Results 91 to 100 of about 16,394 (213)

Discovery of Novel Pyrido[2,3‐b]Pyrazine Human Cytomegalovirus Polymerase Inhibitors with Broad Spectrum Antiherpetic Activity and Reduced hERG Inhibition

ChemMedChem, Volume 20, Issue 6, March 15, 2025.
We designed and synthesized a small library of novel non‐nucleoside, polymerase inhibitors of herpesviruses with a pyrido[2,3‐b]pyrazines core. Compound 27, a representative of the library, were identified with reduced hERG inhibition, and broad spectrum antiherpetic activity.
Bing Bai, Appan Srinivas Kandadai, Mostofa Hena, Alexandr Belovodskiy, John Shen, Michael Houghton, James A. Nieman   +6 more
wiley   +1 more source

Epstein–Barr Virus Sequence Variations Among the Understudied Nasopharyngeal Carcinoma Patients of Diverse Ancestries in Southeast Asia

Journal of Medical Virology, Volume 97, Issue 3, March 2025.
ABSTRACT Epstein–Barr virus (EBV) is associated with cancers, including lymphomas and nasopharyngeal carcinoma (NPC). To date, risk variants for NPC were mainly identified from Chinese populations, which dominated the world's total number of cases.
Hwee Sze Tee, Jingtong Liang, Norazlin Abdul Aziz, Xiang Zhou, Hamidah Akmal Hisham, Ke‐En Tan, Yanhong Chen, Zuriani Burhanuddin, Johnny S. H. Kwan, Kwok‐Wai Lo, Faridah Hassan, Sha'ariyah bt Mohd Mokhtar, Alan Soo Beng Khoo, Miao Xu, Yat‐Yuen Lim, Lu Ping Tan   +15 more
wiley   +1 more source

IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS

Медицинская иммунология, 2014
. The study included patients with chronic uveitis caused by herpes simplex virus (HSV), or mixed HSV/ cytomegalovirus (CMV) infections. Deficiencies in CD3+ and CD4+ T lymphocytes and significant increase of CD8+ lymphocyte subpopulations were found in ...
M. D. Guliamova, A. P. Rizopulu, H. M. Kamilov, U. S. Faisieva, A. A. Umarova, F. Yu. Garib, T. U. Aripova   +6 more
doaj   +3 more sources

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

Activation and inhibition of sirtuins: From bench to bedside

Medicinal Research Reviews, Volume 45, Issue 2, Page 484-560, March 2025.
Abstract The sirtuin family comprises seven NAD+‐dependent enzymes which catalyze protein lysine deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic stability and gene expression and control key processes, including energetic metabolism, cell cycle, differentiation, apoptosis, and aging.
Francesco Fiorentino, Emanuele Fabbrizi, Antonello Mai, Dante Rotili   +3 more
wiley   +1 more source

A review of virus infections of cetaceans and the potential impact of morbilliviruses, poxviruses and papillomaviruses on host population dynamics [PDF]

, 1999
Viruses belonging to 9 families have been detected in cetaceans. We critically review the clinical features, pathology and epidemiology of the diseases they cause.
Raga Esteve, Juan Antonio, Van Bressem, Marie-Françoise, Van Waerebeek, Koen   +2 more
core   +2 more sources

Unveiling the causal link between herpes virus infection and cutaneous leukocytoclastic angiitis: Insights from Mendelian randomization analysis

Rheumatology &Autoimmunity, Volume 5, Issue 1, Page 50-57, March 2025.
This Mendelian randomization (MR) analysis aimed to assess the causal relationship between the Herpes virus (HSV, herpes simplex virus; HHV‐6, human herpesvirus 6; VZV, varicella‐zoster virus; CMV cytomegalovirus; EBV, Epstein‐Barr virus) and leukocytoclastic angiitis.
Heyi Zhang, Jinglei Xie, Yifei Wang, Ruolan Li, Ying Mao, Luyao Song, Zhenyang Yuan, Qinyi Su, Yuehong Huo, Xiaofeng Li, Shengxiao Zhang   +10 more
wiley   +1 more source

Infectious Laryngotracheitis Virus and Avian Metapneumovirus: A Comprehensive Review

Pathogens
Respiratory avian viral diseases significantly impact the world poultry sector, leading to notable economic losses. The highly contagious DNA virus, infectious laryngotracheitis virus, and the RNA virus, avian metapneumovirus, are well known for their ...
Jongsuk Mo, Jongseo Mo
doaj   +1 more source

Cytomegalovirus erosive gastritis in a healthy infant: update about a case [PDF]

, 2012
El citomegalovirus es un virus ADN de la familia Herpesviridae que puede afectar al tubo digestivo. Dentro de éste, las dianas de afectación suelen ser el colon, el esófago y el estómago.
Carabaño Aguado, I., Fortes Alen, J., La Orden Izquierdo, E., Manzarbeitia, Félix, Pelayo Baeza, F. J.   +4 more
core   +1 more source

Determination of the herpesviridae family of viruses in samples of periodontal tissues and study of immunological parameters in patients with inflammatory and dystrophic-inflammatory periodontal disease, associated with persistent herpes virus infection [PDF]

, 2014
Герпес-вірусні інфекції (ГВІ) є поширеними вірусними інфекціями людини, що спостерігається у населення всіх країн та кліматогеографічних зон, мають різноманітні клінічні прояви і у ряді випадків досить небезпечні для життя людини.
Волосовець, Т.М.
core