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Hesperetin: A Potent Antioxidant Against Peroxynitrite
Free Radical Research, 2004Peroxynitrite (ONOO-) is a reactive oxidant formed from superoxide (*O2(-)) and nitric oxide (*NO), that can oxidize several cellular components, including essential protein, non-protein thiols, DNA, low-density lipoproteins (LDL), and membrane phospholipids. ONOO- has contributed to the pathogenesis of diseases such as stroke, heart disease, Alzheimer'
Ji Young, Kim +3 more
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Hesperetin derivatives: Synthesis and anti-inflammatory activity
Bioorganic & Medicinal Chemistry Letters, 2016Sixteen novel hesperetin derivatives containing Mannich base moiety were designed and synthesized and their anti-inflammatory activities were evaluated by inhibiting tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in mouse RAW264.7 macrophages.
Qian-Qian, Wang +5 more
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Microbial metabolism. Part 13. Metabolites of hesperetin
Bioorganic & Medicinal Chemistry Letters, 2011The fungal culture, Mucor ramannianus (ATCC 2628) transformed hesperitin (1) to four metabolites: 4'-methoxy-5,7,8,3'-tetrahydroxyflavanone (8-hydroxyhesperetin) (2), 5,7,3',4'-tetrahydroxyflavanone (eriodictyol) (3), 4'-methoxy-5,3'-dihydroxyflavanone 7-sulfate (hesperetin 7-sulfate) (4) and 5,7,3'-trihydroxyflavanone 4'-O-α-quinovopyranoside ...
Wimal, Herath, Ikhlas Ahmad, Khan
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Hesperetin inhibits KSHV reactivation and is reversed by HIF1α overexpression
Journal of General Virology, 2021Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic virus, has two life cycle modes: the latent and lytic phases. KSHV lytic reactivation is important for both viral propagation and KSHV-induced tumorigenesis. The KSHV replication and transcription activator (RTA) protein is essential for lytic reactivation.
Wen-ying Long, Guo-hua Zhao, Yao Wu
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Production and characterization of Hesperetin nanosuspensions for dermal delivery
International Journal of Pharmaceutics, 2009Nanosuspensions of Hesperetin were produced using four different stabilizers, Poloxamer 188, Inutec SP1, Tween 80 and Plantacare 2000, possessing different mechanisms of stabilisation. The nanosuspensions were characterized with regard to size (photon correlation spectroscopy (PCS), laser diffractometry (LD)) and charge (zeta potential measurements). A
Prabhat R, Mishra +3 more
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Structure of (R,S)-hesperetin monohydrate
Acta Crystallographica Section C Crystal Structure Communications, 1987C 16 H 14 O 6 .H 2 O cristallise dans le systeme triclinique avec le groupe d'espace P1.
W. Shin, S. Kim, K. S. Chun
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The effect of hesperetin on ischemia–reperfusion injury in rat ovary
Archives of Gynecology and Obstetrics, 2014Hesperidin (HES), a citrus fruit extract, has beneficial effects on various ischemia/reperfusion (I/R) models. We aimed to evaluate the possible positive effects of hesperetin (HPT), an active metabolite of HES, on a rat ovarian I/R model.We divided 24 Wistar Albino rats into four groups.
Gencer, MERYEM +7 more
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Journal of Agricultural and Food Chemistry, 2011
In recent years much attention has been focused on the pharmaceutical relevance of bioflavonoids, especially hesperidin and its aglycon hesperetin in terms of their antioxidant and anti-inflammatory actions. However, the bioactivity of their metabolites, the real molecules in vivo hesperetin glucuronides/sulfates produced after ingestion, has been ...
Hsin-Ling, Yang +7 more
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In recent years much attention has been focused on the pharmaceutical relevance of bioflavonoids, especially hesperidin and its aglycon hesperetin in terms of their antioxidant and anti-inflammatory actions. However, the bioactivity of their metabolites, the real molecules in vivo hesperetin glucuronides/sulfates produced after ingestion, has been ...
Hsin-Ling, Yang +7 more
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Spectrophotometric Studies of the Interaction of Ruthenium with Hesperetin,
2008Hesperetin (5, 7, 3-trihydroxyl-4-methyl-flavanone) is a kind of flavonoid which occurs ubiquitously in plants, fruits, flowers and foods of plant origin (1). The interest in the hesperetin is due to its some biological and pharmacological activities, including antioxidant properties (2), inhibition of cancer development (3), etc.
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