Results 81 to 90 of about 733,583 (262)
Arthritis &Rheumatology, EarlyView.Objective The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common single nucleotide polymorphisms (SNPs) on a typical complex trait are mediated by trans effects that coalesce on expression of a relatively sparse set of core genes.
Athina Spiliopoulou +9 more
wiley +1 more source
Acyclovir Is Activated into a HIV-1 Reverse Transcriptase Inhibitor in Herpesvirus-Infected Human Tissues [PDF]
Cell Host & Microbe, 2008 For most viruses, there is a need for antimicrobials that target unique viral molecular properties. Acyclovir (ACV) is one such drug. It is activated into a human herpesvirus (HHV) DNA polymerase inhibitor exclusively by HHV kinases and, thus, does not suppress other viruses.
Beda Brichacek +16 more
openaire +4 more sources
Expert Perspective: Diagnosis and Treatment of Castleman Disease
Arthritis &Rheumatology, Accepted Article.Summary Castleman disease (CD) is a major diagnostic challenge for Rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y.C. Chen +2 more
wiley +1 more source
New research paradigms and agenda of human factors science in the intelligence era [PDF]
arXiv, 2022 This paper proposes the innovative concept of "human factors science" to characterize engineering psychology, human factors engineering, human-computer interaction, and other similar fields. Although the perspectives in these fields differ, they share a common approach: "human-centered design." In the AI era, the human-machine relationship presents a ...
arxiv
Rare Infectious Diseases: Detection and Clinical Implications
iLABMED, EarlyView.Rare infectious diseases are infections that are uncommon, have a low incidence, and are caused by newly emerging pathogens, cross‐species or ectopic infections, or host immunodeficiencies. The detection and diagnosis of rare infections is one of the main reasons for misdiagnosis and missed diagnosis.
Xin Qian +7 more
wiley +1 more source
IDCases, 2020 Central nervous system infection caused by Herpes simplex virus 1 remains a significant cause of morbidity and mortality in transplant patients. Additionally, the clinical implications of the recently discovered Human herpesvirus 6A are still under ...
Raquel Silva +3 more
doaj
Could autophagy dysregulation link neurotropic viruses to Alzheimer’s disease?
Neural Regeneration Research, 2019 Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer’s disease, a common form of dementia that afflicts a large percentage of elderly individuals.
Maria Anele Romeo +2 more
doaj +1 more source
Can language models handle recursively nested grammatical structures? A case study on comparing models and humans [PDF]
arXiv, 2022 How should we compare the capabilities of language models (LMs) and humans? I draw inspiration from comparative psychology to highlight some challenges. In particular, I consider a case study: processing of recursively nested grammatical structures. Prior work suggests that LMs cannot handle these structures as reliably as humans can.
arxiv
Further strategies for evaluating the etiological role of a tumor-associated herpesvirus in marine turtle fibropapillomatosis [PDF]
, 2001 In 1992, an interdisciplinary research team headquartered at the University of Florida began studies in key targeted areas of fibropapillomatosis (FP) etiology and pathogenesis.
Jacobson, Elliott, Klein, Paul A.
core
Human herpesvirus 8 – A novel human pathogen
Virology Journal, 2005 In 1994, Chang and Moore reported on the latest of the gammaherpesviruses to infect humans, human herpesvirus 8 (HHV-8) 1. This novel herpesvirus has and continues to present challenges to define its scope of involvement in human disease. In this review,
Edelman Daniel C
doaj +1 more source