Results 121 to 130 of about 213,606 (312)

Assessing Anti-HCMV Cell Mediated Immune Responses in Transplant Recipients and Healthy Controls Using a Novel Functional Assay

Frontiers in Cellular and Infection Microbiology, 2020
HCMV infection, reinfection or reactivation occurs in 60% of untreated solid organ transplant (SOT) recipients. Current clinical approaches to HCMV management include pre-emptive and prophylactic antiviral treatment strategies. The introduction of immune
Charlotte J. Houldcroft, Sarah E. Jackson, Eleanor Y. Lim, George X. Sedikides, Emma L. Davies, Claire Atkinson, Megan McIntosh, Ester B. M. Remmerswaal, Ester B. M. Remmerswaal, Georgina Okecha, Frederike J. Bemelman, Frederike J. Bemelman, Richard J. Stanton, Matthew Reeves, Mark R. Wills   +14 more
doaj   +1 more source

Inhibition of a viral enzyme by a small-molecule dimer disruptor. [PDF]

, 2009
We identified small-molecule dimer disruptors that inhibit an essential dimeric protease of human Kaposi's sarcoma-associated herpesvirus (KSHV) by screening an alpha-helical mimetic library.
Arnold, Leggy A, Craik, Charles S, Guy, R Kiplin, Lazic, Ana, Lee, Gregory M, Roels, Christina M, Shahian, Tina, Velusamy, Priya   +7 more
core  

Primary replication and invasion of the bovine gammaherpesvirus BoHV-4 in the genital mucosae [PDF]

, 2017
Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus that is widespread in cattle. Ex vivo models with bovine genital tract mucosa explants were set up to study molecular/cellular BoHV-4-host interactions.
Bogado Pascottini, Osvaldo Américo, Li, Yewei, Nauwynck, Hans, Opsomer, Geert, Wei, Ruifang, Xie, Jiexiong, Yang, Bo   +6 more
core   +2 more sources

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems

Viruses, 2017
Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe disease that may lead to blindness.
Matthew R. Pennington, Eric C. Ledbetter, Gerlinde R. Van de Walle   +2 more
doaj   +1 more source

Herpesvirus Assembly and Egress [PDF]

Journal of Virology, 2002
Herpesvirus particles consist of four morphologically distinct structures, the core, capsid, tegument, and envelope. The inner nucleoprotein core comprising the linear double-stranded DNA genome is included in an icosahedral (T=16) capsid shell of 150 hexons and 12 pentons.
openaire   +3 more sources

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Seroprevalence of Kaposi Sarcoma–associated Herpesvirus and Other Serologic Markers in the Brazilian Amazon

Emerging Infectious Diseases, 2009
To determine the presence of Kaposi sarcoma–associated herpesvirus (KSHV) and other serologic markers, we tested serum specimens of 339 Amerindians, 181 rural non-Amerindians, and 1,133 urban blood donors (13 Amerindians) in the Brazilian Amazon.
Maria C. Nascimento, Laura M. Sumita, Vanda U. Souza, Helen A. Weiss, Juliane Oliveira, Melissa Mascheretti, Mariana Quiroga, Rodrigo A.R. Vela, Nuno R. Faria, Claudio S. Pannuti, Philippe Mayaud   +10 more
doaj   +1 more source

Speculations on the clinical significance of asymptomatic viral infections [PDF]

, 2016
A detailed understanding of asymptomatic chronic viral infections is critical to analyse their pathogenesis, assess the severity and burden of disease and, where required, optimize public health control measures.
Gentile, Giuseppe, Micozzi, Alessandra
core   +1 more source

Bezlotoxumab as Treatment for Recurrent/Chronic Clostridioides difficile Infection in Pediatric Stem Cell Transplant Recipients: A Multi‐Institutional Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clostridioides difficile infection (CDI) represents a significant health risk to pediatric stem cell transplant (SCT) patients. In these patients, recurrent CDI is common, requiring prolonged antibiotic usage and increased hospitalization. Bezlotoxumab, a monoclonal antibody that targets the toxin responsible for CDI, has demonstrated efficacy
Aaron E. Fan, Shaikha Alqahtani, Natalie Dailey Garnes, Priti Tewari, Demetrios Petropoulos, Sajad Khazal, Kris Mahadeo, Paige DePriest, Irtiza N. Sheikh   +8 more
wiley   +1 more source