Results 101 to 110 of about 317,227 (394)

Genotype–Phenotype Correlations, Mortality, and Clinical Insights in Keratitis–Ichthyosis–Deafness Syndrome: A Comprehensive Review and Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Keratosis–ichthyosis–deafness (KID) syndrome is a rare autosomal dominant ectodermal disease caused by mutations in the GJB2 gene, which encodes the gap junction protein Connexin 26 (Cx26) located on Chr. 13q12.11. This study presents the first mortality analysis associated with KID syndrome, focusing on a case report of a Latin American ...
Leslie Patrón‐Romero, Marco Antonio Hernández Lepe, José de Jesús Manríquez Torres, Diego Daniel Aguirre‐Gómez, Natsuo Hayashi‐Mercado, Genaro Rodríguez Uribe, Tadeo Cerón, María Ruiz‐Gamboa, Jesús Alonso Gándara‐Mireles, Ismael Lares‐Asseff, Verónica Loera‐Castañeda, Jorge Alvelais‐Palacios, Lucrecia Arzamendi‐Cepeda, Lidia Magdalena Castañeda‐González, Adolfo García‐Barrón, Francisco Yamal Quiroz Herrera, Francisco González‐Salazar, Horacio Almanza‐Reyes   +17 more
wiley   +1 more source

Optimal management of genital herpes: current perspectives

Infection and Drug Resistance, 2016
Andreas Sauerbrei Institute of Virology and Antiviral Therapy, German Consulting Laboratory for Herpes Simplex Virus and Varicella-Zoster Virus, Jena University Hospital, Friedrich-Schiller University of Jena, Jena, Germany Abstract: As one of the most ...
Sauerbrei A
doaj  

Psychosis in a 15-Year-Old Female with Herpes Simplex Encephalitis in a Background of Mannose-Binding Lecithin Deficiency

Case Reports in Psychiatry, 2017
Historically, psychotic disorder has been associated with viral infection. Herpes simplex infections and Epstein-Barr virus (EBV) among other viral infections have been implicated in psychotic disorder.
Kenneth Asogwa, Kwame Buabeng, Amarjit Kaur   +2 more
doaj   +1 more source

A Transcriptome‐Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey, Liam Gaziano, Preethi Eldi, Catherine Toben, Beben Benyamin, S. Hong Lee, Elina Hyppönen   +6 more
wiley   +1 more source

Maternal and neonatal infections of herpes simplex virus-1 and cytomegalovirus in Saudi Arabia

Journal of Infection and Public Health, 2020
It is common practice to screen for human cytomegalovirus (CMV) and herpes simplex virus (HSV) among women with infertility problems, recurrent abortion or exhibiting intrauterine growth restriction during pregnancy.
Raad M.M. Althaqafi, Mohamed Elrewiny, Ahmed S. Abdel-Moneim   +2 more
doaj  

A successfully treated case of herpes simplex encephalitis complicated by subarachnoid bleeding: a case report

Journal of Medical Case Reports, 2010
Introduction Histopathologically, herpes simplex virus type 1 causes hemorrhagic necrosis. Overt hemorrhage is infrequent in herpes simplex virus encephalitis but can lead to poor outcomes.
Okuchi Kazuo, Kawahara Makoto, Yata Noritaka, Kataoka Hiroshi, Tonomura Yasuyo, Ueno Satoshi   +5 more
doaj   +1 more source

The molecular basis of herpes simplex virus latency

FEMS Microbiology Reviews, 2012
Herpes simplex virus type 1 is a neurotropic herpesvirus that establishes latency within sensory neurones. Following primary infection, the virus replicates productively within mucosal epithelial cells and enters sensory neurones via nerve termini.
M. Nicoll, J. Proença, S. Efstathiou
semanticscholar   +1 more source

Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy

Annals of Neurology, EarlyView.
Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal, Sabine E. Olie, Michel van Weeghel, Bauke V. Schomakers, Frédéric M. Vaz, I‐PACE Study Group, Diederik van de Beek, Matthijs C. Brouwer   +7 more
wiley   +1 more source

Ligand-based drug design against Herpes Simplex Virus-1 capsid protein by modification of limonene through in silico approaches

Scientific Reports
The pharmacological effects of limonene, especially their derivatives, are currently at the forefront of research for drug development and discovery as well and structure-based drug design using huge chemical libraries are already widespread in the early
Md. Rezaul Islam, Md. Shafiqul Islam Sovon, Ummy Amena, Miadur Rahman, Md. Eram Hosen, Ajoy Kumer, Mohammed Bourhia, Yousef A. Bin Jardan, Samir Ibenmoussa, Gezahign Fentahun Wondmie   +9 more
doaj   +1 more source

Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice

Nature Biotechnology, 2021
Di Yin, Sikai Ling, Dawei Wang, Yao Dai, Hao Jiang, Xujiao Zhou, S. Paludan, Jiaxu Hong, Yujia Cai   +8 more
semanticscholar   +1 more source