Results 61 to 70 of about 551,240 (241)

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Structure and Antigenicity of Kaposi's Sarcoma-Associated Herpesvirus Glycoprotein B. [PDF]

Adv Sci (Weinh)
Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Fang XY, Sun C, Xie C, Cheng BZ, Lu ZZ, Zhao GX, Sui SF, Zeng MS, Liu Z.   +8 more
europepmc   +2 more sources

Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Human herpesvirus 8 (HHV-8, also called KSHV) is linked to the etiopathogenesis of Kaposi's sarcoma (KS), multicentric Castleman's disease (MCD), and primary effusion lymphoma (PEL). The universal presence of HHV-8 in early KS has not yet been shown.
Nicolas Dupin, C. Fisher, P. Kellam, S. Ariad, M. Tulliez, N. Franck, E. V. Marck, D. Salmon, I. Gorin, J. Escande, R. Weiss, K. Alitalo, C. Boshoff   +12 more
semanticscholar   +1 more source

Human Herpesvirus 8-Encoded Cytokines [PDF]

Future Virology, 2010
Human herpesvirus (HHV)-8, also called Kaposi's sarcoma-associated herpesvirus, was discovered in 1994 and was rapidly sequenced, revealing several unique and surprising features of its genetic makeup. Among these discoveries was the identification of the first viral homolog of IL-6 and three CC/beta-chemokine ligands (viral CCL-1, -2 and -3), not ...
openaire   +3 more sources

Salivary Lactoferrin Is Recognized by the Human Herpesvirus-8 [PDF]

Journal of Investigative Dermatology, 2005
Human herpesvirus-8 (HHV-8) is commonly detected in all epidemiologic forms of Kaposi's sarcoma. Despite the broad cellular tropism of HHV-8, studies on mucosal shedding of HHV-8 have shown that infectious particles are restricted to saliva isolated from the oropharynx.
Caroline Chauvel, Philippe Grange, Anne-Geneviève Marcelin, Vincent Calvez, Nicolas Dupin, Escande Jp   +5 more
openaire   +3 more sources

Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology

Eye &ENT Research, EarlyView.
Abstract Background To explore the material basis and action mechanism of the chemical component gene of pepper on presbycusis, and to provide a reference for the traditional Chinese medicine treatment of age‐related hearing loss (ARHL). Methods The chemical composition and action targets of traditional Chinese medicine flavor of pepper were searched ...
Yan Wang, Xiaoyu Song, Fengxin Yang, Huhuifen He, Kun Zhao, Jingjing Qiu, Limei Cui, Qiang Zhang, Limei Liu, Yan Sun   +9 more
wiley   +1 more source

First Diagnosed Case of Steroid-induced Kaposi's Sarcoma in Mongolia

Central Asian Journal of Medical Sciences, 2016
Objectives: Kaposi's sarcoma (KS) is a vascular neoplasm with four main types. We report the first diagnosed case of steroid-induced KS in a non-HIV patient in Mongolia.
Khandsuren Byamba, Ariunaa Munkhbayar, Oyuntsatsral Batsaikhan, Undram Sainzaya   +3 more
doaj   +1 more source

Sexual transmission and the natural history of human herpesvirus 8 infection.

New England Journal of Medicine, 1998
BACKGROUND Although human herpesvirus 8 (HHV-8) has been suspected to be the etiologic agent of Kaposi's sarcoma, little is known about its seroprevalence in the population, its modes of transmission, and its natural history.
Jeffrey N. Martin, D. Ganem, D. Osmond, K. Page-Shafer, D. Macrae, D. Kedes   +5 more
semanticscholar   +1 more source

Current Progress in Targeting Human Cytomegalovirus Infection

iLABMED, EarlyView.
This review highlights recent advances in the mechanisms by which human cytomegalovirus (HCMV) maintains its genome in infected cells, as well as the cellular factors and viral antigens that modulate viral reactivation, which reveal potential targets for addressing HCMV infection.
Yonggang Pei, Jun Chen
wiley   +1 more source

Is human herpesvirus 8 infection more common in men than in women? an updated meta-analysis

BMC Infectious Diseases
Background Clinically, most patients with Kaposi's sarcoma (KS) are male, and several direct and indirect mechanisms may underlie this increased susceptibility in men, Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-
Haibo Gong, Shuai Zhang, Jinfa Dou, Jing Chen   +3 more
doaj   +1 more source