Results 141 to 150 of about 1,529,868 (197)

Voltage sensor gating charge transfer in a hERG potassium channel model. [PDF]

Biophys J, 2014
Colenso CK, Cao Y, Sessions RB, Hancox JC, Dempsey CE.   +4 more
europepmc   +1 more source

Modeling hERG Channel Liability: From Structural Insight to Highly Accurate Qualitative and Quantitative Models. [PDF]

J Chem Inf Model
Sun H, Wang Y, Shen M.
europepmc   +1 more source

Synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG. [PDF]

Acta Pharmacol Sin
Ottosson NE, Frampton DJA, Pipatpolkai T, Norman C, Karlsson U, Jauregi-Miguel A, Venter M, Sridhar A, Larsson HP, Gréen H, Liin SI.   +10 more
europepmc   +1 more source

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking. [PDF]

Biochem Pharmacol, 2016
Zhang Y, Colenso CK, El Harchi A, Cheng H, Witchel HJ, Dempsey CE, Hancox JC.   +6 more
europepmc   +1 more source

Variable expressivity in long QT syndrome type 2 rabbits defines a low threshold for therapeutic <i>I</i>_Kr restoration. [PDF]

Am J Physiol Heart Circ Physiol
Turan NN, Welton A, Lu Y, Kim TY, Roder K, Sengun E, Kabakov AY, Bronk P, Martinez-Moreno R, Baggett B, Tai D, Kang D, Killeen M, Merley A, Kurnick S, Helwig L, Odening KE, Choi BR, Koren G.   +18 more
europepmc   +1 more source

Integrated Screening Cascades for Ion-Channel Drug Discovery: Linking Structure, Electrophysiology, Safety Pharmacology, and Human-Relevant Models. [PDF]

Int J Mol Sci
Seo Y.
europepmc   +1 more source

Screening the Tox21 Compound Library for Chemicals That Stimulate the Adrenergic β1 Receptor. [PDF]

Chem Res Toxicol
Adesina PA, Zhang L, Sukhawanit C, Wood S, Zhao J, Li Z, Sakamuru S, Ferguson SS, Hsieh JH, Reif DM, Huang R, Xia M.   +11 more
europepmc   +1 more source

Structure-Activity Relationship Analysis and hERG Liability Assessment of Second-Generation Antibiofilm Compounds Active Against Salmonella. [PDF]

ChemMedChem
Sorge A, Bennett AN, Gregory SE, Cole AL, Woolard KJ, Nemeth AM, Crow AH, Melander RJ, Gunn JS, Melander C.   +9 more
europepmc   +1 more source

Establishment and Characterization of a Stable hERG Cell Line for High-Throughput Drug Cardiac Safety Screening. [PDF]

Int J Mol Sci
Lu H, Guo Q, Qiu Q, Hu J.
europepmc   +1 more source

<i>In vitro</i> generation of human embryonic stem cell-derived heart organoids possessing physiological ion currents. [PDF]

Regen Ther
Lee J, Matsukawa H, Sawada K, Kaneko R, Ishino F.   +4 more
europepmc   +1 more source