Results 191 to 200 of about 27,695 (265)

Structural Modification of Sesquiterpene Lactones via Michael Addition: Improved Bioactivity and Pharmacokinetics. [PDF]

Int J Mol Sci
Ha MW, Kang J, Lee S, Paek SM.
europepmc   +1 more source

Emerging Strategies for <i>meta</i>-Heteroatom Functionalization of Pyridines. [PDF]

JACS Au
Francisco TN, Silva AMS, Albuquerque HMT.   +2 more
europepmc   +1 more source

Trinuclear Heptamethine Dyes for Shortwave Infrared In Vivo Imaging. [PDF]

Angew Chem Int Ed Engl
Garcia CA, Lin EY, Mobley EB, Louie A, Hartung KM, Araujo JA, Sletten EM.   +6 more
europepmc   +1 more source

Frame-Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design. [PDF]

Angew Chem Int Ed Engl
Bastick KAC, Griesbach CE, Huang BZ, Cordell MJ, Ou YD, Aspuru-Guzik A, Yudin AK.   +6 more
europepmc   +1 more source

Regioselective [3 + 2] cycloaddition reactions of the phosphorus and arsenic analogues of the thiocyanate anion. [PDF]

Chem Sci
Baltrun M, Hanneberg D, Hett F, Seidl M, Weigend F, Hohloch S.   +5 more
europepmc   +1 more source

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

C6-ROMP Enabled by Structure-Guided Monomer Design for Chemically Recyclable Polymers. [PDF]

Nat Commun
Choi K, Choi W, Chung M, Im B, Hong SH.
europepmc   +1 more source

High-Performance Photochromic Diarylethene with a Boron-Nitrogen Heterocyclic Ethene Bridge. [PDF]

Molecules
Zhang C, Dai Y, Chen Y, Dong S, Wang J.
europepmc   +1 more source

Novel Compounds as Plasma Kallikrein Inhibitors for Treating Hereditary Angioedema, Diabetic Macular Edema, and Diabetic Retinopathy. [PDF]

ACS Med Chem Lett
Sabnis RW.
europepmc   +1 more source

Fused 3D boron heterocycles <i>via</i> EnT catalysis: synthesis, modification and validation as beta-lactamase inhibitors. [PDF]

Chem Sci
Kortman HM, Fang H, Bastick KAC, Völkel C, Oberthür D, Seeberger PH, Perbandt M, Molloy JJ.   +7 more
europepmc   +1 more source