Results 281 to 290 of about 124,493 (360)

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan

Aging Cell, Volume 24, Issue 8, August 2025.
In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam, Yang Yang, Mahbod Djamshidi, Sara Seifan, Nicholas S. Y. Ting, Joel Glover, Nicolas Touret, Paul M. K. Gordon, K. V. Vineetha Warriyar, Hokan Krowicki, Christine Kim Garcia, Sharon A. Savage, Aaron A. Goodarzi, Duncan M. Baird, Tara L. Beattie, Karl Riabowol   +15 more
wiley   +1 more source

SKI regulates rRNA transcription and pericentromeric heterochromatin to ensure centromere integrity and genome stability. [PDF]

Neoplasia
Pola-Véliz V, Carrero D, Sagredo EA, Inostroza V, Cappelli C, Rivas S, Bitrán M, Zambrano E, Gonzalez E, Morales F, Manterola M, Montecino M, Armisén R, Marcelain K.   +13 more
europepmc   +1 more source

Structural Basis of Heterochromatin Formation by Human HP1.

Molecules and Cells, 2018
Shinichi Machida, Y. Takizawa, Masakazu Ishimaru, Yukihiko Sugita, S. Sekine, J. Nakayama, M. Wolf, H. Kurumizaka   +7 more
semanticscholar   +1 more source

Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1095-1102, August 2025.
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 This original article is commented by Thompson on pages 975–976 of this issue. Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐
Russell C. Dale, Shekeeb Mohammad, Velda X. Han, Hiroya Nishida, Himanshu Goel, Stuart G. Tangye, Georgina Hollway, Esther Tantsis, Deepak Gill, Shrujna Patel, Chromatin Immune‐Brain Group, Michael Lonergan, Melanie Wong, Kavitha Kothur, Erica Tsang   +14 more
wiley   +1 more source

Patterns of crossover distribution in Drosophila mauritiana necessitate a re-thinking of the centromere effect on crossing over. [PDF]

Genetics
Hawley RS, Price A, Li H, Jagannathan M, Staber C, Hughes SE, Williams S, Perera A, Egidy RR, Lawlor A, Miller DE, Blumenstiel JP.   +11 more
europepmc   +1 more source

Phosphorylation Site Mutations in Heterochromatin Protein 1 (HP1) Reduce or Eliminate Silencing Activity [PDF]

, 2001
Tao Zhao, Tomasz Heyduk, Joel C. Eissenberg   +2 more
openalex   +1 more source

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF‐dependent activation of hypoxia‐inducible genes

The FEBS Journal, Volume 292, Issue 16, Page 4333-4352, August 2025.
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, Angeliki Karagiota, George Stamatakis, Martina Samiotaki, George Panayotou, George Simos, Georgia Chachami   +8 more
wiley   +1 more source

Histone variant H2A.W7 represses meiotic crossover formation in <i>Arabidopsis</i> heterochromatin. [PDF]

Proc Natl Acad Sci U S A
Kuo P, Tock AJ, Liu X, Topp SD, Zhong Z, Henderson IR, Lambing C.   +6 more
europepmc   +1 more source

Hybridization and gene expression: Beyond differentially expressed genes

Molecular Ecology, Volume 34, Issue 15, August 2025.
Abstract Gene expression has a key role in reproductive isolation, and studies of hybrid gene expression have identified mechanisms causing hybrid sterility. Here, we review the evidence for altered gene expression following hybridization and outline the mechanisms shown to contribute to altered gene expression in hybrids. Transgressive gene expression,
Anna Runemark, Emily C. Moore, Erica L. Larson   +2 more
wiley   +1 more source

Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque

Molecular Ecology, Volume 34, Issue 15, August 2025.
ABSTRACT Genetic variation that impacts gene regulation, rather than protein function, can have strong effects on trait variation both within and between species. Epigenetic mechanisms, such as DNA methylation, are often an important intermediate link between genotype and phenotype, yet genetic effects on DNA methylation remain understudied in natural ...
Christina E. Costa, Marina M. Watowich, Elisabeth A. Goldman, Kirstin N. Sterner, Josue E. Negron‐Del Valle, Daniel Phillips, Cayo Biobank Research Unit, Michael L. Platt, Michael J. Montague, Lauren J. N. Brent, James P. Higham, Noah Snyder‐Mackler, Amanda J. Lea   +12 more
wiley   +1 more source