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Convenient Dimethylamino Amination in Heterocycles and Aromatics with Dimethylformamide.
ChemInform, 2004A convenient dimethylamino amination of various heterocyclic and aromatic compounds having activated chloro group has been carried out in good yields using dimethyl formamide (DMF).
Anu Agarwal, Prem M. S. Chauhan
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The Biological Oxidation of Aromatic Heterocyclic Amines
Xenobiotica, 1971Abstract1. Heterocyclic aromatic amines occur in many drugs and foreign compounds, as well as products of intermediary metabolism.2. Heterocyclic aromatic amine oxides occur naturally in plants, fungi and other micro-organisms but are rare in mammalian systems.3. Very few xenobiotics have been reported to form heterocyclic aromatic amine oxides and the
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Analysis of heterocyclic aromatic amines (HAA)
Fresenius' Journal of Analytical Chemistry, 1998A new method was developed for the analysis of heterocyclic aromatic amines (HAA) using HPLC-ESI-MS/MS with selected reaction monitoring (SRM). Detection limits between 0.1 and 50 ng/mL were achieved.
E. Richling +3 more
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Prostaglandin hydroperoxidase-dependent activation of heterocyclic aromatic amines
Carcinogenesis, 1989Heterocyclic aromatic amines, derived from the pyrolysis of amino acids and proteins, are potent mutagens in the Ames Salmonella assay with rodent liver activation. Additionally, heterocyclic aromatic amines are multipotent carcinogens. We report evidence that these compounds are substrates for the hydroperoxidase activity of prostaglandin H synthase ...
T W, Petry +5 more
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Analysis of the cancerogenic heterocyclic aromatic amines in fried meat
Fresenius' Journal of Analytical Chemistry, 2000Heterocyclic aromatic amines (HAs) are potential cancerogens found in heated meat and fish. From the precursors creatin/ine amino acids and carbohydrates the HAs are formed in very complex reactions at high temperatures. The concentration in meat is very low and the analysis especially the clean-up is critical due to the complex meat matrix.
M, Murkovic, W, Pfannhauser
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Enzyme polymorphisms influencing the metabolism of heterocyclic aromatic amines
Journal of Chromatography B, 2004Heterocyclic aromatic amines are dietary carcinogens possibly involved in human carcinogenesis, DNA-adduct formation being an obligatory step in this multistage process. Heterocyclic amine binding to DNA largely depends on the balance between metabolic activation and detoxification pathways and DNA repair efficiency.
Luisa, Airoldi +3 more
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Biomonitoring of heterocyclic aromatic amine metabolites in human urine
Cancer Letters, 1999Human exposure to heterocyclic aromatic amines such as MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline) may be monitored by measuring the levels of the heterocyclic aromatic amine in urine. In order to investigate the contribution of N-oxidation to the metabolism of MeIQx in vivo, we developed a biomonitoring procedure for the analysis and ...
W G, Stillwell +4 more
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Formation and mitigation of heterocyclic aromatic amines in fried pork
Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 2013Heterocyclic aromatic amines (HAAs) are potent mutagens and carcinogens generated during the heat processing of meat. HAAs, which are abundant in processed meat products, include 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx), and 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine ...
Yan, Zhang +3 more
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Heterocyclic aromatic amine content of selected beef flavors
Mutation Research/Genetic Toxicology, 1994Previous work has shown that meat extracts contain potent mutagenic and/or carcinogenic heterocyclic aromatic amines (HAAs). Because meat extracts and some beef flavors are produced from similar precursors and processing steps, the beef flavors may also contain HAAs.
L S, Jackson +3 more
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On the aromaticity of heterocycles containing the amine nitrogen or the ether oxygen
Tetrahedron, 1972A new method of predicting aromaticity [B. A. Hess, Jr. and L. J. Schaad, J. Am. Chem. Soc. 93, 305 (1971)] is extended to conjugated heterocyclic systems containing the amine nitrogen or the ether oxygen. Coulomb and resonance integrals for these atoms were determined using experimental heats of atomization.
B.Andes Hess, L.J. Schaad, C.W. holyoke
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