Results 51 to 60 of about 108,460,457 (303)

Roles of p53 in Herpes Simplex Virus 1 Replication [PDF]

Journal of Virology, 2013
ABSTRACT p53 is a critical factor in the cellular response to a broad range of stress factors through its ability to regulate various cellular pathways. In this study, tandem affinity purification of transiently expressed herpes simplex virus 1 (HSV-1) regulatory protein ICP22 coupled with mass spectrometry-based proteomics ...
Yuhei, Maruzuru, Hikaru, Fujii, Masaaki, Oyama, Hiroko, Kozuka-Hata, Akihisa, Kato, Yasushi, Kawaguchi   +5 more
openaire   +2 more sources

Phosphate‐Engineered DNA Reporters Boost CRISPR‐Cas12a Trans‐Cleavage for Rapid and Sensitive Nucleic Acid Detection

Advanced Science, EarlyView.
We uncover dual CRISPR‐Cas12a trans‐cleavage activities: endonucleolytic cleavage and 3′→5′ exonucleolytic trimming of ssDNA reporters. Mechanism‐guided 3′‐phosphate engineering accelerates substrate cleavage while favoring endonucleolytic processing, enabling Phos‐CRISPR, a rapid (20 min), highly sensitive, and specific platform for nucleic acid ...
Rui Yang, Chong Guo, Minjie Pei, Jiongyu Zhang, Xin Guan, Shuo Zhang, Xingye Liu, Kurt T. Schalper, Lori Avery, Rocco LaSala, David Banach, Changchun Liu   +11 more
wiley   +1 more source

Risk of HSV-2 Acquisition Among Women with Bacterial Vaginosis: Systematic Review and Meta-Analysis

Viruses
Objective: Bacterial vaginosis is a dysbiosis of the vaginal microbiome, typically characterized by a loss of Lactobacillus. Lactobacillus plays a crucial role in vaginal immunity and protection against sexually transmitted infections.
Taylor N. Whitt, Alexis Heath, D’Atra J. Hill, Douglas K. Brubaker, Christina Farr Zuend   +4 more
doaj   +1 more source

An Atypic Herpes Encephalitis with Wallenberg’s Lateral Medullary Syndrome and CD Receptors Deficiency

Acta Medica, 2004
Herpes simplex encephalitis is a rare complication of Herpes virus infections. Innate immune mechanisms are the first line of defence encountered by invading infectious agents.
Ayşe Tunca, Nüket Bavbek
doaj   +1 more source

Risk factors for herpes simplex virus type 2 and HIV among women at high risk in northwestern Tanzania: preparing for an HSV-2 intervention trial. [PDF]

, 2007
OBJECTIVES: To determine prevalence of and risk factors for herpes simplex virus type 2 (HSV-2) and HIV among women being screened for a randomized, controlled trial of HSV suppressive therapy in northwestern Tanzania. METHODS: Two thousand seven hundred
Mugeye, Kokugonza, Hayes, Richard J, Balira, Rebecca, Knight, Louise, Ross, David, Changalucha, John, Weiss, Helen A, Baisley, Kathy, Watson-Jones, Deborah, Rusizoka, Mary, Everett, Dean   +10 more
core   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Activation of the Herpes Simplex Virus Type 1 Protease [PDF]

Journal of Biological Chemistry, 1995
The catalytic efficiency of the mature HSV-1 protease has been examined as a function of solvent composition. With the peptide substrate HTYLQASEKFKMWG-amide, the specificity constant (kcat/Km) at pH 7.5 for cleavage is 5.2 M-1 s-1. This value increases to 38 M-1 s-1 when 25% glycerol is present in the reaction mixture.
D L, Hall, P L, Darke
openaire   +2 more sources

Possible reasons for an increase in the proportion of genital ulcers due to herpes simplex virus from a cohort of female bar workers in Tanzania [PDF]

, 2007
Objectives: To determine trends in the prevalence and aetiological distribution of genital ulcer syndrome (GUS) in a cohort of female bar workers and to assess factors associated with these trends.Methods: An open cohort of 600 women at high risk of HIV ...
Riedner, Gabriele, Maboko, Leonard, MacLean, I., Mmbando, Donan, MacLean, I, Lyamuya, Eligius, Todd, Jim, Rusizoka, Mary, Hayes, Richard, Hoffmann, Oliver, Grosskurth, Heiner   +10 more
core   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Ligand-based drug design against Herpes Simplex Virus-1 capsid protein by modification of limonene through in silico approaches

Scientific Reports
The pharmacological effects of limonene, especially their derivatives, are currently at the forefront of research for drug development and discovery as well and structure-based drug design using huge chemical libraries are already widespread in the early
Md. Rezaul Islam, Md. Shafiqul Islam Sovon, Ummy Amena, Miadur Rahman, Md. Eram Hosen, Ajoy Kumer, Mohammed Bourhia, Yousef A. Bin Jardan, Samir Ibenmoussa, Gezahign Fentahun Wondmie   +9 more
doaj   +1 more source