Results 71 to 80 of about 317,227 (394)

Effect of genital herpes on cervicovaginal HIV shedding in women co-infected with HIV AND HSV-2 in Tanzania. [PDF]

, 2013
To compare the presence and quantity of cervicovaginal HIV among HIV seropositive women with clinical herpes, subclinical HSV-2 infection and without HSV-2 infection respectively; to evaluate the association between cervicovaginal HIV and HSV shedding ...
David Mabey, Eligius Lyamuya, Gabriele Riedner, Helen A. Weiss, Jim Todd, Laurent Belec, Leonard Maboko, Mary Rusizoka, Michael Hoelscher, Michael Hoelscher, Richard Hayes, See Profile   +11 more
core   +10 more sources

Herpes simplex virus interferes with amyloid precursor protein processing [PDF]

, 2005
Background The early events underlying Alzheimer's disease (AD) remain uncertain, although environmental factors may be involved. Work in this laboratory has shown that the combination of herpes simplex virus type 1 (HSV1) in brain and carriage of the
Dobson, C.B., Itzhaki, R.F., Parkin, E.T., Shipley, S.J.   +3 more
core   +4 more sources

Optogenetic‐Controlled iPSC‐Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice

Advanced Science, EarlyView.
This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao, Lingxue Niu, Zhihao Wang, Di Dai, Shasha Tang, Xiaoding Ma, Zhenqiang Deng, Guiling Yu, Yang Zhou, Tao Yan, Xingwan Liu, Deqiang Kong, Linfeng Hu, Xiang Li, Junwei Zhao, Fengfeng Cai, Meiyan Wang, Haifeng Ye   +17 more
wiley   +1 more source

The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]

, 2016
Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris, Brown, James R., Charman, Matthew, Conn, Kristen L., Grant, Kyle, McFarlane, Steven, Tong, Lily, Wasson, Peter   +7 more
core   +1 more source

Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer

Advanced Science, EarlyView.
This review compares clinical outcomes, translational progress, and global funding trends across cancer phototherapies—photodynamic, photothermal, and photoimmunotherapy—and conventional immunotherapy. It highlights differences in treatment efficacy, clinical trial status, financial investment, and regulatory challenges, providing a comprehensive ...
Deepak S. Chauhan, Kun Shao, Roopa Hebbandi Nanjundappa, Daniel‐Jiajun Yu, Marianne Stanford, Huile Gao, Channakeshava Sokke Umeshappa   +6 more
wiley   +1 more source

RNA interference inhibits herpes simplex virus type 1 isolated from saliva samples and mucocutaneous lesions

Brazilian Journal of Infectious Diseases, 2014
The aim of this study was to evaluate the use of RNA interference to inhibit herpes simplex virus type-1 replication in vitro. For herpes simplex virus type-1 gene silencing, three different small interfering RNAs (siRNAs) targeting the herpes simplex ...
Amanda Perse da Silva, Juliana Freitas Lopes, Vanessa Salete de Paula   +2 more
doaj  

Herpes simplex type 1 pneumonitis and acute respiratory distress syndrome in a patient with chronic lymphatic leukemia: a case report

Journal of Medical Case Reports, 2017
Background Pulmonary pathogenicity of herpes simplex virus type 1 in patients in intensive care without classic immunosuppression as well as the necessity of antiviral treatment in the case of herpes simplex virus detection in respiratory specimens in ...
Miriam Luginbuehl, Alexander Imhof, Alexander Klarer   +2 more
doaj   +1 more source

Combining PIM‐2 and PARP1 Inhibitors Induces MICA Expression on Multiple Myeloma Cells to Activate NK Cells through NKG2D Binding

Advanced Science, EarlyView.
The findings suggest that the combination of PIM‐2 and PARP1 inhibitors can induce MICA expression on MM cells, thereby activating NK cells through NKG2D binding. This process may restore NK cell function and serve as a potential therapeutic approach for MM patients. Abstract While immunogenic death in tumor cells activates specific anti‐tumor T cells,
Zhaoyun Liu, Wenhui Lei, Xiaohan Liu, Hui Liu, Kai Ding, Jia Song, Rong Fu   +6 more
wiley   +1 more source

Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease

Medical Microbiology and Immmunology, 2014
Infection with herpes simplex viruses is one of the most ancient diseases described to affect humans. Infection with these viruses produces vexing effects to the host, which frequently recur.
Paula A. Suazo, Eduardo I Tognarelli, A. Kalergis, P. González   +3 more
semanticscholar   +1 more source

Purification of Herpes Simplex Virus

Journal of General Virology, 1974
Summary Herpes simplex virus was highly purified from host cell material with little loss of infectivity by the combination of isopycnic centrifuging in a three layered silica gradient and rate zonal centrifuging in dextran T 70 gradient. By layering three solutions of colloidal silica (24, 18 and 12%, w/v) on top of each other in the centrifuge tube ...
Jonas Blomberg, A. Vahlne
openaire   +3 more sources