Results 121 to 130 of about 48,510 (233)

Free Flap Reconstruction of Xylazine‐Associated Wounds: A Retrospective Review

Microsurgery, Volume 46, Issue 3, March 2026.
ABSTRACT Background Xylazine is a veterinary sedative that is added to illicit fentanyl to enhance its effects. Xylazine‐associated wounds differ from those found in patients who inject other drugs. They are larger and frequently involve deeper structures, such as bone.
Alan T. Makhoul, Carrie Z. Morales, Elizabeth B. Card, Matthew A. Goldshore, Jon B. Morris, L. Scott Levin, Jason D. Wink, John P. Fischer, Ines C. Lin, Stephen J. Kovach III   +9 more
wiley   +1 more source

Incidents of sudden death during restraint of agitated individuals in Sweden between 1992 and 2024

Journal of Forensic Sciences, Volume 71, Issue 2, Page 821-836, March 2026.
Abstract Restraint‐related sudden deaths in agitated individuals raise complex questions at the intersection of medicine and law. Hyperactive delirium with extreme agitation as well as positional asphyxia due to restraint have been proposed to account for these deaths. However, the exact physiological mechanisms responsible and to what extent restraint
Alexander Tyr, Erik Lindeman, Fredrik Tamsen, Ingemar Thiblin, Brita Zilg   +4 more
wiley   +1 more source

Upper Limb Wound Profile in Patients Who Inject Heroin and Fentanyl Mixed With Xylazine. [PDF]

Hand (N Y)
Dos Santos AK, Sisroe Dos Santos TA, Doddala B, Zabel D.   +3 more
europepmc   +1 more source

Drug Use After Emergency Department‐Initiated Injectable Buprenorphine: A Secondary Analysis of the ED‐INNOVATION Ancillary Safety and Feasibility Trial

Academic Emergency Medicine, Volume 33, Issue 3, March 2026.
ABSTRACT Study Objective To characterize opioid and nonopioid drug use in the week following emergency department (ED)‐initiated extended‐release buprenorphine (XR‐BUP) treatment using both self‐reported data and urine drug screens (UDS). Methods This study uses data collected during a nonrandomized clinical trial of patients with untreated opioid use ...
Ethan Cowan, Gail D'Onofrio, Jeanmarie Perrone, Erik Anderson, James Dziura, Kathryn Hawk, Andrew Herring, Ryan McCormack, Manali Phadke, Elizabeth A. Samuels, David A. Fiellin   +10 more
wiley   +1 more source

Association Between Heroin Use and Depression: NHANES 2005-2018. [PDF]

Addict Biol
Li B, Yang Z, Zhang X, Yang M, Qiu H, Ren Y.   +5 more
europepmc   +1 more source

Context features influence alcohol reward and motivation

Alcohol, Clinical and Experimental Research, Volume 50, Issue 3, March 2026.
The alcohol intake environment can exert powerful long‐term effects on alcohol motivation and relapse through alcohol‐context associative learning. In this study in mice, we determined that alcohol‐context learning depends upon the specific sensory and spatial features of the context.
Surya Pandey, Courtney A. Miller
wiley   +1 more source

Commonalities and differences in trait-like, risky, and utilitarian decision-making styles between abstinent heroin-dependent individuals and their siblings. [PDF]

Front Psychiatry
Yan WS, Lan Y, Liu SJ.
europepmc   +1 more source

Psilocybin and Ibogaine in Cocaine‐Seeking: Extinction Enhancement Without Relapse Prevention

Addiction Biology, Volume 31, Issue 3, March 2026.
Using a preclinical model of cocaine self‐administration, we examined the effects of psilocybin and ibogaine on extinction learning and relapse‐like behaviour. Both compounds, administered during the extinction phase, reduced cocaine seeking, indicating facilitation of extinction learning. However, neither treatment prevented cue‐induced reinstatement.
Isis Rita Anzel Koutrouli, Vojtěch Brejtr, Marek Schwendt, Kacper Witek, Chrysostomos Charalambous, Kristýna Aleksič, Nina Miniariková, Eva Lhotková, Martin Toman, Marek Nikolič, Radek Jurok, Petra Cihlářová, Vladimír Mazoch, Pavel Ryšánek, Martin Kuchař, Klára Šíchová, Tomáš Páleníček   +16 more
wiley   +1 more source

The Role of the Posterior Paraventricular Nucleus of the Thalamus in Food Deprivation-Induced Heroin-Seeking Relapse, in Male and Female Rats. [PDF]

Addict Biol
Borges C, Darecka A, Mainville-Berthiaume A, Ah-Yen E, Darvishmolla M, Courtemanche R, Shalev U.   +6 more
europepmc   +1 more source

The Buprenorphine Paradox: How Buprenorphine Triggers and Resolves Opioid Withdrawal

Addiction Biology, Volume 31, Issue 3, March 2026.
Buprenorphine can either precipitate or relieve opioid withdrawal depending on the timing of administration relative to full opioid agonist exposure. The article proposes that buprenorphine promotes mu‐opioid receptor (MOR) externalization and resensitization, creating a temporary signaling gap that explains precipitated withdrawal when full agonists ...
Mehdi Haghdoost, Jennifer LaBranche, Matthew Roberts, Victor W. Li, Jane J. Kim, James S. H. Wong, Pouya Azar   +6 more
wiley   +1 more source