-L Channel
Journal of Pharmacological Sciences, 2013 We investigated the effects of Ginkgo biloba extract (GBE) and ginkgolide (GLD) on human ether-a-go-go-related gene (hERG)-encoded K+ channels and its underlying mechanisms in the hERG-HEK293 cell line by determining GBE- and GLD-induced changes in ...
Xin Zhao +8 more
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Data_Sheet_1_Aggregation-Induced Emission: Lighting Up hERG Potassium Channel.docx
, 2019 Based on the scaffold of astemizole and E-4031, four AIE light-up probes (L1–L4) for Human Ether-a-go-go-Related Gene (hERG) potassium channel were developed herein using AIE fluorogen(TPE).
Tingting Liu (267387) +4 more
core +1 more source
Endocytic Regulation of Voltage-Dependent Potassium Channels in the Heart
Journal of Pharmacological Sciences, 2012 Understanding the regulation of cardiac ion channels is critical for the prevention of arrhythmia caused by abnormal excitability. Ion channels can be regulated by a change in function (qualitative) and a change in number (quantitative).
Kuniaki Ishii, Ikuo Norota, Yutaro Obara
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The molecular determinants of R-roscovitine block of hERG channels.
PLoS ONE, 2019 Human ether-à-go-go-related gene (Kv11.1, or hERG) is a potassium channel that conducts the delayed rectifier potassium current (IKr) during the repolarization phase of cardiac action potentials. hERG channels have a larger pore than other K+channels and
Bryan Cernuda +7 more
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, 2009 The hERG potassium channel is highly related to severe cardiac side effects. With the technique of homology modelling it is possible to model the homo tetrameric subunits of the hERG channel in the closed and open state, using KcsA and KirBac1.1 as well ...
A. WINDISCH +5 more
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Fluorogenic Probe for the Human Ether-a-Go-Go-Related Gene Potassium Channel Imaging
, 2016 The first small-molecule fluorogenic probe A1 for imaging the human Ether-a-go-go-Related Gene (hERG) potassium channel based on the photoinduced electron transfer (PET) off–on mechanism was described herein.
Lupei Du (1376673) +5 more
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Calculation of absolute binding free energies between the hERG channel and structurally diverse drugs [PDF]
, 2019 The human ether-a-go-go-related gene (hERG) encodes a voltage-gated potassium channel that plays an essential role in the repolarization of action potentials in cardiac muscle.
Terada, Tohru +3 more
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