Results 91 to 100 of about 100,982 (338)

A Stable Heroin Analogue That Can Serve as a Vaccine Hapten to Induce Antibodies That Block the Effects of Heroin and Its Metabolites in Rodents and That Cross-React Immunologically with Related Drugs of Abuse

Journal of Medicinal Chemistry, 2017
An improved synthesis of a haptenic heroin surrogate 1 (6-AmHap) is reported. The intermediate needed for the preparation of 1 was described in the route in the synthesis of 2 (DiAmHap).
A. Sulima, R. Jalah, Joshua F. G. Antoline, Oscar B. Torres, Gregory H. Imler, J. Deschamps, Z. Beck, C. Alving, A. Jacobson, K. Rice, G. Matyas   +10 more
semanticscholar   +1 more source

Changing trends in drug overdose mortality in Spain, 2001–2022

Addiction, EarlyView.
Abstract Aim To measure the evolution of drug overdose mortality in Spain between 2001 and 2022. Design, Setting, Participants A repeated cross‐sectional observational study using nationwide mortality data from Spain, 2001–2022, among individuals aged 15–64 years.
Florencia Giné, Marta Donat, Juan Miguel Guerras, Gregorio Barrio, María José Belza, Julieta Politi, Enrique Regidor   +6 more
wiley   +1 more source

African Missionary Heroes and Heroines [PDF]

, 1919
H. K. W. Kumm
openalex   +1 more source

How changes in posttraumatic stress disorder (PTSD) severity mediate substance use disorder (SUD) severity during and after treatment for co‐occurring PTSD and SUD: Results from Project Harmony

Addiction, EarlyView.
Abstract Background and Aims Posttraumatic stress disorder (PTSD) commonly co‐occurs with substance use disorders (SUD). Comorbid PTSD and SUD (PTSD+SUD) is associated with greater severity and impairment and poorer treatment outcomes. Several interventions exist to treat PTSD, SUD and PTSD+SUD; however, research has yet to elucidate the indirect ...
Denise A. Hien, Jordan A. Gette, Shannon M. Blakey, Marilyn L. Piccirillo, Sudie E. Back, Alexandria G. Bauer, Chantel T. Ebrahimi, Robyn A. Ellis, Therese K. Killeen, Elizabeth A. Lehinger, Teresa López‐Castro, Sonya B. Norman, Lesia M. Ruglass, Tanya C. Saraiya, Lissette M. Saavedra, Antonio A. Morgan‐López   +15 more
wiley   +1 more source

Among people who use heroin, tobacco smoking and illegal drugs cause a similar number of premature deaths

Addiction, EarlyView.
Abstract Background and aims Most people who use heroin also smoke tobacco, but there is limited investment to reduce the prevalence of smoking in this group. This may be due to a perception that tobacco is less harmful than other substances and is a lower priority problem. Among people who use heroin in England, we aimed to compare tobacco smoking and
Dan Lewer, Harry Tattan‐Birch, Sharon Cox   +2 more
wiley   +1 more source

AN INVESTIGATION ON THE PHARMACOLOGICAL ACTION OF SOME NEW SUBSTITUTES FOR MORPHINE AND HEROIN [PDF]

, 1933
G. Norman Myers
openalex   +1 more source

An approach to heroin use disorder intervention within the South African context: A content analysis study

Substance Abuse Treatment, Prevention, and Policy, 2010
Background The field of heroin use disorder intervention has been in transition in South Africa since the outbreak of the heroin epidemic. Yet despite growing evidence of an association between heroin users' use of supplementary intervention services and
Fourie David, Rataemane Solomon T, dos Santos Monika ML, Trathen Bruce   +3 more
doaj   +1 more source

Book Review: African Missionary Heroes and Heroines [PDF]

, 1918
W. O. Carver
openalex   +1 more source

The effectiveness of Individual Placement and Support on vocational outcomes for patients with substance use disorders: A pragmatic superiority randomized controlled trial of Individual Placement and Support versus enhanced self‐help

Addiction, EarlyView.
Abstract Background and aim Unemployment rates among individuals with substance use disorders (SUD) are high, and evidence‐based vocational methods are lacking. Employment is important because it improves treatment outcomes and protects against relapse.
Eline Borger Rognli, Kristoffer Andreas Aamodt Andersen, Erlend Marius Aas, Silje Endresen Reme, June Ullevoldsæter Lystad, Marianne Riksheim Stavseth, Espen Ajo Arnevik   +6 more
wiley   +1 more source

Neuroinflammatory history results in overlapping transcriptional signatures with heroin exposure in the nucleus accumbens and alters responsiveness to heroin in male rats

Translational Psychiatry
Recent progress in psychiatric research has highlighted neuroinflammation in the pathophysiology of opioid use disorder (OUD), suggesting that heightened immune responses in the brain may exacerbate opioid-related mechanisms.
Gabriele Floris, Mary Tresa Zanda, Konrad R. Dabrowski, Stephanie E. Daws   +3 more
doaj   +1 more source