Results 261 to 270 of about 170,139 (366)

Changing age profile and incidence of injecting drug use initiation among people in Australia who inject drugs: evidence from two national repeated cross-sectional studies. [PDF]

open access: yesLancet Reg Health West Pac
Price O   +11 more
europepmc   +1 more source

GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases

open access: yesMedComm, Volume 6, Issue 5, May 2025.
Within the GABAergic system, GABABRs are potential therapeutic targets for dealing multiple metabolic and binge eating disorders and food addiction. Allosteric modulators and small peptides targeting GABABR signaling pathways may be developed as attractive drug candidates that avoid the side effects of agents that directly bind these receptors ...
Weijie Xie   +10 more
wiley   +1 more source

Opioid overdoses following use of cocaine and methamphetamine in New South Wales, and the public health responses. [PDF]

open access: yesEmerg Med Australas
Chisholm P   +6 more
europepmc   +1 more source

Validation of a quantitative liquid chromatography/hybrid quadrupole‐linear ion trap MS/MS method for carfentanil and caffeine in a live human epidermis model

open access: yesRapid Communications in Mass Spectrometry, Volume 39, Issue S1, May 2025.
Rationale Carfentanil, an opioid 10K times more potent than morphine, has no licit clinical use. A powerful CNS depressant, it has been identified increasingly as the cause of overdose death in the United States. Because it is highly lipophilic, the law enforcement and medical communities have been concerned that responding personnel could be ...
Jonathan M. Oyler   +2 more
wiley   +1 more source

Trends in Necrotizing Fasciitis‐Associated Mortality in the United States 2003–2020: A CDC WONDER Database Population‐Based Study

open access: yesWorld Journal of Surgery, Volume 49, Issue 5, Page 1210-1218, May 2025.
Necrotizing fasciitis‐related age‐adjusted mortality rates per 10,000 stratified by sex in the United States from 1999 to 2020. ABSTRACT Background Necrotizing fasciitis (NF) is a severe and rapidly progressing soft tissue infection with high mortality rates.
Saad Khan   +8 more
wiley   +1 more source

Efficacy of cannabidiol alone or in combination with Δ‐9‐tetrahydrocannabinol for the management of substance use disorders: An umbrella review of the evidence

open access: yesAddiction, Volume 120, Issue 5, Page 813-834, May 2025.
Abstract Background and Aims Substance use disorders (SUD) lead to a high burden of disease, yet treatment options are limited. Cannabidiol (CBD) is being investigated as a potential therapeutic target due to its pharmacological properties and mode of action in the endocannabinoid system.
Bertrand Redonnet   +4 more
wiley   +1 more source

Is methamphetamine blood concentration in emergency department patients associated with the clinical picture?

open access: yesAddiction, Volume 120, Issue 5, Page 1007-1015, May 2025.
Abstract Aims This study aimed to describe clinical features and outcomes of patients presenting to the emergency department with analytically confirmed methamphetamine intoxication, to determine the blood concentration of methamphetamine and to test its association with clinical findings.
David McCutcheon   +7 more
wiley   +1 more source

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