Results 51 to 60 of about 824,760 (279)
Epidemiology and fitness effects of wood mouse herpesvirus in a natural host population [PDF]
, 2012 Rodent gammaherpesviruses have become important models for understanding human herpesvirus diseases. In particular, interactions between murid herpesvirus 4 and Mus musculus (a non-natural host species) have been extensively studied under controlled ...
Amy B. Pedersen +12 more
core +1 more source
Advanced Science, EarlyView.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
The host exosome pathway underpins biogenesis of the human cytomegalovirus virion
eLife, 2020 Human Cytomegalovirus (HCMV) infects over half the world's population, is a leading cause of congenital birth defects, and poses serious risks for immuno-compromised individuals.
Declan L Turner +4 more
doaj +1 more source
Advanced Science, EarlyView.This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun +19 more
wiley +1 more source
The bZIP Proteins of Oncogenic Viruses
Viruses, 2020 Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain.
Madeleine L. Stolz, Craig McCormick
doaj +1 more source
Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections
Frontiers in Cellular and Infection Microbiology, 2021 Herpesviruses utilize various host factors to establish latent infection, survival, and spread disease in the host. These factors include host cellular machinery, host proteins, gene expression, multiple transcription factors, cellular signal pathways ...
Kumari Asha, Neelam Sharma-Walia
doaj +1 more source
Further strategies for evaluating the etiological role of a tumor-associated herpesvirus in marine turtle fibropapillomatosis [PDF]
, 2001 In 1992, an interdisciplinary research team headquartered at the University of Florida began studies in key targeted areas of fibropapillomatosis (FP) etiology and pathogenesis.
Jacobson, Elliott, Klein, Paul A.
core
Multiple human herpesvirus-8 infection [PDF]
, 2003 In Malawian patients with Kaposi sarcoma (KS) and their relatives, we investigated nucleotide-sequence variation in human herpesvirus-8 (HHV-8) subgenomic DNA, amplified from oral and blood samples by use of polymerase chain reaction.
Beyari, MM +7 more
core +1 more source
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 Herpesvirus saimiri(saimiriine herpesvirus 2) is the classical prototype of the γ2–herpesviruses or rhadinoviruses, which also contains a human member, the Kaposi's sarcoma–associated herpesvirus. The T–lymphotropicHerpesvirus saimiriestablishes specific replicative and persistent conditions in different primate host species.
H, Fickenscher, B, Fleckenstein
openaire +2 more sources
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source