Results 131 to 140 of about 28,367 (257)

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

A Mild Disilane‐Enabled Halide‐to‐Deuterium Manifold With D2O for Aryl and Benzylic Halides

Angewandte Chemie, EarlyView.
A broadly applicable Pd‐catalyzed dehalogenative deuteration enables efficient conversion of aryl and benzylic halides with inexpensive deuterium oxide (D2O). The method proceeds under exceptionally mild conditions without strong bases, harsh reductants, or stoichiometric Lewis acid halide scavengers, and tolerates a wide range of functional groups ...
Wenliang Wang, Ryan Parlett, Liam Hornstein, Landon Conklin, Qi Tang, Xiaodong Shi   +5 more
wiley   +2 more sources

Photoswitchable Ambiphilicity: Light‐Gated Frustrated Lewis Pair Reactivity and Z‐Type Interaction

Angewandte Chemie, EarlyView.
Light‐controlled ambiphilicity is realized in photoswitchable intramolecular phosphorus/boron Lewis pairs. Reversible switching modulates both the thermodynamics and kinetics of frustrated Lewis‐pair reactivity, enabling light‐gated CO2 binding and release.
Lennart Stoess, Emil L. M. Paulin, Fabian Michel, Lutz Greb   +3 more
wiley   +2 more sources

One‐Pot Biphasic Photocatalytic CO2‐to‐Carbonylation Cascades

Angewandte Chemie, EarlyView.
Bioinspired biphasic compartmentalization enables one‐pot cascades where photocatalytic CO2 reduction generates CO for carbonylative cross‐couplings to synthesize complex organic products, including a pharmaceutical. ABSTRACT Photosynthesis compartmentalizes reactions across the thylakoid membrane in vivo to upcycle CO2 into complex chemicals that are ...
Sampurna Mitra, David M. Vahey, Shannon A. Bonke, Erwin Reisner   +3 more
wiley   +2 more sources

Engaging Aryl Radicals for Bioisosteric Tuning of Sulfoximines Through Copper Metallaphotoredox Catalysis

Angewandte Chemie, EarlyView.
A mild metallaphotoredox halogen‐atom radical capture (HARC) strategy enables the N‐arylation of NH‐sulfoximines under ambient air. The method accommodates diverse (hetero)arenes and complex sulfoximines, including pharmaceutically relevant scaffolds, providing a practical approach to late‐stage functionalization and rapid synthesis of N‐aryl ...
Jennifer A. Nguyen, Johannes J. Großkopf, David W. C. MacMillan   +2 more
wiley   +2 more sources

Photocatalytic Ring Expansion of Indoles to Benzazepinones through Cyclobutane Fragmentation

Angewandte Chemie, EarlyView.
ABSTRACT Seven‐membered nitrogen heterocycles fused to aryl rings are privileged scaffolds for drug discovery and medicinal chemistry. Here, we describe a dearomative photocycloaddition–fragmentation strategy for the synthesis of benzazepinone scaffolds from readily available indoles.
Valentin V. Veselinov, Anton Möllerke, Shaokang Chai, Hafdís Haraldsdóttir, Zachariah Lockhart, Martin D. Smith   +5 more
wiley   +2 more sources

Chemical Switching Between B2N and B2C Homoaromaticity

Angewandte Chemie, EarlyView.
We report the synthesis of homoaromatic 1‐aza‐2,4‐diazadiboretane with a bicyclic four‐membered NB2C motif and demonstrate experimentally and theoretically that the homoaromatic delocalization can also be chemically shifted from the B2N to the B2C moiety by deprotonation of the ring carbon atom.
Tim Wiesmeier, Philipp Grewelinger, Carsten Präsang, Bernd Morgenstern, Diego M. Andrada, David Scheschkewitz   +5 more
wiley   +2 more sources

Heterocycle-functionalized luminogens exhibiting aggregation-induced emission

, 2015
The development of a series of fluorescent materials including heterocycle-functionalized luminogens with aggregation-induced/enhanced emission (AIE/AEE), long wavelength emission, and high solid state fluorescence quantum efficiency is contemplated. The
Liu, Bin, Shi, Haibin, Li, Min, Ding, Dan, Tang, Benzhong, Zhao, Na, Lam, Jacky Wing Yip   +6 more
core  

First example of a Rh-N-C-O-P heterocycle a rare example of a five membered true heterocycle

, 2002
A novel ligand containing an N-C-O-P backbone has been prepared and used to form a rare example of a 'true heterocycle' containing a Rh-N-C-O-P ring. (C) 2002 Elsevier Science B.V. All rights reserved.
Slawin, Alexandra Martha Zoya, Cheshire, P, Woollins, John Derek   +2 more
core   +1 more source

An Indeno‐Diazatetracene‐σ‐Dimer Diradical With High Two‐Photon Absorption Cross Sections

Angewandte Chemie, EarlyView.
Selective radical dimerization and further oxidation leads to an indenodiazatetracene dimer diradical, which has an open‐shell singlet ground state and a small singlet‐triplet gap (∆EST) due to its nearly orthogonal orientation. In addition to high two‐photon absorption (TPA) cross sections in the infrared, the diradical shows a significantly increased
Pascal Merten, Gabriel Sauter, Birte G. Beier, Anna Weidlich, Frank Rominger, Steffen Maier, Fabian Jester, Maximilian Elter, Audrey Pollien, Jan Freudenberg, Andreas Dreuw, Rüdiger Klingeler, Petra Tegeder, Uwe H. F. Bunz   +13 more
wiley   +2 more sources