Results 71 to 80 of about 99,486 (214)
Heritability estimation of diseases in case-control studies [PDF]
arXiv, 2016 In the field of genetics, the concept of heritability refers to the proportion of variations of a biological trait or disease that can be explained by genetic factors. Quantifying the heritability of a disease is a fundamental challenge in human genetics, especially when the causes are plural and not clearly identified.
arxiv
Genomic Heritability: What Is It?
PLOS Genetics, 2015 Whole-genome regression methods are being increasingly used for the analysis and prediction of complex traits and diseases. In human genetics, these methods are commonly used for inferences about genetic parameters, such as the amount of genetic variance among individuals or the proportion of phenotypic variance that can be explained by regression on ...
de los Campos, Gustavo +2 more
openaire +6 more sources
Parent-offspring regression to estimate the heritability of an HIV-1 trait in a realistic setup
Retrovirology, 2017 Background Parent-offspring (PO) regression is a central tool to determine the heritability of phenotypic traits; i.e., the relative extent to which those traits are controlled by genetic factors.
Nadine Bachmann +11 more
doaj +1 more source
Heritability Estimation in Matrix-Variate Mixed models -- A Bayesian Approach [PDF]
arXiv, 2015 Since the emergence of genome-wide association studies (GWASs), estimation of the narrow sense heritability explained by common single-nucleotide polymorphisms (SNPs) via linear mixed model approaches became widely used. As in most GWASs, most of the heritability analyses are performed using univariate approaches i.e.
arxiv
Comparative Study of Single-Trait and Multi-Trait Genomic Prediction Models
AnimalsConventional genomic selection models trait individually, neglecting complex trait interactions. Multi-trait models address this by considering genetic correlations, thus improving breeding value accuracy.
Xi Tang +4 more
doaj +1 more source
Indications of the Heritable Nature of Non-Susceptibility to Rous Sarcoma in Fowls [PDF]
, 1948 A. Greenwood, J. S. S. Blyth, J. G. Carr
openalex +1 more source
Improved polygenic risk prediction in migraine-first patients
The Journal of Headache and PainBackground Recent meta-analyses estimated 14.6% and 11.2% SNP-based heritability of migraine, compared to twin-heritability estimates of 30–60%. This study aimed to investigate heritability estimates in “migraine-first” individuals, patients for whom G43
Dora Torok +3 more
doaj +1 more source
Indian Journal of Animal Sciences, 2016 First lactation records of 493 Phule Triveni cows sired by 55 bulls on production traits, viz. first lactation 300- day or less milk yield (FL300DMY), first lactation length (FLL), first dry period (FDP) and reproduction traits like age at first calving
G S AMBHORE +5 more
doaj +1 more source
Science, 2013 A genome-wide association study reveals possible variants that influence the complex behavior of educational attainment. [Also see Report by Rietveld et al. ]
Flint, Jonathan, Munafò, Marcus
openaire +4 more sources
The Human Microbiome and the Missing Heritability Problem
Frontiers in Genetics, 2017 The “missing heritability” problem states that genetic variants in Genome-Wide Association Studies (GWAS) cannot completely explain the heritability of complex traits.
Santiago Sandoval-Motta +6 more
doaj +1 more source