Results 1 to 10 of about 1,529,869 (227)

Arginine inactivates human herpesvirus 2 and inhibits genital herpesvirus infection

International Journal of Molecular Medicine, 2012
Arginine, among the amino acids, has demonstrated unique properties, including suppression of protein-protein interactions and virus inactivation. We investigated the effects of arginine on the infectivity of human herpesvirus 2 (HHV-2) and the potential application of arginine as a chemotherapeutic agent against genital herpes.
A. Hajime Koyama, Sawako Minami, Hiroshi Irie, Tsutomu Arakawa, Yukiko Suzuki, Keiko Ikeda, Yoshihisa Sekino, Kazuko Tsujimoto, Hisashi Yamasaki   +8 more
openaire   +5 more sources

Review part 2: Human herpesvirus‐6 in central nervous system diseases [PDF]

Journal of Medical Virology, 2010
AbstractJ. Med. Virol. 82:1669–1678, 2010. © 2010 Wiley‐Liss, Inc.
Yao, Karen, Crawford, John, Komaroff, Anthony, Ablashi, Dharam, Jacobson, Steven   +4 more
openaire   +5 more sources

Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects [PDF]

Memórias do Instituto Oswaldo Cruz, 2018
BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding ...
Lima, Lyana Rodrigues Pinto, Araújo, Nathália Alves de, Guterres, Alexandro, Pilotto, José Henrique, Niel, Christian, Paula, Vanessa Salete de   +5 more
openaire   +5 more sources

Human Herpesvirus 8 infection may contribute to oxidative stress in diabetes type 2 patients [PDF]

BMC Research Notes, 2020
Abstract Objective To investigate the link between Human Herpesvirus 8 (HHV8) infection and plasma oxidative stress in patients with diabetes mellitus type 2 (DM2). Results Blood samples collected from DM2 and control subjects were screened for the presence of antibodies ...
Incani A, Marras L, Serreli G, Ingianni A, Pompei R, Deiana M, Angius F.   +6 more
openaire   +4 more sources

Human Herpesvirus-6 Infectious Meningitis With Lymphadenitis in an Immunocompetent Adult. [PDF]

Brain Behav
Human Herpesvirus‐6 infectious meningitis with lymphadenitis in an immunocompetent adult. CSF: cerebrospinal fluid; NGS: next‐generation sequencing; HHV‐6: Human herpes virus‐6 ABSTRACT Purpose Human Herpesvirus 6 (HHV‐6) infections are primarily observed in immunocompromised individuals, such as those with acquired immunodeficiency syndrome or organ ...
Xie Y, Zhang C, Ma M, Yin Z, Chen L, Yang Y, Wu S, Fan Y, Xu Y, He D.   +9 more
europepmc   +2 more sources

Human herpesvirus type 1 and type 2 disrupt mitochondrial dynamics in human keratinocytes [PDF]

Archives of Virology, 2018
Mitochondrial movement and distribution throughout the cytoplasm is crucial for maintaining cell homeostasis. Mitochondria are dynamic organelles but can be functionally disrupted during infection. Here, we show that the ubiquitous human pathogens HHV-1 and HHV-2 induce changes in the mitochondrial morphology and distribution in the early and late ...
Marcin Chodkowski, Izabela Serafińska, Joanna Brzezicka, Anna Golke, Anna Słońska, Małgorzata Krzyżowska, Piotr Orłowski, Piotr Bąska, Marcin W. Bańbura, Joanna Cymerys   +9 more
openaire   +3 more sources

Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene [PDF]

Journal of Virology, 1997
Here we demonstrate that open reading frame 16 (ORF16) of the oncogenic herpesvirus saimiri protects cells from heterologous virus-induced apoptosis. The BH1 and BH2 homology domains are highly conserved in ORF16, and ORF16 heterodimerizes with Bcl-2 family members Bax and Bak. However, ORF16 lacks the core sequence of the conserved BH3 homology domain,
Rollie J. Clem, S. Zou, M. L. Mayer, Michael A. Veliuona, Victor E. Nava, J M Hardwick, Emily H. Cheng   +6 more
openaire   +3 more sources

Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins [PDF]

Journal of Virology, 2015
ABSTRACT Human herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are large-genome DNA viruses that establish a persistent infection in sensory neurons and commonly manifest with recurring oral or genital erosions that transmit virus. HSV encodes 12 predicted glycoproteins that serve various functions, including cellular attachment, entry, and ...
Aaron A. R. Tobian, David M. Koelle, David M. Knipe, Susanna L. Lamers, Robert C. Colgrove, Jeffrey I. Cohen, Thomas C. Quinn, Ruchi M. Newman, Stuart C. Ray, Oliver Laeyendecker   +9 more
openaire   +2 more sources

Formalin‐fixed paraffin‐embedded (FFPE) samples help to investigate transcriptomic responses in wildlife disease

Molecular Ecology Resources, EarlyView., 2023
Abstract Infectious diseases impact numerous organisms. Knowledge of host‐pathogen interactions and host responses to infection is crucial for conservation and management. Obtaining this knowledge quickly is made increasingly possible by a variety of genomic approaches, yet, for many species the bottleneck to understanding this, remains access to ...
Allison K. Miller, Cara L. Brosnahan, Anjali Pande, Cindy F. Baker, Jemma L. Geoghegan, Jane Kitson, Neil J. Gemmell, Edwina J. Dowle   +7 more
wiley   +1 more source

Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B [PDF]

Viruses, 2022
Human herpesvirus 6B (HHV-6B) is a T-lymphotropic virus and the etiological agent of exanthem subitum. HHV-6B is present in a latent or persistent form after primary infection and is produced in the salivary glands or transmitted to this organ. Infected individuals continue to secrete the virus in their saliva, which is thus considered a source for ...
Hirohito Ogawa, Daisuke Fujikura, Hikaru Namba, Nobuko Yamashita, Tomoyuki Honda, Masao Yamada   +5 more
openaire   +4 more sources