Results 91 to 100 of about 355,175 (361)

Estimation of heritability for milk urea and genetic correlations with milk production traits in 3 Danish dairy breeds [PDF]

, 2023
Bart Buitenhuis, Nina Aagaard Poulsen
openalex   +1 more source

Negative phenotypic and genetic associations between copulation duration and longevity in male seed beetles [PDF]

, 2009
Reproduction can be costly and is predicted to trade-off against other characters. However, while these trade-offs are well documented for females, there has been less focus on aspects of male reproduction.
AA Hoffmann, B Zwaan, C Mühlhäuser, CW Fox, D Houle, D J Hosken, D Reznick, DA Dewsbury, DA Roff, DA Roff, DJ Hodgson, DJ Hosken, DJ Hosken, DS Falconer, E A Brown, FJ Messina, G Arnqvist, GA Schwarzenbach, GJ Kenagy, HS Crudgington, IT MacBean, J Hunt, J Hunt, JS Kotiaho, L Gay, L Partridge, LW Simmons, LW Simmons, M Ackermann, M Edvardsson, M Edvardsson, M Gasser, M Lynch, M Tatar, MD Tuttle, ME Czesak, MH Gromko, MJG Gage, MJG Gage, MR Rose, MT Siva-Jothy, N Wedell, NG Prasad, OY Martin, OY Martin, P E Eady, P Eady, PE Eady, R Thornhill, R Vasudev, S Paukku, S Pitnick, S Wigby, S-B Horng, T Burk, T Chapman, T Clutton-Brock, T Miyatake, T Price, T Tregenza, TA Mousseau, UM Savalli, UM Savalli, UM Savalli, WA Becker, WA Van Voorhies, WG Hill, WJ Bailey, WU Blanckenhorn, Y Qi   +69 more
core   +1 more source

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits

Nature Genetics, 2017
Multiple methods have been developed to estimate narrow-sense heritability, h2, using single nucleotide polymorphisms (SNPs) in unrelated individuals. However, a comprehensive evaluation of these methods has not yet been performed, leading to confusion ...
L. Evans, R. Tahmasbi, S. Vrieze, G. Abecasis, Sayantani Das, S. Gazal, D. W. Bjelland, Teresa R. de Candia, M. Goddard, B. Neale, Jian Yang, P. Visscher, M. Keller   +12 more
semanticscholar   +1 more source

Reference‐Guided Chromosome‐by‐Chromosome de novo Assembly at Scale Using Low‐Coverage High‐Fidelity Long‐Reads with HiFiCCL

Advanced Science, EarlyView.
HiFiCCL, as the first assembly framework specifically designed for low‐coverage high‐fidelity reads, improves the assembly quality of existing assemblers and also enhances downstream applications such as large structural variant (SV) detection (>10 000 bp), synteny analysis, pangenome graph construction, and graph‐based individual‐specific germline SVs
Zhongjun Jiang, Weihua Pan, Runtian Gao, Heng Hu, Wentao Gao, Murong Zhou, Yu‐Hang Yin, Zhipeng Qian, Shuilin Jin, Guohua Wang   +9 more
wiley   +1 more source

Accurate and efficient estimation of local heritability using summary statistics and the linkage disequilibrium matrix

Nature Communications, 2023
Existing SNP-heritability estimators that leverage summary statistics from genome-wide association studies (GWAS) are much less efficient (i.e., have larger standard errors) than the restricted maximum likelihood (REML) estimators which require access to
Hui Li, Rahul Mazumder, Xihong Lin
doaj   +1 more source

How to read “heritability” in the recipe approach to natural selection [PDF]

, 2013
There are two ways evolution by natural selection (ENS) is conceptualized in the literature. One provides a ‘recipe’ for ENS incorporating three ingredients: variation, differences in fitness and heritability.
Bourrat, Pierrick
core  

Unsupervised empirical Bayesian multiple testing with external covariates

, 2008
In an empirical Bayesian setting, we provide a new multiple testing method, useful when an additional covariate is available, that influences the probability of each null hypothesis being true.
Ferkingstad, Egil, Frigessi, Arnoldo, Kong, Augustine, Rue, Håvard, Thorleifsson, Gudmar   +4 more
core   +2 more sources

Mining Pure, Strict Epistatic Interactions from High-Dimensional Datasets: Ameliorating the Curse of Dimensionality [PDF]

, 2012
Background: The interaction between loci to affect phenotype is called epistasis. It is strict epistasis if no proper subset of the interacting loci exhibits a marginal effect.
Richard E. Neapolitan, Xia Jiang, Xiaofeng Wang   +2 more
core   +3 more sources

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

Heritability of autism spectrum disorders: a meta‐analysis of twin studies

Journal of Child Psychology and Psychiatry and Allied Disciplines, 2015
Background The etiology of Autism Spectrum Disorder (ASD) has been recently debated due to emerging findings on the importance of shared environmental influences.
Beata Tick, P. Bolton, F. Happé, M. Rutter, F. Rijsdijk   +4 more
semanticscholar   +1 more source