Results 41 to 50 of about 765 (178)

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Glass eels and viruses – a lesson learnt from stocking the eastern German Baltic Sea coast

Transboundary and Emerging Diseases, Accepted Article., 2022
Abstract Concerns about Anguillid herpesvirus 1 (AngHV‐1) in European eels, especially due to stocking measures, is increasingly coming into focus and raises questions regarding disease monitoring and prevention. In the past, stocking of AngHV‐1‐positive eels into waters assumed AngHV‐1‐free has led to a rapid increase of infected eels in the wild. For
Laura Kullmann, Mikolaj Adamek, Dieter Steinhagen, Ralf Thiel   +3 more
wiley   +1 more source

Ovine Herpesvirus 2 Glycoprotein B Complementation Restores Infectivity to a Bovine Herpesvirus 4 gB-Null Mutant

Pathogens
Ovine herpesvirus 2 (OvHV-2) and bovine herpesvirus 4 (BoHV-4) are gamma herpesviruses that belong to the genera Macavirus and Rhadinovirus, respectively.
Daniela D. Moré, Katherine N. Baker, Smriti Shringi, Reginaldo G. Bastos, Donal O’Toole, Gaetano Donofrio, Cristina W. Cunha   +6 more
doaj   +1 more source

Serum and milk levels of antibodies to bovine viral diarrhoea virus, bovine herpesvirus-1 and -4, and circulation of different bovine herpesvirus-4 genotypes in dairy cattle with clinical mastitis

Journal of Veterinary Research, 2023
Bovine viral diarrhoea virus (BVDV) and bovine herpesvirus (BoHV)-1 and -4 are important causes of respiratory diseases and reproductive disorders of dairy cattle worldwide.
Ataseven Veysel S., Ambarcıoğlu Pınar, Doğan Fırat   +2 more
doaj   +1 more source

Equine herpesvirus 1 and 4 infections: An update [PDF]

Veterinary Quarterly, 2002
Equine herpesvirus 1 (EHV1) and equine herpesvirus 4 (EHV4) are important ubiquitous equine viral pathogens, causing much damage to the horse industry. EHV1 strains are associated with respiratory disease, abortion, and paresis/paralysis, whereas EHV4 strains are predominantly associated with respiratory disease.
openaire   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.

PLoS Pathogens, 2012
Herpesviruses are ubiquitous pathogens that cause much disease. The difficulty of clearing their established infections makes host entry an important target for control.
Ricardo Milho, Bruno Frederico, Stacey Efstathiou, Philip G Stevenson   +3 more
doaj   +1 more source

Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)

Advanced Science, EarlyView.
ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang, Jiahao Ding, Si Chen, Lijie Yan, Shichao Ding, Lavonda Li, Junyi Sun, Haodong Liu, Tongge Li, Ning Liu, Mingji Wei, Xiaoyong Zhu, Xiaobo Zou, Shouqi Yuan, Xingcai Zhang   +14 more
wiley   +1 more source

Studies on the molecular biological peculiarities of bovine herpesvirus 4

Bulgarian Journal of Veterinary Medicine, 2020
Studies on the molecular biological features of bovine herpesvirus 4 (BHV 4) strains isolated in Bul-garia have been conducted. Two types of polymerase chain reaction have been developed and applied to confirm the gB and TK genes.
R. Peshev, I. Sirakov
doaj   +1 more source

The demonstration of a herpesvirus, related to bovine herpesvirus 1, in reindeer with ulcerative and necrotizing lesions of the upper alimentary tract and nose

Rangifer, 1990
In 11 male reindeer, all esposed to transportation stress, signs of conjunctivitis and later on ulcerative and necrotizing lesions of the mucosa of the nostrils and mouth were recorded. Blood and secretions from the nose were sampled.
G. Rockborn, C. Rehbinder, B. Klingeborn, M. Leffler, K. Klintevall, T. Nikkilä, A. Landén, M. Nordkvist   +7 more
doaj   +1 more source