Results 121 to 130 of about 638,244 (260)

Acyclovir‐Resistant Herpes Simplex Virus in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant: A Case Series

Transplant Infectious Disease, EarlyView.
This retrospective case series of acyclovir‐resistant HSV infection in pediatric patients undergoing allogeneic HSCT discusses the clinical course, associated complications, and treatment, including side effects. We propose the first algorithm for investigating and managing acyclovir‐resistant HSV infections in pediatric HSCT recipients, highlighting ...
Jenna Nunn, Ahmed Ahmed, Srividhya Senthil, Oana Mirci‐Danicar, Denise Bonney, Claire Horgan, Omima Mustafa, Robert Wynn, Malcolm Guiver, Ramya Nataraj   +9 more
wiley   +1 more source

Human herpesvirus-8-encoded LNA-1 accumulates in heterochromatin- associated nuclear bodies

Journal of General Virology, 1999
Subnuclear distribution of the human herpesvirus-8 (HHV-8)- encoded nuclear protein LNA-1 was analysed at high resolution in body cavity (BC) lymphoma-derived cell lines, in cell hybrids between BC cells and various human and mouse cells and in freshly infected K562 and ECV cell lines.
Laszlo, Szekely, Csaba, Kiss, Karin, Mattsson, Elena, Kashuba, Katja, Pokrovskaja, Attila, Juhasz, Pia, Holmvall, George, Klein   +7 more
openaire   +2 more sources

HHV‐8/KSHV in Solid Organ Transplantation: Current Gaps of Knowledge and Future Directions

Transplant Infectious Disease, EarlyView.
Risk mitigation strategies, including donors/recipients screening, DNAemia monitoring in recipients at risk, CNI‐to‐mTOR inhibitors switch, antivirals, and rituximab for KICS, may mitigate the impact of HHV‐8/KSHV infection in SOT. This review provides an update on KICS, identifies research gaps, and summarizes advances in screening and management ...
Alessandra Mularoni, Andrea Cona, Malgorzata Mikulska, Francesca Pecoraro, Carlotta Piazza, Elda De Vita, Giada Pietrosi, Matteo Bulati, Tiziana Lazzarotto, Mario Luppi   +9 more
wiley   +1 more source

Structural Insights Into the Nuclear Import of Gallid Alphaherpesvirus 1 Large Tegument Protein. [PDF]

Microbiologyopen
The study identifies and characterizes a bipartite nuclear localization signal within the GaAHV‐1 UL36 large tegument protein, revealing its structural interaction with importin α/β1 and confirming a conserved mechanism of nuclear import through biochemical, crystallographic, and mutational analyses.
Nath BK, Swarbrick CMD, Blades R, Ariawan D, Tietz O, Alvisi G, Forwood JK, Sarker S.   +7 more
europepmc   +2 more sources

Protein chainmail variants in dsDNA viruses. [PDF]

, 2015
First discovered in bacteriophage HK97, biological chainmail is a highly stable system formed by concatenated protein rings. Each subunit of the ring contains the HK97-like fold, which is characterized by its submarine-like shape with a 5-stranded β ...
Chiou, Joshua, Zhou, Z Hong
core   +2 more sources

Prevalence and Characteristics of Feline Ulcerative Keratitis and Corneal Sequestra in a Referral Population and Comparison Between Brachycephalic and Nonbrachycephalic Cats

Veterinary Ophthalmology, EarlyView.
ABSTRACT Objectives To investigate the prevalence and characteristics of feline ulcerative keratitis (UK) and corneal sequestra (CS) in brachycephalic and nonbrachycephalic breeds. Animals Studied Brachycephalic and nonbrachycephalic cats. Procedures Cats diagnosed with UK or CS (Total, 392; UK, 290; CS, 102), between 2013 and 2022, were included ...
M. Frejlich, G. Payen
wiley   +1 more source

Active herpesviruses are associated with intensive care unit (ICU) admission in patients pulmonary infection and alter the respiratory microbiome

Frontiers in Microbiology
BackgroundThe Herpesviridae family contains several human-related viruses, which are able to establish colonizing and latency in the human body, posing a significant threat to the prognosis of patients.
Zhiguang Liu, Chun-jian Qi, Yujia Shi, Tianyu Li, Yuan Fang, Qian Zhang, Qian Zhang   +6 more
doaj   +1 more source

The extraordinary evolutionary history of the reticuloendotheliosis viruses [PDF]

, 2013
The reticuloendotheliosis viruses (REVs) comprise several closely related amphotropic retroviruses isolated from birds. These viruses exhibit several highly unusual characteristics that have not so far been adequately explained, including their extremely
A Katzourakis, A Katzourakis, A Stamatakis, AC van der Kuyl, AD Yoder, AL Hughes, AM Awad, AM Fadly, Anna Maria Niewiadomska, Bill Sugden, BR Burmester, C Feschotte, C Hertig, CG Ludford, CG Ludford, CN Dren, CN Dren, CN Dren, CR Parrish, CY Kang, CY Lin, DC Nickle, DH Huson, DH Ley, DJ McGeoch, DS Arathy, DW Trampel, E Prukner-Radovcic, EH Dearborn, F Abascal, F Rodriguez, FR Robinson, H Koyama, HC Carlson, HG Purchase, HM Koo, I Davidson, IS Diallo, IS Diallo, J Hanson, J Li, J Martin, JJ Solomon, JP Stoye, JP Vanderberg, JS McDougall, K Nyakatura, KA Schat, KM Moore, LA Terzian, LE Hayes, LJ Yu, LT Coggeshall, M Barbacid, M Garcia, MJ Peterson, MK Cook, ML Drew, MR Patel, MW Dimmic, MX Motha, N Ratnamohan, N Yuasa, P Singh, PE Miller, PS Paul, PS Sarma, Q Liu, R Crespo, R Gifford, R Isfort, RA Weiss, RB Franklin, RB Franklin, RJ Isfort, RL Witter, RL Witter, RL Witter, RM Corwin, Robert J. Gifford, SB Hitchner, SK Biswas, SL Kosakovsky Pond, T Barbosa, T Tadese, TJ Kim, TM Grimes, VN Kewalramani, W Trager, WG Conway, WH Cheng, Y Wang, Z Cheng, Z Cui, Z Yang, É Brumpt   +95 more
core   +3 more sources

Detection of Ursid Gammaherpesvirus 2 in Asiatic Black Bears (Ursus thibetanus) With Keratoconjunctivitis

Veterinary Ophthalmology, EarlyView.
ABSTRACT Objective To investigate the potential contribution of herpesvirus infection in the development of ocular surface disease in Asiatic black bears (Ursus thibetanus). Animals Studied Eight captive Asiatic black bears housed at a wildlife sanctuary were examined during routine health assessments.
Katharina Thieme, Marc Gölkel, J. Corinna Eule, Lesley Halter‐Gölkel, Dusan Kunec, Frank Göritz, Sina Feyer, Bich Ngoc Bui, Jakob Trimpert   +8 more
wiley   +1 more source

Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection

EMBO Reports
To globally profile circRNAs, we employ RNA-Sequencing paired with chimeric junction analysis for alpha-, beta-, and gamma-herpesvirus infection. We find circRNAs are, as a population, resistant to host shutoff. We validate this observation using ectopic
Sarah E Dremel, Takanobu Tagawa, Vishal N Koparde, Carmen Hernandez-Perez, Jesse H Arbuckle, Thomas M Kristie, Laurie T Krug, Joseph M Ziegelbauer   +7 more
doaj   +1 more source