Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles
European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu +2 more
wiley +1 more source
Beyond a solvent: HFIP as a game-changing medium in heterocyclic ring construction. [PDF]
Beilstein J Org ChemAlakonda LM, Varala R, Seema V, Alam MM.
europepmc +1 more source
Selective N‐Functionalization of Pyrazoles
European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek +2 more
wiley +1 more source
Direct Access to Chiral Piperidines by Enantioselective HAT‐Initiated C(sp3)─H Oxidation
Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.The direct desymmetrization of piperidines is achieved through manganese‐catalyzed enantioselective α‐C(sp3)─H oxidation with hydrogen peroxide, affording versatile chiral N,O‐acetals in good yields and with high enantio‐ and diastereoselectivity. These intermediates provide access to diverse functionalized piperidines with retention of chirality ...
Sethuraman Muthuramalingam +5 more
wiley +1 more source
Sustainable and efficient silver nano-catalysed C-N bond-forming approaches in organic synthesis. [PDF]
RSC AdvSai K A, T P AK.
europepmc +1 more source
Sustainable Access to N‐Heterocycles: One‐Pot Cascade Synthesis of Pyrroles From Bio‐Derived Furans
Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.Highly dispersed platinum (Pt) clusters on Brønsted acid‐rich HY zeolite enable a one‐pot cascade conversion of bio‐derived furans and nitroarenes into pyrroles. Highly dispersed Pt sites ensure selective nitro hydrogenation, while Pt nanoparticles promote undesired over‐hydrogenation.
Haifeng Qi +5 more
wiley +1 more source
S<sub>N</sub>Ar-Functionalization of Diaryliodonium Salts: Access to Densely Substituted Arenes. [PDF]
JACS AuKersting L +3 more
europepmc +1 more source
Recent advances in copper-catalyzed direct hydroamination of alkenes with (hetero)aromatic amines. [PDF]
Beilstein J Org ChemLee H, Lee Y.
europepmc +1 more source
Visible-light-mediated synthetic approaches towards thiazoles: needs, recent advances, and future perspectives. [PDF]
RSC AdvAnjali, Kumar V.
europepmc +1 more source
Nanocatalyst-enabled amide bond formation: advances, mechanistic insights, and future perspectives. [PDF]
RSC AdvBehera S, Patra BN.
europepmc +1 more source