Results 121 to 130 of about 12,393 (207)

Early Steps in C-Type Inactivation of the hERG Potassium Channel. [PDF]

J Chem Inf Model, 2023
Pettini F, Domene C, Furini S.
europepmc   +1 more source

Nitazene opioids and the heart: Identification of a cardiac ion channel target for illicit nitazene opioids

Journal of Molecular and Cellular Cardiology Plus
The growing use of nitazene synthetic opioids heralds a new phase of the opioid crisis. However, limited information exists on the toxic effects of these drugs, aside from a propensity for respiratory depression.
Jules C. Hancox, Yibo Wang, Caroline S. Copeland, Henggui Zhang, Stephen C. Harmer, Graeme Henderson   +5 more
doaj   +1 more source

Fluorescent analogues of BeKm-1 with high and specific activity against the hERG channel

Toxicon: X, 2019
Peptidic toxins that target specifically mammalian channels and receptors can be found in the venom of animals. These toxins are rarely used directly as tools for biochemical experiments, and need to be modified via the attachment of chemical groups (e.g.
Lucie Vasseur, Alain Chavanieu, Stéphanie Combemale, Cécile Caumes, Rémy Béroud, Michel De Waard, Pierre Ducrot, Jean A. Boutin, Gilles Ferry, Thierry Cens   +9 more
doaj   +1 more source

Psilocybin Therapy of Psychiatric Disorders Is Not Hampered by hERG Potassium Channel-Mediated Cardiotoxicity. [PDF]

Int J Neuropsychopharmacol, 2022
Hackl B, Todt H, Kubista H, Kubista H, Hilber K, Koenig X.   +5 more
europepmc   +1 more source

Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant. [PDF]

Cell Mol Life Sci, 2021
Al-Moubarak E, Shiels HA, Zhang Y, Du C, Hanington O, Harmer SC, Dempsey CE, Hancox JC.   +7 more
europepmc   +1 more source

Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. [PDF]

, 2006
MinK-related peptide 2 (MiRP2) and Kv3.4 subunits assemble in skeletal muscle to create subthreshold, voltage-gated potassium channels. MiRP2 acts on Kv3.4 to shift the voltage dependence of activation, speed recovery from inactivation, suppress ...
Abbott, Geoffrey W, Butler, Margaret H, Goldstein, Steve AN   +2 more
core   +1 more source

Genotype-Phenotype Relationships in Long QT Syndrome : Role of Mental Stress, Adrenergic Activity and a Common KCNH2 Polymorphism [PDF]

, 2006
Long QT syndrome is a congenital or acquired arrhythmic disorder which manifests as a prolonged QT-interval on the electrocardiogram and as a tendency to develop ventricular arrhythmias which can lead to sudden death.
Paavonen, Kristian
core  

Regulation of Kv11.1 Potassium Channel C-Terminal Isoform Expression by the RNA-Binding Proteins HuR and HuD

, 2018
The potassium voltage-gated channel subfamily H member 2 (KCNH2) gene encodes the Kv11.1 potassium channel, which conducts the rapidly activating delayed rectifier current in the heart.
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core  

Association between the serum concentrations and mutational status of IL-8, IL-27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer. [PDF]

Oncol Lett, 2021
Abid MN, Qadir FA, Salihi A.
europepmc   +1 more source

Activation Gating of hERG Potassium Channels [PDF]

Journal of Biological Chemistry, 2007
Rachael M. Hardman, Phillip J. Stansfeld, Sarah Dalibalta, Michael J. Sutcliffe, John S. Mitcheson   +4 more
openaire   +1 more source