Chemical Methods for Peptide and Protein Backbone Cleavage
ChemistryEurope, EarlyView.Protein cleavage plays essential roles in biology and is powerful for protein manipulation and functionalization as well as in recombinant expression and purification. Here, the historical background and most recent examples of chemical methods for protein and peptide backbone cleavage are discussed (part of the figure was generated in BioRender).
Miguel Angel Alena‐Rodriguez +1 more
wiley +1 more source
Enantioselective Synthesis of Spirocyclic Nitrogen-Containing Heterocycles Catalyzed by an Iridium-Containing Cytochrome. [PDF]
J Am Chem SocXu J +7 more
europepmc +1 more source
Gold(I)‐Catalyzed Domino Cyclization for the Construction of Trispirocyclic Cyclohexanes
ChemistryEurope, EarlyView.We describe herein a series of intricate trispirocyclic architectures that have been synthesized from readily available substrates through an operationally simple one‐pot transformation under mild conditions. An unprecedented gold(I)‐catalyzed domino cyclization involving 2‐ethynylbenzyl alcohol derivatives and heterocyclic α,β‐unsaturated imines ...
Manon Genet +3 more
wiley +1 more source
Alumanyl silanides as multifunctional reagents for olefin cycloaddition, CO hydrosilylation, and reductive CO coupling. [PDF]
Chem SciLudwig M +4 more
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Intramolecular N···F Pnictogen Bond Mitigates the Explosive Behavior of Azido‐L‐Phenylalanines
ChemistryEurope, EarlyView.An intramolecular N···F pnictogen bond is the key for the chemical stabilization of the fluorinated azido‐L‐phenylalanines, mitigating the risk of explosion and thus facilitating the handling and storage of these materials. Organic azides are versatile intermediates but are plagued by intrinsic instability and potential explosiveness. Here, it is shown
Andrea Pizzi +5 more
wiley +1 more source
Asymmetric [3 + 2] Cycloaddition to Access 3-Pyrrolines and Their Switchable Transformations to Nine-Membered Cyclic Sulfamidates and 2H-Pyrroles. [PDF]
Adv Sci (Weinh)Choi SM, Park JU, Kim JH.
europepmc +1 more source
The Challenging P‐Alkylation of Aromatic Phosphorus Heterocycles and Follow‐Up Reactions
ChemistryEurope, EarlyView.P‐alkylation of λ3σ2‐phosphinines is hindered by weak nucleophilicity and scarce synthetic access, previously requiring multistep routes or extreme electrophiles. A direct ambient‐condition method is reported using 3,5‐bis(trimethylsilyl)‐phosphinine/B(C6F5)3 with esters or iso(thio)cyanates to generate stable 1‐R‐phosphininium salts.
Samantha Frank +6 more
wiley +1 more source
[3 + 2] Cycloaddition of thioformylium methylide with various arylidene-azolones in the synthesis of 7-thia-3-azaspiro[4.4]nonan-4-ones. [PDF]
Beilstein J Org ChemRudik DI +7 more
europepmc +1 more source
ChemistryEurope, EarlyView.The cis‐2,3‐bis(trifluoromethyl)cyclopropyl chemotype is introduced. The steric demand of this motif is intermediate between that of the heptafluoroisopropyl and prefluorotertbutyl groups; yet, it induces significantly less lipophilicity than these due to its facial polarity.
Daniel Gaviña +5 more
wiley +1 more source
Computational Study of Ignored Pericyclic Reactions: Rearrangements of 1,2-Bis(Diazo)Alkanes to 1,2,3,4-Tetrazines and Subsequent Fragmentations. [PDF]
Angew Chem Int Ed EnglReissig HU, Würthwein EU.
europepmc +1 more source