Results 131 to 140 of about 87,019 (296)

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Frontiers in Immunology, 2012
NETosis, the process wherein neutrophils release highly decondensed chromatin called neutrophil extracellular traps (NETs), has gained much attention as an alternative means of killing bacteria.
Marc eLeshner, Shu eWang, Carrie eLewis, Han eZheng, Xiangyun Amy Chen, Lorraine eSanty, Yanming eWang   +6 more
doaj   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Chromatin Regulation by HP1γ Contributes to Survival of 5-Azacytidine-Resistant Cells

Frontiers in Pharmacology, 2018
Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic ...
Satoshi Imanishi, Tomohiro Umezu, Chiaki Kobayashi, Tomohiko Ohta, Kazuma Ohyashiki, Junko H. Ohyashiki   +5 more
doaj   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Repo-Man/PP1 regulates heterochromatin formation in interphase

Nature Communications, 2017
Repo-Man is a chromosome-binding subunit of protein phosphatase 1 to regulate mitosis. Here, de Castro and colleagues show that Repo-Man also regulates heterochromatin during interphase, and regulates gene repression and chromatin organization.
Inês J. de Castro, James Budzak, Maria L. Di Giacinto, Lorena Ligammari, Ezgi Gokhan, Christos Spanos, Daniela Moralli, Christine Richardson, Jose I. de las Heras, Silvia Salatino, Eric C. Schirmer, Katharine S. Ullman, Wendy A. Bickmore, Catherine Green, Juri Rappsilber, Sarah Lamble, Martin W. Goldberg, Veronica Vinciotti, Paola Vagnarelli   +18 more
doaj   +1 more source

H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing

Epigenetics & Chromatin, 2011
Background Endogenous retroviruses (ERVs) are parasitic sequences whose derepression is associated with cancer and genomic instability. Many ERV families are silenced in mouse embryonic stem cells (mESCs) via SETDB1-deposited trimethylated lysine 9 of ...
Maksakova Irina A, Goyal Preeti, Bullwinkel Jörn, Brown Jeremy P, Bilenky Misha, Mager Dixie L, Singh Prim B, Lorincz Matthew C   +7 more
doaj   +1 more source

Hexavalents in spermatocytes of Robertsonian heterozygotes between Mus m. domesticus 2n 26 from the Vulcano and Lipari Islands (Aeolian Archipelago, Italy) [PDF]

, 2018
The size and shape of the chromosomes, as well as the chromosomal domains that compose them, are determinants in the distribution and interaction between the bivalents within the nucleus of spermatocytes in prophase I of meiosis.
Eliana Ayarza, Emanuela Solano, Ernesto Capanna, Jesús Page, Raúl Fernández-Donoso, Riccardo Castiglia, Soledad Berríos   +6 more
core   +3 more sources

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

A Reporter Platform to Study Therapy‐Induced Senescence in Live Cancer Cells

Small Methods, EarlyView.
This study describes the development and applications of a transgenic lamin‐based senescence reporter platform based on changes in lamin‐B1‐ and lamin‐A intensities during senescence‐induction. The reporter platform is a versatile tool, allowing to screen for and sort senescent cancer cells, allowing marker integration (for example incorporating IL6 ...
Jacinta van de Grint, Mengqi Huang, Ruben Sangers, Hanny Odijk, Thom Reuvers, Jose M. Heredia‐Genestar, Anja Raams, Tsung Wai Kan, Joris Pothof, Roland Kanaar, Maayke M.P. Kuijten   +10 more
wiley   +1 more source

Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth

Epigenetics & Chromatin, 2018
Background Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycle genes.
Kyohei Oyama, Danny El-Nachef, Chen Fang, Hidemi Kajimoto, Jeremy P. Brown, Prim B. Singh, W. Robb MacLellan   +6 more
doaj   +1 more source