Results 1 to 10 of about 127,921 (115)

Does the Zinc Finger Antiviral Protein (ZAP) Shape the Evolution of Herpesvirus Genomes?

Viruses, 2021
An evolutionary arms race occurs between viruses and hosts. Hosts have developed an array of antiviral mechanisms aimed at inhibiting replication and spread of viruses, reducing their fitness, and ultimately minimising pathogenic effects.
Yao-Tang Lin, Long-Fung Chau, Hannah Coutts, Matin Mahmoudi, Vayalena Drampa, Chen-Hsuin Lee, Alex Brown, David J. Hughes, Finn Grey   +8 more
doaj   +3 more sources

Genome evolution of Kaposi sarcoma-associated herpesvirus (KSHV)

Journal of Virology
Kaposi sarcoma (KS) is the most common cancer in people living with HIV (PLWH), particularly in sub-Saharan Africa (SSA), where Kaposi sarcoma herpesvirus (KSHV or human herpesvirus 8 [HHV-8]) is endemic. In KSHV endemic areas, the overall survival of KS
Razia Moorad, Alice Peng, Justin Landis, Linda J. Pluta, Patricio Cano, Angelica Juarez, Dirk P. Dittmer   +6 more
doaj   +3 more sources

A murine cytomegalovirus cell cycle regulator (m54.5p) evolved within the conserved viral DNA polymerase gene. [PDF]

PLoS Pathogens
Ribosome profiling (Ribo-seq) and transcription start site profiling recently unveiled hundreds of novel viral gene products in lytic murine cytomegalovirus (MCMV) infection.
Yan Zheng, Ivana Bertovic, Xiangming Han, Thomas Hennig, Adam W Whisnant, Stephanie Lamer, Andreas Schlosser, Vanda Juranic Lisnic, Penelope Kay-Fedorov, Lars Dölken, Manivel Lodha   +10 more
doaj   +2 more sources

Guinea Pig X Virus Is a Gammaherpesvirus [PDF]

Viruses
The Guinea Pig X Virus (GPXV), a newly identified gammaherpesvirus, provides an opportunity to study viral evolution and host–virus dynamics. This study characterizes the GPXV genome and investigates its phylogenetic relationships and divergence from ...
Vy Ngoc Yen Truong, Robert Ellis, Brent A. Stanfield   +2 more
doaj   +2 more sources

Functional and Structural Determinants of Long- and Short-Term Evolution of Herpesvirus Proteins [PDF]

Molecular Biology and Evolution
Diego Forni, Manuela Sironi, Hagai Tzachi   +2 more
exaly   +2 more sources

Genomes of Anguillid Herpesvirus 1 Strains Reveal Evolutionary Disparities and Low Genetic Diversity in the Genus Cyprinivirus

Microorganisms, 2021
Anguillid herpesvirus 1 (AngHV-1) is a pathogen of eels and a member of the genus Cyprinivirus in the family Alloherpesviridae. We have compared the biological and genomic features of different AngHV-1 strains, focusing on their growth kinetics in vitro ...
Owen Donohoe, Haiyan Zhang, Natacha Delrez, Yuan Gao, Nicolás M. Suárez, Andrew J. Davison, Alain Vanderplasschen   +6 more
doaj   +1 more source

γ-Herpesvirus load as surrogate marker of early death in HIV-1 lymphoma patients submitted to high dose chemotherapy and autologous peripheral blood stem cell transplantation. [PDF]

PLoS ONE, 2015
Autologous stem cell transplantation (ASCT) is a feasible procedure for human immunodeficiency virus-1 (HIV-1) lymphoma patients, whose underlying disease and intrinsic HIV-1- and ASCT-associated immunodeficiency might increase the risk for γ-herpesvirus
Chiara Pratesi, Stefania Zanussi, Rosamaria Tedeschi, Maria Teresa Bortolin, Renato Talamini, Maurizio Rupolo, Chiara Scaini, Giancarlo Basaglia, Matteo Di Maso, Mario Mazzucato, Ernesto Zanet, Umberto Tirelli, Mariagrazia Michieli, Antonino Carbone, Paolo De Paoli   +14 more
doaj   +1 more source

Structural variation turnovers and defective genomes: key drivers for the in vitro evolution of the large double-stranded DNA koi herpesvirus (KHV)

Peer Community Journal, 2022
Structural variations (SVs) constitute a significant source of genetic variability in virus genomes. Yet knowledge about SV variability and contribution to the evolutionary process in large double-stranded (ds)DNA viruses is limited. Cyprinid herpesvirus
Fuandila, Nurul Novelia, Gosselin-Grenet, Anne-Sophie, Tilak, Marie-Ka, Bergmann, Sven M, Escoubas, Jean-Michel, Klafack, Sandro, Lusiastuti, Angela Mariana, Yuhana, Munti, Fiston-Lavier, Anna-Sophie, Avarre, Jean-Christophe, Cherif, Emira   +10 more
doaj   +1 more source

Epidemiological and Phylogeographic Study of Equid Herpesviruses in Tunisia

Pathogens, 2022
Equid herpesvirus (EHV) is a contagious viral disease affecting horses, causing illness characterized by respiratory symptoms, abortion and neurological disorders. It is common worldwide and causes severe economic losses to the equine industry.
Chaima Badr, Oussama Souiai, Marwa Arbi, Imen El Behi, Mohamed S. Essaied, Ines Khosrof, Alia Benkahla, Ahmed Chabchoub, Abdeljelil Ghram   +8 more
doaj   +1 more source

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases

eLife, 2022
Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase (RNR) of Epstein-Barr virus. Here, we investigate the mechanistic conservation and
Sofia N Moraes, Jordan T Becker, Seyed Arad Moghadasi, Nadine M Shaban, Ashley A Auerbach, Adam Z Cheng, Reuben S Harris   +6 more
doaj   +1 more source