Results 131 to 140 of about 1,614,552 (145)

Heterochromatin protein 1: a pervasive controlling influence

Cellular and Molecular Life Sciences, 2005
Heterochromatin protein 1 (HP1), a component of condensed chromatin, was discovered more than 10 years ago and subsequently found to play important roles in chromosomal biology and gene silencing. Consistent with the hypothesis that post-translational modifications of histones may functionally 'mark' DNA sequences, HP1 was found to bind to 'silent ...
Richard Festenstein, K. Hiragami
openaire   +3 more sources

A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin

Cytogenetic and Genome Research, 1994
The <i>Drosophila</i> HP1 gene contains a highly conserved sequence, the chromobox, which can be used to isolate HP1-like genes from both mouse (M31 and M32) and man (HSM1) (Singh et al., 1991). Here we report that a monoclonal antibody (MoAb) raised against the M31 protein recognises a 26-kDa protein in murine and human nuclear extracts ...
G W Butcher, Prim B. Singh, P S James, A Hutchings, F Hill, K A Wreggett   +5 more
openaire   +3 more sources

Schistosoma mansoni Heterochromatin Protein 1 (HP1) nuclear interactome in cercariae

Journal of Proteomics, 2021
Schistosoma mansoni causes schistosomiasis, which affects 240 million people, and 700 million people are living at risk of infection. Epigenetic mechanisms are important for transcriptional control and are well-known conserved transcriptional co-regulators in evolution, already described in mammal, yeast, protozoa and S.
Matheus de Souza Gomes, Ana Paula Masson, Silmara Marques Allegretti, Natália Silva da Trindade, Guilherme Pauperio Lanfredi, Enyara Rezende Morais, Gabriela Freitas Cruvinel, Giulliana Galdini Costa, Thaís Cunha de Sousa Cardoso, Vitor M. Faça, Fernanda Janku Cabral   +10 more
openaire   +3 more sources

Multiple Roles for Heterochromatin Protein 1 Genes inDrosophila

Annual Review of Genetics, 2009
Heterochromatin is the gene-poor, transposon-rich, late-replicating chromatin compartment that was first cytologically defined more than 70 years ago. The identification of heterochromatin protein 1 (HP1) paved the way for a molecular dissection of this important component of complex eukaryotic genomes.
Harmit S. Malik, Danielle Vermaak
openaire   +2 more sources

Gene regulation by human orthologs of Drosophila heterochromatin protein 1

Biochemical and Biophysical Research Communications, 2002
Heterochromatin protein 1 (HP1) functions in gene silencing, transcriptional regulation, and chromatin remodeling. Drosophila HP1 enhances position effect variegation and has also been shown to repress transcription of some euchromatic genes and activate some heterochromatic ones.
Howard J. Worman, Kyu-Kye Hwang
openaire   +3 more sources

The PpCMT chromomethylase affects cell growth and interacts with the homolog of LIKE HETEROCHROMATIN PROTEIN 1 in the moss Physcomitrella patens.

The Plant Journal, 2014
Chromomethylases (CMTs) are plant-specific cytosine DNA methyltransferases that are involved in maintenance of CpNpG methylation. In seed plants, histone methylation and interaction of CMT with LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) is essential for ...
Meenakshi Dangwal, S. Kapoor, M. Kapoor
semanticscholar   +1 more source

Heterochromatin protein 1: don’t judge the book by its cover!

Current Opinion in Genetics & Development, 2006
The name heterochromatin protein 1 (HP1) suggests that this small nuclear factor plays a role in forming heterochromatic domains. It was noticed years ago, however, that the distribution of HP1 on polytene chromosomes was not restricted to chromocenters or telomeres. HP1 was also found, reproducibly, along the euchromatic arms.
Florence Hediger, Susan M. Gasser
openaire   +3 more sources

The Heterochromatin Protein 1 Family is Regulated in Prostate Development and Cancer

Journal of Urology, 2008
The HP1 family of evolutionarily conserved proteins regulates heterochromatin packaging, in addition to a less defined role in the regulation of euchromatic genes. To examine the possible role of HP1 proteins in fetal prostate development and prostate cancer the protein expression of HP1alpha, beta and gamma was evaluated in human archival tissue ...
Susan K. Logan, Hongying Huang, Naoko Tanese, Peng Lee, Ellen Shapiro, Rachel Ruoff   +5 more
openaire   +3 more sources

Modulation of Heterochromatin Protein 1 Dynamics in Primary Mammalian Cells

Science, 2003
Heterochromatin protein 1 (HP1β), a key component of condensed DNA, is strongly implicated in gene silencing and centromeric cohesion. Heterochromatin has been considered a static structure, stabilizing crucial aspects of nuclear organization and prohibiting access to transcription factors.
Alain Verreault, Stamatis N. Pagakis, Richard Festenstein, Belaïd Sekkali, Kyoko Hiragami, Dimitris Kioussis, Debbie Lyon   +6 more
openaire   +3 more sources

Human autoimmune sera recognize a conserved 26 kD protein associated with mammalian heterochromatin that is homologous to heterochromatin protein 1 ofDrosophila

Chromosome Research, 1994
Immunofluorescence indicated that autoimmune sera from certain scleroderma/CREST patients, in addition to binding to the primary constrictions or centromeres, also labelled pericentromeric heterochromatin in mouse and human metaphase chromosomes. Immunoblotting has revealed that two conserved nuclear antigens are recognized by this CREST subgroup, one ...
Linda Nicol, Peter Jeppesen
openaire   +3 more sources