Results 191 to 200 of about 468,328 (285)
ChemMedChem, Volume 21, Issue 21, 12 November 2026.Can a single element help address the multifactorial nature of ALS? Boron‐containing compounds combine responsiveness to reactive oxygen species (ROS), neuroprotective activity, and favorable pharmacological properties, offering a distinctive framework for disease modification in a complex disease like ALS.
Nitesh Sanghai +5 more
wiley +1 more source
Regioselective Diversification of Aminopyrazoles via Ir‐Catalyzed C─H Borylation
Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.Aminopyrazoles, an important bioactive pharmacophore, are typically accessed inefficiently through de novo syntheses that yield isomeric mixtures of 3‐ and 5‐substituted derivatives. To address this challenge, we have elaborated readily available 3‐ and 5‐aminopyrazole fragments using Ir C─H borylation, regioselectively furnishing boronates for ...
Jay S. Wright +9 more
wiley +1 more source
Strain and Chirality: Catalytic Asymmetric Synthesis of Planar Chiral [2.2]Paracyclophanes
ChemistryEurope, Volume 4, Issue 11, November 2026.Catalytic asymmetric synthesis is transforming access to planar‐chiral [2.2]paracyclophanes. This Review highlights recent advances in catalytic desymmetrization and asymmetric functionalization, emphasizing how catalyst design and PCP geometry govern reactivity and stereocontrol.
Daniel Alonso +2 more
wiley +1 more source
Experimental methods in chemical engineering: Cyclic voltammetry—CV
The Canadian Journal of Chemical Engineering, Volume 104, Issue 11, Page 5776-5827, November 2026.Abstract Cyclic voltammetry (CV) is a foundational electroanalytical technique for investigating redox behaviour and evaluating material performance across fields such as molecular electrochemistry, electrocatalysis, sensing, and energy storage. Despite its widespread use, a gap remains between formal electrochemical theory and the practical data ...
Yasser Matos‐Peralta +4 more
wiley +1 more source
Use of Polycyclic Aromatic Compounds as Electrophotocatalysts in Organic Reactions
Chemistry–Methods, Volume 6, Issue 11, November 2026.Emerging from the convergence of photoredox catalysis and electrochemistry, electrophotocatalysis is a relatively new and promising synthetic approach in organic chemistry. In this review, the main advantages and the current challenges of this methodology are discussed, while most relevant and late applications of polycyclic aromatic hydrocarbons (PAHs)
Marco Manni +3 more
wiley +1 more source
Drug Development Research, Volume 87, Issue 7, November 2026.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disease, and cholinergic dysfunction is considered one of the fundamental pathological factors of this disease. Guided by the clinically used acetylcholinesterase (AChE) inhibitor donepezil, we explored trimetazidine dihydrochloride as an accessible starting scaffold to generate ...
Muhammed Oğuzhan Doğan +6 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 6, November 2026.Plant‐derived probiotics from fermented foods exert anti‐respiratory virus effects via immune regulation, antiviral metabolites, and gut–lung axis, highlighting their advantages, key technologies, and application prospects. ABSTRACT Respiratory viral infections represent a major global public health threat, causing widespread morbidity, mortality, and ...
Yinghao Xing +6 more
wiley +1 more source
ChemistryOpen, Volume 15, Issue 11, November 2026.A zinc single‐atom catalyst anchored on nitrogen‐doped mesoporous carbon (Zn@NMC) was synthesized via an evaporation‐induced self‐assembly method and applied in the one‐pot synthesis of 2,4(5)‐diarylimidazoles. The catalyst was fully characterized using FT‐IR, XRD, SEM, EDX, BET, and TGA analyses.
Maryam Shojaei‐Asl, Mohsen Moradian
wiley +1 more source
ChemistryOpen, Volume 15, Issue 11, November 2026.Density functional theory (DFT) reveals how proton transfer involving ethanol leads to a Dimroth rearrangement of an anthraquinone derivative. The calculated energy profile identifies key intermediate compounds and transition states, showing that solvent‐mediated hydrogen‐bonding networks promote cyclization, while ring opening and ring closure occur ...
Dmytro Melnyk +3 more
wiley +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source