Results 171 to 180 of about 629,421 (295)

Identification of Potential Ferroptosis Biomarkers in Multiple Myeloma via WGCNA and Experiments

Cancer Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Introduction Multiple myeloma is a common malignant tumor of the hematologic system, and genetic alterations play a crucial role in its occurrence and development. Ferroptosis is an oxidative and iron‐dependent programmed cell death, which has a strong correlation with tumor development.
Yifan Wang, Xing Xie, Mengyuan Gu, Yanting Zheng, Jing Wu, Qicai Wang, Zhian Ling, Ruolin Li   +7 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, and Immunogenicity of a BTLA Agonist Antibody (Venanprubart) in Healthy Participants, Patients with Systemic Lupus Erythematosus, and Patients with Psoriasis: Results From Three Phase 1 Studies

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Venanprubart (LY3361237), an agonist antibody to B and T lymphocyte attenuator (BTLA), was developed as a potential treatment for autoimmune disorders, including systemic lupus erythematosus (SLE) and psoriasis. We tested venanprubart in three human Phase 1 safety studies: a single ascending dose (SAD) study in healthy participants (1/2/5/15 ...
Andrew C. Vendel, Olivier Benichou, Ching‐Yun Chang, Gourab Datta, Andrea Ferrante, Indrajit Ghosh, Brian A. Moser, Susan E. Sweeney, Jennifer Witcher, Matthew D. Linnik   +9 more
wiley   +1 more source

Trends in Incidence and Survival of Patients With Primary Effusion Lymphoma in the United States: A Population Based Cohort Study

Hematological Oncology, Volume 44, Issue 1, January 2026.
ABSTRACT Primary effusion lymphoma (PEL) is a rare and aggressive B‐cell non‐Hodgkin lymphoma (NHL) that predominantly affects patients with human immunodeficiency virus infection and is strongly associated with human herpes virus 8 (HHV‐8) infection. Due to its rarity, the current understanding of PEL's epidemiology and management is largely derived ...
John L. Vaughn, Gardenia Taza, Malak Munir, Sravani Rimmalapudi, Narendranath Epperla   +4 more
wiley   +1 more source

Valaciclovir therapy for secondary suppression of immune response to herpesviruses: An exploratory study. [PDF]

PLoS Pathog
McGee K, Dowell A, Lauder S, Begum J, Chagoury O, Croft W, Middleton L, Sun Y, Zuo J, McManus R, Moss P.   +10 more
europepmc   +1 more source

The Role of Viral and Bacterial Infections in the Etiology of Behçet's Disease

Journal of Clinical Laboratory Analysis, Volume 40, Issue 1, January 2026.
Bacterial and viral pathogens may play a key role in Behçet's disease (BD) pathogenesis by triggering autoimmunity, molecular mimicry, or microbiome disruption. These infectious agents could initiate inflammatory pathways, contributing to BD's diverse clinical manifestations.
Mohsen Moghoofei, Hamid Pajavand, Razieh Shahbazi, Marzieh Rezaei, Elahe Taki   +4 more
wiley   +1 more source

HHV-8-Associated Hemophagocytic Lymphohistiocytosis in a HIV-Negative and Nontransplant Man: A Case Report and Literature Review. [PDF]

Case Rep Infect Dis
Wang Y, Hu J, Zhu F, Cheng L.
europepmc   +1 more source

Unraveling Cytomegalovirus Drug Resistance in Transplant Patients by Targeting Deep Sequencing

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Drug‐resistant cytomegalovirus (CMV) poses a major clinical challenge in transplant recipients, leading to treatment failure and increased morbidity. This study applied a next‐generation sequencing (NGS) approach to identify antiviral resistance mutations (ARMs) in 71 samples from 68 CMV‐positive patients who had undergone hematopoietic stem ...
Salvador Alemán, Juan Camacho, Vanessa Recio, Estrella Ruiz, Pilar Zamarrón, Jorge Anel, Montserrat Enjuto, David Tarragó   +7 more
wiley   +1 more source

Betaherpesvirus Incidence in Saliva Samples From Patients With Hematological Neoplasms: Frequency, Clinic and Diagnostic Insights

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Hematological neoplasms (HN) are disorders originating in blood cells that hold significant epidemiological importance. Treatments available for these conditions can induce immunosuppression, and it increases the risk of viral infections and reactivations, mainly by Human betaherpesviruses (HCMV, HHV‐6, and HHV‐7).
Ana Carolina Silva Guimarães, Jéssica Pereira Gonçalves, Nathália de Sousa Pereira, Flávia Freitas de Oliveira Bonfim, Katrini Guidolini Martinelli, Marla Karine Amarante, Sueli Fumie Yamada‐Ogatta, Laura Cinquini Franco, Ligia Carla Faccin Galhardi, Vanessa Salete de Paula   +9 more
wiley   +1 more source

Widespread presence of novel gammaherpesviruses in lagomorph species (Oryctolagus cuniculus, Lepus spp. and Ochotona alpina). [PDF]

Virol J
Matos MC, Abrantes J, Lopes AM.
europepmc   +1 more source

Molecular Variations in Glycoprotein B of Asian Human Cytomegalovirus: Potential Impact on Virus Entry and Immune Evasion in Ocular Diseases

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Human cytomegalovirus (HCMV)‐associated ocular diseases have gained increasing attention due to a recent rise in cases diagnosed in Asia. A glycoprotein encoded by the virus UL55 gene, glycoprotein B (gB), is essential for viral entry and a primary target for naturally‐produced antibodies and vaccine development.
Tantri Lestari, Nobuyo Yawata, Gabriel Gonzalez, Hiroko Miyadera, Daisuke Motooka, Yuko Imamura, Hiroya Oki, Yasuo Mori, Mariko Shirane, Seik‐Soon Khor, Yosuke Omae, Mihoko Shimada, Dyah Ayu Windy, Satoko Nakano, Hiroki Tsutsui, Shiori Kuramoto, Chihiro Fukui, Riku Nakamura, Satoshi Yamana, Toshikatsu Kaburaki, Hisashi Mashimo, Hiroshi Takase, Ryoji Yanai, Eiichi Hasegawa, Kensuke Shibata, Makoto Yawata, Katsushi Tokunaga, Nobuyuki Ohguro, Koh‐Hei Sonoda   +28 more
wiley   +1 more source