Results 71 to 80 of about 251,536 (320)
Do aphids in Dutch sweet pepper greenhouses carry heritable elements that protect them against biocontrol parasitoids? [PDF]
, 2022 Mariska Beekman +6 more
openalex +1 more source
Advanced Science, EarlyView.MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang +12 more
wiley +1 more source
Unsupervised empirical Bayesian multiple testing with external covariates
, 2008 In an empirical Bayesian setting, we provide a new multiple testing method, useful when an additional covariate is available, that influences the probability of each null hypothesis being true.
Ferkingstad, Egil +4 more
core +2 more sources
Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children [PDF]
, 2022 Fiona A. Hagenbeek +16 more
openalex +1 more source
Advanced Science, EarlyView.These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao +11 more
wiley +1 more source
Heritability in frontotemporal tauopathies
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019 Introduction Exploring the degree of heritability in a large cohort of frontotemporal lobar degeneration with tau‐immunopositive inclusions (FTLD‐tau) and determining if different FTLD‐tau subtypes are associated with stronger heritability will provide ...
Shelley L. Forrest +9 more
doaj +1 more source
Implications of avoiding overlap between training and testing data sets when evaluating genomic predictions of genetic merit [PDF]
, 2010 The aim of this study was to evaluate and quantify the importance of avoiding overlap between training and testing subsets of data when evaluating the effectiveness of predictions of genetic merit based on genetic markers.
Amer, P. R., Banos, G.
core +1 more source
Heritability curves: A local measure of heritability in family models
Statistics in Medicine, 2020 Classical heritability models for family data split the phenotype variance into genetic and environmental components. For instance, the ACE model in twin studies assumes the phenotype variance decomposes as a2 + c2 + e2, representing (additive) genetic effects, common (shared) environment, and residual environment, respectively.
Geir D. Berentsen +4 more
openaire +4 more sources
Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk
Advanced Science, EarlyView.Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu +10 more
wiley +1 more source
Optimizing mating schemes in fish breeding [PDF]
, 2007 The optimal contribution selection method and the simulated annealing algorithm were used to maximize the genetic gain and reduce inbreeding in fish breeding populations.
D'Agaro, E. +3 more
core +2 more sources